Data

Load data

We need the metadata file with all sample information, An output directory for all plots and tables, the qPCR results, the DGE results, and all the rds objects that were produced by “./runDTU.sh”.

##  [1] "Intercept"          "sex_M_vs_F"         "age_years"         
##  [4] "rin"                "PMI_hours"          "Batch_2_vs_1"      
##  [7] "Batch_3_vs_1"       "Batch_4_vs_1"       "Profile_PD_vs_Cont"
## [10] "Oligo_Genes"        "Microglia_Genes"

Result object and dataframe

Generating one main dataframe for use of downstream analysis. * Using data from the stageR result list, which has all transcripts and genes that are significant after stageR OFWER correction, i.e. 2 stage testing first the genes and then the transcripts. StageR was applied with alpha==0.05.
* Using the result data frame of both DRIMSeq and DEXSeq which holds the p-values and adjusted p-values, as reported by the respective tool as well as the effect size (i.e. the coefficient of the condition variable). * Using the main data object of both tools, which holds the original counts and or proportions.

##    Case    Case Control    Case Control    Case Control    Case Control 
##       1       1       0       1       0       1       0       1       0 
##    Case Control    Case Control    Case Control    Case Control    Case 
##       1       0       1       0       1       0       1       0       1 
## Control    Case Control    Case    Case    Case    Case    Case    Case 
##       0       1       0       1       1       1       1       1       1 
## Control 
##       0 
## Levels: 0 1
## Control    Case Control    Case Control    Case Control    Case Control 
##       0       1       0       1       0       1       0       1       0 
##    Case Control    Case Control    Case Control    Case Control    Case 
##       1       0       1       0       1       0       1       0       1 
## Control Control    Case 
##       0       0       1 
## Levels: 0 1

Analysis

Filtering (Fig.3)

Both workflows, DRIMSeq and DEXSeq use a collection of transcripts that is created with and filtered by DRIMSeq.
DRIMSeq’s filter function is applied to the scaled transcript counts that result from tximport (scaledTPM).

This is an extract of the filter function description by DRIMSeq:

" Filtering parameters should be adjusted according to the sample size of the experiment data and the number of replicates per condition.
* min_samps_gene_expr defines the minimal number of samples where genes are required to be expressed at the minimal level of min_gene_expr in order to be included in the downstream analysis.
Ideally, we would like that genes were expressed at some minimal level in all samples because this would lead to better estimates of feature ratios. (We defined this parameter to be equal to the number of samples).
* Similarly, min_samps_feature_expr and min_samps_feature_prop defines the minimal number of samples where features are required to be expressed at the minimal levels of counts min_feature_expr or proportions min_feature_prop.
* In differential transcript/exon usage analysis, we suggest using min_samps_feature_expr and min_samps_feature_prop equal to the minimal number of replicates in any of the conditions. (defined as n.small in our case, representing the number of samples of the smaller group (condition).
* For example, in an assay with 3 versus 5 replicates, we would set
these parameters to 3, which allows a situation where a feature is expressed in one condition but
may not be expressed at all in another one, which is an example of differential transcript/exon usage "

## [1] "Filter parameters discovery cohort:"
##          n.small                n min_feature_expr min_feature_prop 
##             11.0             28.0             10.0              0.1 
##    min_gene_expr 
##             10.0
## [1] "Filter parameters replication cohort:"
##          n.small                n min_feature_expr min_feature_prop 
##             10.0             21.0             10.0              0.1 
##    min_gene_expr 
##             10.0

Here I generate two dataframes from the tool data objects to extract counts (after scaling with scaledTPM). We use the counts in CPM to calculate rowwise means and medians to see differences of expression distribution before and after filtering.

## # A tibble: 2 x 3
##   Filter `median(rowMeans)` `sd(rowMeans)`
##   <fct>               <dbl>          <dbl>
## 1 before              0.432          871. 
## 2 after               1.79            12.4

## png 
##   2

Diagnostic plots (Fig.S1)

Volcano and MA plots

# generate dataframe with expression counts for plotting 
# DRIMSeq
exprMixed_drim <-  DRIMSeq::counts(obj$Ds$Ds_drim$discovery) %>%
    dplyr::mutate(meanExpr = rowMeans(as.matrix(.[grep('\\.', names(.))]))) %>%
    dplyr::select(feature_id, meanExpr) %>% dplyr::rename(tx_id = feature_id)
# join the general discovery DRIMSeq dataframe that we generated at the start, 
# with the expression dataframe to have all data in one (pvalues and expression)
df_drimTxLevel <- left_join(df_disc$drim, exprMixed_drim, by = "tx_id") %>%
    dplyr::rename(rankOtherTool = rankDex) 
# get the gene-level p-values for DRIMSeq 
geneLevel_drim <- as.data.frame(DRIMSeq::results(obj$Ds$Ds_drim$discovery)) %>%
    dplyr::select(gene_id, pvalue) %>% dplyr::rename(qvalue = pvalue)
# group dataframe by gene_id and calculate how many transcripts each gene has,
# then only keep one (randomly chosen) transcript per gene, so we keep only the gene information 
df_drim <- df_drimTxLevel %>% dplyr::group_by(gene_id) %>%
    dplyr::mutate(ntx=n()) %>% dplyr::distinct(gene_id, .keep_all = TRUE)
# and join with the dataframe above
df_drim <- left_join(df_drim, geneLevel_drim, by = "gene_id") 
# DEXSeq
# extract count data from DEXSeq using their accesor function and modify the tx_id column (original column is a concat of featureID and groupID)
tx_id <- as.data.frame(stringr::str_split(rownames(DEXSeq::featureCounts(obj$Ds$Ds_dex$discovery)), ":", simplify = TRUE))[, 2] 
exprMixed_dex <-  as.data.frame(DEXSeq::featureCounts(obj$Ds$Ds_dex$discovery)) %>%
    dplyr::mutate(meanExpr = rowMeans(.)) %>%
    dplyr::select(meanExpr)  
exprMixed_dex$tx_id <- tx_id
# join the expression data with the general dataset we generated at the start
df_dexTxLevel <- left_join(df_disc$dex, exprMixed_dex, by="tx_id") %>%
    dplyr::rename(rankOtherTool= rankDrim)
#get the gene-level results 
geneLevel_dex <- DEXSeq::perGeneQValue(DEXSeq::DEXSeqResults(obj$Ds$Ds_dex$discovery, independentFiltering = FALSE))
geneLevel_dex <- data.frame(gene_id = names(geneLevel_dex), qvalue = geneLevel_dex)
#count number of transcripts per gene
df_dex <- df_dexTxLevel %>% dplyr::group_by(gene_id) %>% dplyr::mutate(ntx = n()) 
#keep only one (randomly chosen) transcript per gene, as we only need gene info for further plotting 
df_dex <- df_dex %>% dplyr::distinct(gene_id,.keep_all = TRUE)
#joing gene-level result with df above
df_dex <- dplyr::left_join(df_dex, geneLevel_dex, by = "gene_id") 

#bind rows of both dataframes together
dfGeneLevel <- gdata::combine(df_drim, df_dex, names = c("DRIMSeq","DEXSeq")) %>%
    dplyr::rename(tool = source)
dfTxLevel <- gdata::combine(df_drimTxLevel, df_dexTxLevel, names = c("DRIMSeq","DEXSeq")) %>%
    dplyr::rename(tool = source)



plotVolcano <- function(df,alpha=0.05,title=""){

df$sig<-sapply(seq(1,nrow(df)),function(i)(ifelse(df[i,"nom_pval"]<0.05,"TRUE","FALSE")))
# the following lines mark the extreme DEXSeq p-value outliers such that they can be seen in the plot
df %<>% dplyr::mutate(outlier=ifelse(-log10(nom_pval)>10,TRUE,FALSE),nom_pval=ifelse(-log10(nom_pval)>10,10^-11,nom_pval))

ggplot(df) +
    geom_point(aes(x=l2fc,y=-log10(nom_pval),col=as.factor(sig),shape=outlier),alpha=0.3,show.legend=F) +
    geom_hline(yintercept=0)  +
    scale_color_manual(labels=c("TRUE"="p-value < 0.05","FALSE" = "not signif."),values=c("TRUE"="red","FALSE"="grey")) +
    labs(y="-log10(p-value)",x="effect size",col="Significance",tag=title) +
    facet_wrap(~tool)+#,scales="free_y") +
    #coord_fixed() +
    geom_vline(xintercept=-0.1,col="grey39") +
    geom_vline(xintercept=.1,col="grey39") +
    geom_hline(yintercept=-log10(alpha),col="darkblue",lty="dotted") +
        theme_bw() +
theme(plot.title = element_text(hjust = 0.5)) +
theme(strip.background=element_rect(fill="black")) + 
theme(strip.text= element_text(color="white",face="bold"))  

}


my_plotMA <- function(df,alpha=0.05,title=""){

df$sig<-sapply(seq(1,nrow(df)),function(i)(ifelse(df[i,"nom_pval"]<0.05,"TRUE","FALSE")))
df %<>% dplyr::mutate(outlier=ifelse(abs(l2fc)>3,TRUE,FALSE),l2fc=ifelse(abs(l2fc)>3,3.2,l2fc))
ggplot(df, aes(x=log10(meanExpr),y=l2fc,col=as.factor(sig))) +
    geom_point(alpha=0.3,aes(shape=outlier)) +
    facet_wrap(~tool) + 
    scale_color_manual(labels=c("TRUE"="p-value < 0.05","FALSE" = "not signif."),values=c("TRUE"="red","FALSE"="grey")) +
    labs(x="log10(mean expression)",y="Effect size",col="Significance",tag=title) +
        theme_bw() +
theme(plot.title = element_text(hjust = 0.5)) +
theme(strip.background=element_rect(fill="black")) +
theme(strip.text= element_text(color="white",face="bold"))  +
theme(legend.position="bottom",plot.tag = element_text(margin = margin(t=0))) +
theme(plot.margin=unit(c(0,0,0,0),"mm"))
    
}

plot_pvalDist<-function(df,tag) {
df %>% dplyr::mutate(ntxLabel=paste0(ntx," transcripts/gene")) %>%
ggplot(.,aes(x=qvalue,y=..density..)) +
geom_histogram(aes(fill=tool),col="black") +
geom_density() +
facet_grid(rows=vars(ntxLabel),cols=vars(tool),scales="free") +
scale_fill_manual(values=c("DEXSeq"=colorFriendly[["blue"]],"DRIMSeq"=colorFriendly[["orange"]]))+
theme_bw() +
theme(plot.title = element_text(hjust = 0.5)) +
theme(strip.background=element_rect(fill="black")) +
theme(strip.text= element_text(color="white",face="bold"))  +
labs(tag=tag,fill="Tool",x="gene-level p-value",y="density") 
}

p1 <- plotVolcano(dfTxLevel,title="a")
p2 <- my_plotMA(dfTxLevel,title="b")    
p3 <- plot_pvalDist(dfGeneLevel,tag="c")

(p1/p2 + plot_layout(heights=c(1,2))) | p3 

## png 
##   2

Tool agreement (Fig.4)

Comparing effect size of DRIMSeq and DEXseq.
Effect size refers to the coefficient of the model of the respective tool, which was assigned to the variable “condition”, i.e. CT vs PD.
For the effect size of DRIMSeq we applied a transformation: log2(exp(effectSize)).

## 
##  Pearson's product-moment correlation
## 
## data:  events$l2fc.x and events$l2fc.y
## t = 151.12, df = 812, p-value < 2.2e-16
## alternative hypothesis: true correlation is not equal to 0
## 95 percent confidence interval:
##  0.9801534 0.9848935
## sample estimates:
##       cor 
## 0.9826835
## [1] 97.94118
## [1] 97.20588

## png 
##   2

For the replication cohort(Fig. S2):

## png 
##   2

Replication cohort

## [1] "Number of transcripts in both cohorts"
## [1] 29807

Agreement on effect size across cohorts (Fig.6)

#plot correlation
cor <- T
# create replication cohort df's which contain all transcripts that are in the final discovery cohort list created at the beginning
final_repl_dex <- df_repl$dex %>% dplyr::filter(tx_id %in% final_disc_dex$tx_id) %>% dplyr::select(tx_id,gene_id,l2fc,nom_pval)
final_repl_drim <- df_repl$drim %>% dplyr::filter(tx_id %in% final_disc_drim$tx_id) %>% dplyr::select(tx_id ,gene_id,l2fc,nom_pval)
# join cohort dataframes for each tool
# DEXSeq
dfDex <- na.omit(left_join(final_disc_dex,final_repl_dex, by = "tx_id", suffix = c("_disc","_repl")))
# helper coloumn for plottig, whether or not transcript is nominally significant in repl. cohort according to DEXSeq
dfDex$sigRepl <-  sapply(dfDex$nom_pval_repl, function(i)(ifelse(i < 0.05, 1, 0)))
dfDex$label <- sapply(dfDex$gene_name, function(g)(ifelse(g %in% c("ZNF189"), as.character(g), "")))
# Do the same for DRIMSeq
dfDrim <- na.omit(left_join(final_disc_drim, final_repl_drim, by = "tx_id", suffix = c("_disc","_repl")))
dfDrim$sigRepl <-  sapply(dfDrim$nom_pval_repl, function(i)(ifelse(i < 0.05, 1, 0)))
dfDrim$label <- sapply(dfDrim$gene_name, function(g)(ifelse(g %in% "ZNF189", as.character(g), "")))
#only one transcript of the lab genes is significant after stageR,
#thats why we see only one point for each of the two genes in the plot
agreementPlot <- function(df,tag="",legend="none") {
ggplot(data=df,aes(x=l2fc_repl,y=l2fc_disc)) +
geom_point(aes(col=as.factor(sigRepl)),alpha=.3) +
stat_density2d(col="black",size=0.3) +
geom_abline(intercept = 0, slope = 1,lty="dashed",) +   
labs(title="",tag=tag,x="effect size replication cohort",y="effect size discovery cohort",col="Nominal p-value (replication cohort)") +
    scale_color_manual(values=c("1"="red","0"="black"),labels=c("1"="<0.05","0"=">0.05")) +
    facet_wrap(~Tool) + #,scales="free") +
scale_fill_manual(values=c("1"="red","0"="grey")) + 
    geom_hline(aes(yintercept=0),col="grey") +
     geom_vline(aes(xintercept=0),col="grey") +
     scale_x_continuous(limits=c(-max(c(abs(df$l2fc_repl),abs(df$l2fc_disc))),max(c(abs(df$l2fc_repl),abs(df$l2fc_disc))))) +
     scale_y_continuous(limits=c(-max(c(abs(df$l2fc_repl),abs(df$l2fc_disc))),max(c(abs(df$l2fc_repl),abs(df$l2fc_disc)))) )+
     coord_fixed() +
#    geom_label_repel(aes(label=label)) +
        theme_bw() +
theme(plot.title = element_text(hjust = 0.5)) +
theme(panel.spacing = unit(1, "lines")) +
theme(strip.background=element_rect(fill="black"))+
theme(strip.text= element_text(color="white",face="bold")) +
 guides(fill = FALSE, size = FALSE) +
theme(legend.position = legend)
}
df <- dfDex %>% dplyr::bind_rows("DEXSeq" = ., "DRIMSeq" = dfDrim, .id = "Tool")          
nrow(dfDrim)
## [1] 481
## [1] 0.3573096
## 
##  Pearson's product-moment correlation
## 
## data:  sign(dfDrim$l2fc_repl) and sign(dfDrim$l2fc_disc)
## t = 6.4678, df = 479, p-value = 2.457e-10
## alternative hypothesis: true correlation is not equal to 0
## 95 percent confidence interval:
##  0.1990432 0.3636012
## sample estimates:
##      cor 
## 0.283407
## [1] "percent agreement dex"
## [1] "62.83"
## [1] "percent agreement drim"
## [1] "64.24"
#Basically this is the same as above just that this time we do use all transcripts of discovery not only the ones which survived stageR correction
#This is only done for DRIMSeq this time
# define ids which are in both cohorts
ids <- Reduce(intersect,list(df_repl$drim$tx_id,df_disc$drim$tx_id))
# merge ids with replication df
df <- left_join(data.frame(tx_id = ids), df_repl$drim, by = "tx_id", suffix = c("","replication"))
# add discovery df
df <- left_join(df, df_disc$drim, by = "tx_id", suffix = c("_repl","_disc"))
#helper columns for plotting. 
#disc repl +(disc sig)(repl sig)(&&)  (||)
#   1  -1  0    1   1   1   1   
#  -1   2  1    0   0   0   0   
#   1   2  3    1   0   0   1   
#  -1  -1  2    0   1   0   1
#TODO: replace with dplyr instead of using sapply
df$sigDisc <- sapply(df$nom_pval_disc, function(i)(ifelse(i < 0.05, 1, -1)))
df$sigRepl <-  sapply(df$nom_pval_repl,function(i)(ifelse(i < 0.05, -1, 2)))
df$sigCol <- as.factor(sapply(seq(1, nrow(df)), function(i)(df[i, "sigDisc"] + df[i, "sigRepl"])))
# for plot legend
df$sigColLabel <- plyr::revalue(df$sigCol, c("0" = "Sig. in both cohorts", "1" = "Not sig. in either cohort", "3" = "Sig. in the discovery cohort only", "-2" = "Sig. in the replication cohort only"))
#replace stageR assigned NA value with 1s 
df$tx_pvalueStageR_repl <- sapply(df$tx_pvalueStageR_repl, function(i)(ifelse(is.na(i), 1, i)))
df$tx_pvalueStageR_disc <- sapply(df$tx_pvalueStageR_disc, function(i)(ifelse(is.na(i), 1, i)))
#helper col tags transcripts which have the same sign of l2fc (or effect size)
df$agreelfc <- as.factor(sapply(seq(1,nrow(df)),function(i) {
    ifelse(sign(df[i, "l2fc_repl"]) == sign(df[i,"l2fc_disc"]),1,0)
    }))
print("percentage of tx agreeing on direction disc. cohort not repl. cohort")
## [1] "percentage of tx agreeing on direction disc. cohort not repl. cohort"
## [1] "59.3"
## [1] "percentage of tx agreeing on direction disc. cohort and repl. cohort"
## [1] "62.37"
## [1] "percentage of tx agreeing on direction repl. cohort not disc. cohort"
## [1] "52.91"
## png 
##   2

Agreement on direction of effect size (run previous chunk to create df used here)

## [1] 25002
##         1 
## 0.5354372
## [1] 29807
## 
##  Pearson's product-moment correlation
## 
## data:  sign(nonSig$l2fc_disc) and sign(nonSig$l2fc_repl)
## t = 11.221, df = 25000, p-value < 2.2e-16
## alternative hypothesis: true correlation is not equal to 0
## 95 percent confidence interval:
##  0.05844659 0.08311340
## sample estimates:
##        cor 
## 0.07079081
## [1] 3776
## 
##  Pearson's product-moment correlation
## 
## data:  sign(sig$l2fc_disc) and sign(sig$l2fc_repl)
## t = 11.946, df = 3774, p-value < 2.2e-16
## alternative hypothesis: true correlation is not equal to 0
## 95 percent confidence interval:
##  0.1599510 0.2214241
## sample estimates:
##       cor 
## 0.1908747
## [1] 186
## 
##  Pearson's product-moment correlation
## 
## data:  sign(sig$l2fc_disc) and sign(sig$l2fc_repl)
## t = 3.4838, df = 184, p-value = 0.0006178
## alternative hypothesis: true correlation is not equal to 0
## 95 percent confidence interval:
##  0.1087676 0.3790664
## sample estimates:
##       cor 
## 0.2487541
## [1] 843
## 
##  Pearson's product-moment correlation
## 
## data:  sign(sig$l2fc_disc) and sign(sig$l2fc_repl)
## t = 1.685, df = 841, p-value = 0.09235
## alternative hypothesis: true correlation is not equal to 0
## 95 percent confidence interval:
##  -0.009553114  0.125039125
## sample estimates:
##        cor 
## 0.05800659

Numbers for paper result section

Number of genes with a significant pvalue after stageR

## [1] "DEXSeq"
## [1] 254
## [1] "DRIMSeq"
## [1] 495
## [1] "all genes"
## [1] 584
## [1] 814
## [1] "tool int"
## [1] 165

How many transcrips of which transcript biotype were significant

## [1] "DRIMSeq"
## 
##                          antisense                            lincRNA 
##                                 15                                 22 
##            nonsense_mediated_decay               processed_pseudogene 
##                                 18                                  4 
##               processed_transcript                     protein_coding 
##                                 94                                455 
##                    retained_intron transcribed_unprocessed_pseudogene 
##                                 70                                  2
## [1] "DEXSeq"
## 
##               antisense                 lincRNA nonsense_mediated_decay 
##                       5                       5                      14 
##    processed_transcript          protein_coding         retained_intron 
##                      58                     208                      50

How many transcrips per gene

## [1] "DRIMSeq"
## 
##   1   2   3 
## 312 181   2
## [1] "DEXSeq"
## 
##   1   2   3 
## 173  76   5

Number of missing genes in replication due to low expression

## [1] "DEXSeq"
## l2fc.y 
##     83
##           tx_id       gene_name         gene_id          l2fc.x 
##             254             254             254             254 
## tx_pvalueStageR      nom_pval.x      tx_biotype      nom_pval.y 
##             254             254             254             171 
##          l2fc.y 
##             171
## [1] "DRIMSeq"
## l2fc.y 
##    130
##           tx_id         gene_id       gene_name          l2fc.x 
##             495             495             495             495 
## tx_pvalueStageR      nom_pval.x      tx_biotype      nom_pval.y 
##             495             495             495             365 
##          l2fc.y 
##             365

Format function for latex:

Latex tables

##             tx_id         gene_id gene_name l2fc_disc tx_pvalueStageR
## 1 ENST00000334029 ENSG00000100033     PRODH -1.479819        0.003288
## 2 ENST00000264381 ENSG00000114200      BCHE -1.814029        0.000000
## 3 ENST00000540653 ENSG00000114200      BCHE  1.814029        0.000000
##   nom_pval_disc     tx_biotype nom_pval_replication l2fc_replication
## 1  4.586449e-05 protein_coding           0.01234035        -1.392379
## 2  1.976966e-04 protein_coding           0.03510185        -1.063644
## 3  1.976966e-04 protein_coding           0.03510185         1.063644
##    baseMean log2FoldChange     lfcSE      stat       pvalue       padj
## 1 1761.1068     -1.1671971 0.2646551 -4.410258 1.032475e-05 0.01093284
## 2  186.5362     -0.9567699 0.2313975 -4.134746 3.553482e-05 0.01621397
## 3  186.5362     -0.9567699 0.2313975 -4.134746 3.553482e-05 0.01621397
##   length(unique(gene_id))
## 1                      17

These plots are not included in the paper but nice to have for a quick look.

#DRIMSeq
#the same as above
df_drim <- na.omit(left_join(final_disc_drim,obj$main_df$replication$drim[,c("tx_id", "nom_pval","l2fc")],by="tx_id",suffix=c("_disc","_repl"))) %>%
    dplyr::filter(sign(l2fc_disc) == sign(l2fc_repl), nom_pval_repl < 0.05) 
#
#DEXSeq
#exclue all transcripts which are not present in replication (NA's)
df_dex <- na.omit(left_join(final_disc_dex, obj$main_df$replication$dex[, c("tx_id", "nom_pval", "l2fc")], by = "tx_id", suffix = c("_disc","_repl"))) %>% 
    dplyr::filter(sign(l2fc_disc) == sign(l2fc_repl), nom_pval_repl < 0.05) 
#plot all replicated DTU genes of DRIMSeq
genes_to_plot <- DTU::get_gene_info(unique(df_drim$tx_id,df_dex), tx = T)
# Generate count plots and count dfs for both cohorts for those transcripts
# This is an annoying problem: Within DRIMSeq (e.g. when calling counts), sample_ids get changed
# Probably somewhere in as.data.frame where check.names==T 
# hyphens become dots (Ctr-1 -> Ctr.1)
# dirty quick fix (not necessary for DEXSeq)
new_obj <- obj
new_obj$info <- lapply (obj$info, function (i) {
        i %<>% dplyr::mutate(sample_id = gsub("-",".",sample_id))
        })
new_obj$dge <- lapply(new_obj$dge, function (o) {
        snames <- gsub("-",".",colnames(o))
        SummarizedExperiment::colData(o) %<>% as.data.frame() %>% 
            dplyr::mutate(sample_id = snames, sample_id1 = snames,
                      sample_id2 = snames) %>%
                DataFrame()
        colnames(o) <- snames
        return(o)
        })
plots <- DTU::plot_genes_cohort(genes_toplot = genes_to_plot ,
                 tool = "drim",
                 only_nom_sig = F,
                 conditions = c("CT","PD"),
                 out = plotOutDir,
                 obj = new_obj,
                 cohort = "discovery",
                 selected_samples = NULL,
                 want_jitter = F)
## [1] "extracting counts from the provided count object assuming it is a drim object"

AS studied in PD genes

SNCA,PARK2,PARK7,GBA,PINK1,SRRM2,GBA,FBXO7,LRRK2

##             tx_id gene_pvalueStageR tx_pvalueStageR  nom_pval toolAdjPval
## 1 ENST00000506244                NA              NA 0.0553810   0.3879063
## 2 ENST00000394991                NA              NA 0.2001971   0.6406055
## 3 ENST00000394989                NA              NA 1.0000000   1.0000000
## 4 ENST00000336904                NA              NA 1.0000000   1.0000000
##           gene_id gene_name     tx_biotype        l2fc rankDex
## 1 ENSG00000145335      SNCA protein_coding -0.48521625    7988
## 2 ENSG00000145335      SNCA protein_coding  0.39047771    7870
## 3 ENSG00000145335      SNCA protein_coding  0.03641492   36731
## 4 ENSG00000145335      SNCA protein_coding  0.07639267   35458
##             tx_id gene_pvalueStageR tx_pvalueStageR   nom_pval toolAdjPval
## 1 ENST00000394991                NA              NA 0.07418454   0.3819514
## 2 ENST00000506244                NA              NA 0.07617850   0.3860695
## 3 ENST00000336904                NA              NA 0.82509968   0.9428913
## 4 ENST00000394989                NA              NA 0.86948859   0.9591693
##           gene_id gene_name     tx_biotype        l2fc rankDrim
## 1 ENSG00000145335      SNCA protein_coding  0.36728038    12663
## 2 ENSG00000145335      SNCA protein_coding -0.57280076     5785
## 3 ENSG00000145335      SNCA protein_coding  0.08534661    39040
## 4 ENSG00000145335      SNCA protein_coding  0.06685536    39039
##  [1] tx_id             gene_pvalueStageR tx_pvalueStageR  
##  [4] nom_pval          toolAdjPval       gene_id          
##  [7] gene_name         tx_biotype        l2fc             
## [10] rankDex          
## <0 rows> (or 0-length row.names)
##  [1] tx_id             gene_pvalueStageR tx_pvalueStageR  
##  [4] nom_pval          toolAdjPval       gene_id          
##  [7] gene_name         tx_biotype        l2fc             
## [10] rankDrim         
## <0 rows> (or 0-length row.names)
##             tx_id gene_pvalueStageR tx_pvalueStageR  nom_pval toolAdjPval
## 1 ENST00000366898                NA              NA 0.7949749    0.947643
## 2 ENST00000366892                NA              NA 0.7949749    0.947643
##           gene_id gene_name     tx_biotype        l2fc rankDex
## 1 ENSG00000185345     PARK2 protein_coding  0.08697873   37508
## 2 ENSG00000185345     PARK2 protein_coding -0.08697873   37563
##             tx_id gene_pvalueStageR tx_pvalueStageR  nom_pval toolAdjPval
## 1 ENST00000366898                NA              NA 0.8976597   0.9697126
## 2 ENST00000366892                NA              NA 0.8995228   0.9703191
##           gene_id gene_name     tx_biotype        l2fc rankDrim
## 1 ENSG00000185345     PARK2 protein_coding  0.04684074    33986
## 2 ENSG00000185345     PARK2 protein_coding -0.04726718    33987

DGE and DTU intersection (Fig. 1)

DGE <- subset(obj$dge_results$discovery, padj < 0.05)
df <- final_disc_dexdrim
df %<>% dplyr::group_by(Tool) %>%
    dplyr::count(tx_biotype) %>%
    mutate(sum = sum(n), frac = 100 * (n / sum(n)))%>%
    mutate(tx_biotype = ifelse(tx_biotype == "transcribed_unprocessed_pseudogene", paste0("transcribed_processed","\n","pseudogene"),tx_biotype))

resultPlotBiotype <- ggplot(data = df, aes(x = tx_biotype, fill = Tool)) +
    geom_bar(aes(y = frac), stat = "identity") +
    scale_fill_manual(values = c("DEXSeq" = colorFriendly[["blue"]], 
                 "DRIMSeq" = colorFriendly[["orange"]])) +
    facet_wrap(~Tool, scales = "free") +
    theme_bw() +
    coord_flip() +
    #theme(axis.text.x = element_text(angle = 45)) +
    labs(x = "Transcript biotype (Ensembl v75)", y = "Frequency (%)", tag = "b", fill = "") +
       theme(panel.spacing = unit(1, "lines")) +
    theme(strip.background = element_rect(fill = "black"))+
    theme(legend.position = "none")+
    theme(strip.text = element_text(color = "white", face = "bold")) 

drim <- unique(final_disc_drim$gene_id)
dex <- unique(final_disc_dex$gene_id)

n12=length(Reduce(intersect,list(dex,drim)))
n13=length(Reduce(intersect,list(dex,DGE$gene_id)))
n23=length(Reduce(intersect,list(drim,DGE$gene_id)))
n123=length(Reduce(intersect,list(drim,dex,DGE$gene_id)))

venn<-draw.triple.venn(ind=F, cat.fontfamily = "sans", fontfamilyi = "sans", area1 = length(dex), area2 = length(drim), area3 = length(DGE$gene_id), n12 = n12, n13 = n13, n23 = n23, n123 = n123, category = c("DEXSeq", "DRIMSeq", "DGE"), fill = c(colorFriendly["blue"], colorFriendly["orange"], colorFriendly["green"]), ext.text = TRUE, label.col = "white", alpha = .7,cat.dist=c(.1,.1,.1))
lay<-rbind(c(1,NA,NA,NA),
       c(NA,2,2,NA), 
       c(NA,2,2,NA),
       c(3,3,3,3),
       c(3,3,3,3),
       c(3,3,3,3),
       c(3,3,3,3))

grid.arrange(textGrob("a"),gTree(children=venn),resultPlotBiotype,layout_matrix=lay)

## png 
##   2

Correlation of effect size: DTU, DGE

dge <- dge_results$discovery %>% dplyr::filter(gene_id %in% c(final_disc_drim$gene_id, final_disc_dex$gene_id))
# Join dge with dtu results, i.e. select max(abs(l2fc)) in a gene group
drim <- final_disc_drim %>% dplyr::filter(tx_biotype == "protein_coding") 
dex <- final_disc_dex %>%  dplyr::filter(tx_biotype == "protein_coding") 
df <- dplyr::bind_rows("DRIMSeq" = drim, "DEXSeq" = dex, .id = "Tool")
dge <- dplyr::left_join(df, dge, by = "gene_id", suffix = c("dge", "dtu")) %>%
       dplyr::group_by(Tool, gene_id) %>%
       dplyr::add_tally() %>%
       dplyr::mutate(sig = ifelse(padj < 0.05, 1, 0))
# For the plot of genes with two DTU events
twoTx <- ggplot(subset(dge, n == 2), aes(x = log2FoldChange, y = l2fc, group = gene_id)) +
    geom_point(aes(col = padj)) +
    geom_line(lwd = 0.5, col = "grey", alpha = .5) +
    geom_rug(col=rgb(.5, 0, 0, alpha = .2)) +
    facet_wrap(~ Tool) +
    labs(x = "Effect size DGE", col = "Adj. p-value DGE", y = "Effect size DTU", tag = "a") +
    theme_bw() +
    theme(strip.background = element_rect(fill = "black"))+
    theme(strip.text = element_text(color = "white", face = "bold")) + 
    theme(legend.position = "bottom") +
    guides(col = "none")
# Plot with genes with one DTU event
OneTx <- ggplot(subset(dge, n == 1), aes(x = log2FoldChange, y = l2fc)) +
     geom_point(aes(col = padj)) +  
         geom_smooth(lwd = 0.5, col = "black") +
         stat_cor(method = "pearson") +
         geom_rug(col = rgb(.5, 0, 0, alpha = .2)) +
         facet_wrap(~ Tool) +
         theme_bw() +
         theme(strip.background = element_rect(fill = "black"))+
         theme(strip.text = element_text(color = "white", face = "bold")) + 
         theme(legend.position = "bottom") +
         labs(x = "Effect size DGE", y = "Effect size DTU", col = "Adj. p-value DGE", tag = "b")
grid.arrange(twoTx,OneTx)       

## png 
##   2

Gene set enrichment analysis

With STRINGdb and a background comprised of all genes which showed sufficient expression to survive filtering.
(Discovery cohort and DRIMSeq)

## Warning:  we couldn't map to STRING 5% of your identifiers
## Warning:  we couldn't map to STRING 13% of your identifiers
## IGRAPH 9bdd806 UN-- 11026 1713941 -- 
## + attr: name (v/c), neighborhood (e/n), neighborhood_transferred
## | (e/n), fusion (e/n), cooccurence (e/n), homology (e/n),
## | coexpression (e/n), coexpression_transferred (e/n), experiments
## | (e/n), experiments_transferred (e/n), database (e/n),
## | database_transferred (e/n), textmining (e/n),
## | textmining_transferred (e/n), combined_score (e/n)
## + edges from 9bdd806 (vertex names):
## [1] 9606.ENSP00000003100--9606.ENSP00000008527
## [2] 9606.ENSP00000003100--9606.ENSP00000054666
## [3] 9606.ENSP00000003100--9606.ENSP00000200652
## + ... omitted several edges
term_id proteins hits pvalue pvalue_fdr term_description
GO:0050793 1112 33 0.0000000 0.0000146 regulation of developmental process
GO:0032879 1252 35 0.0000000 0.0000146 regulation of localization
GO:0045595 769 26 0.0000000 0.0000245 regulation of cell differentiation
GO:0051094 594 22 0.0000001 0.0000500 positive regulation of developmental process
GO:2000026 820 26 0.0000001 0.0000527 regulation of multicellular organismal development
GO:0051049 944 28 0.0000001 0.0000531 regulation of transport
GO:0035556 1071 30 0.0000001 0.0000531 intracellular signal transduction
GO:0051239 1216 32 0.0000002 0.0000689 regulation of multicellular organismal process
GO:0051128 1278 32 0.0000005 0.0001847 regulation of cellular component organization
GO:0032535 169 11 0.0000007 0.0001889 regulation of cellular component size
GO:0002376 981 27 0.0000008 0.0001889 immune system process
GO:0007399 1172 30 0.0000008 0.0001889 nervous system development
GO:0044711 805 24 0.0000009 0.0001889 single-organism biosynthetic process
GO:0033554 1048 28 0.0000009 0.0001889 cellular response to stress
GO:0023051 1469 34 0.0000014 0.0002620 regulation of signaling
GO:0045428 21 5 0.0000014 0.0002620 regulation of nitric oxide biosynthetic process
GO:0044712 499 18 0.0000016 0.0002869 single-organism catabolic process
GO:0010033 1304 31 0.0000025 0.0004221 response to organic substance
GO:0007049 861 24 0.0000028 0.0004418 cell cycle
GO:0006793 1183 29 0.0000030 0.0004471 phosphorus metabolic process
GO:0090066 196 11 0.0000031 0.0004471 regulation of anatomical structure size
GO:0022402 691 21 0.0000032 0.0004471 cell cycle process
GO:0006796 1158 28 0.0000059 0.0007767 phosphate-containing compound metabolic process
GO:0045597 443 16 0.0000061 0.0007767 positive regulation of cell differentiation
GO:0009966 1299 30 0.0000066 0.0008001 regulation of signal transduction
GO:0000278 558 18 0.0000076 0.0008852 mitotic cell cycle
GO:0009719 734 21 0.0000082 0.0009205 response to endogenous stimulus
GO:0010605 1250 29 0.0000088 0.0009439 negative regulation of macromolecule metabolic process
GO:1903426 30 5 0.0000090 0.0009439 regulation of reactive oxygen species biosynthetic process
GO:0050767 358 14 0.0000098 0.0009913 regulation of neurogenesis
GO:0051960 410 15 0.0000104 0.0009987 regulation of nervous system development
GO:0033036 1262 29 0.0000105 0.0009987 macromolecule localization
GO:0071702 1130 27 0.0000110 0.0010116 organic substance transport
GO:0006260 147 9 0.0000125 0.0010854 DNA replication
GO:0051240 695 20 0.0000125 0.0010854 positive regulation of multicellular organismal process
GO:0050790 1280 29 0.0000137 0.0011585 regulation of catalytic activity
GO:0042592 642 19 0.0000141 0.0011615 homeostatic process
GO:0048699 766 21 0.0000155 0.0012418 generation of neurons
GO:0048011 195 10 0.0000194 0.0015109 neurotrophin TRK receptor signaling pathway
GO:0038179 198 10 0.0000221 0.0016802 neurotrophin signaling pathway
GO:0051051 243 11 0.0000238 0.0017255 negative regulation of transport
GO:0009892 1389 30 0.0000238 0.0017255 negative regulation of metabolic process
GO:0060284 444 15 0.0000263 0.0018199 regulation of cell development
GO:0048598 293 12 0.0000273 0.0018199 embryonic morphogenesis
GO:0006261 62 6 0.0000282 0.0018199 DNA-dependent DNA replication
GO:0033260 19 4 0.0000283 0.0018199 nuclear DNA replication
GO:0044786 19 4 0.0000283 0.0018199 cell cycle DNA replication
GO:0045892 617 18 0.0000290 0.0018199 negative regulation of transcription, DNA-templated
GO:0051130 677 19 0.0000293 0.0018199 positive regulation of cellular component organization
GO:0045664 297 12 0.0000311 0.0018663 regulation of neuron differentiation
GO:0010604 1481 31 0.0000313 0.0018663 positive regulation of macromolecule metabolic process
GO:0010821 207 10 0.0000323 0.0018909 regulation of mitochondrion organization
GO:0051704 1069 25 0.0000341 0.0019599 multi-organism process
GO:0010629 810 21 0.0000352 0.0019850 negative regulation of gene expression
GO:0048513 1351 29 0.0000370 0.0020485 organ development
GO:0043279 66 6 0.0000404 0.0021573 response to alkaloid
GO:0080135 461 15 0.0000404 0.0021573 regulation of cellular response to stress
GO:0016310 697 19 0.0000434 0.0022783 phosphorylation
GO:0051246 1373 29 0.0000495 0.0025538 regulation of protein metabolic process
GO:2000113 709 19 0.0000546 0.0027669 negative regulation of cellular macromolecule biosynthetic process
GO:0060249 138 8 0.0000564 0.0028141 anatomical structure homeostasis
GO:0010822 182 9 0.0000673 0.0032997 positive regulation of mitochondrion organization
GO:0033043 660 18 0.0000691 0.0033144 regulation of organelle organization
GO:0051000 9 3 0.0000697 0.0033144 positive regulation of nitric-oxide synthase activity
GO:0071363 376 13 0.0000725 0.0033746 cellular response to growth factor stimulus
GO:0060341 663 18 0.0000732 0.0033746 regulation of cellular localization
GO:0080134 798 20 0.0000868 0.0039075 regulation of response to stress
GO:0007166 1134 25 0.0000883 0.0039075 cell surface receptor signaling pathway
GO:1902589 1276 27 0.0000899 0.0039075 single-organism organelle organization
GO:0022603 495 15 0.0000899 0.0039075 regulation of anatomical structure morphogenesis
GO:0070848 386 13 0.0000944 0.0040452 response to growth factor
GO:0038095 111 7 0.0000976 0.0041218 Fc-epsilon receptor signaling pathway
GO:0032770 10 3 0.0000989 0.0041218 positive regulation of monooxygenase activity
GO:0022008 807 20 0.0001010 0.0041249 neurogenesis
GO:0048646 559 16 0.0001017 0.0041249 anatomical structure formation involved in morphogenesis
GO:0006312 26 4 0.0001036 0.0041456 mitotic recombination
GO:0009628 622 17 0.0001077 0.0042542 response to abiotic stimulus
GO:0032268 1291 27 0.0001091 0.0042542 regulation of cellular protein metabolic process
GO:0070887 1221 26 0.0001109 0.0042705 cellular response to chemical stimulus
GO:1903507 625 17 0.0001141 0.0043405 negative regulation of nucleic acid-templated transcription
GO:0050900 115 7 0.0001219 0.0045690 leukocyte migration
GO:0031324 1229 26 0.0001232 0.0045690 negative regulation of cellular metabolic process
GO:1902679 631 17 0.0001280 0.0046601 negative regulation of RNA biosynthetic process
GO:0007059 116 7 0.0001287 0.0046601 chromosome segregation
GO:0009056 1026 23 0.0001351 0.0047785 catabolic process
GO:0032446 456 14 0.0001351 0.0047785 protein modification by small protein conjugation
GO:0051641 1312 27 0.0001422 0.0049716 cellular localization
GO:0014070 403 13 0.0001448 0.0050023 response to organic cyclic compound
GO:0031327 765 19 0.0001474 0.0050023 negative regulation of cellular biosynthetic process
GO:0006468 519 15 0.0001512 0.0050023 protein phosphorylation
GO:0009894 519 15 0.0001512 0.0050023 regulation of catabolic process
GO:1901698 461 14 0.0001513 0.0050023 response to nitrogen compound
GO:1901575 901 21 0.0001582 0.0051597 organic substance catabolic process
GO:1902531 770 19 0.0001603 0.0051597 regulation of intracellular signal transduction
GO:0008283 353 12 0.0001611 0.0051597 cell proliferation
GO:0009605 903 21 0.0001630 0.0051665 response to external stimulus
GO:1903828 85 6 0.0001672 0.0052430 negative regulation of cellular protein localization
GO:0009890 777 19 0.0001799 0.0055835 negative regulation of biosynthetic process
GO:0006357 913 21 0.0001895 0.0058218 regulation of transcription from RNA polymerase II promoter
GO:0051172 783 19 0.0001983 0.0060332 negative regulation of nitrogen compound metabolic process
GO:0048871 125 7 0.0002047 0.0060944 multicellular organismal homeostasis
GO:0070647 534 15 0.0002058 0.0060944 protein modification by small protein conjugation or removal
GO:0023057 657 17 0.0002064 0.0060944 negative regulation of signaling
GO:0060429 477 14 0.0002149 0.0062863 epithelium development
GO:0051253 661 17 0.0002215 0.0064183 negative regulation of RNA metabolic process
GO:0010243 422 13 0.0002270 0.0064702 response to organonitrogen compound
GO:0071310 994 22 0.0002276 0.0064702 cellular response to organic substance
GO:0048534 314 11 0.0002336 0.0065526 hematopoietic or lymphoid organ development
GO:0043085 860 20 0.0002348 0.0065526 positive regulation of catalytic activity
GO:0010648 665 17 0.0002377 0.0065733 negative regulation of cell communication
GO:0051248 604 16 0.0002450 0.0066722 negative regulation of protein metabolic process
GO:0048585 731 18 0.0002457 0.0066722 negative regulation of response to stimulus
GO:0008104 1071 23 0.0002515 0.0067700 protein localization
GO:0051093 428 13 0.0002602 0.0069426 negative regulation of developmental process
GO:0021520 3 2 0.0002723 0.0070789 spinal cord motor neuron cell fate specification
GO:0021521 3 2 0.0002723 0.0070789 ventral spinal cord interneuron specification
GO:0060573 3 2 0.0002723 0.0070789 cell fate specification involved in pattern specification
GO:0010558 738 18 0.0002756 0.0071048 negative regulation of macromolecule biosynthetic process
GO:0007009 133 7 0.0002995 0.0076568 plasma membrane organization
GO:0034220 435 13 0.0003040 0.0077067 ion transmembrane transport
GO:0044281 1234 25 0.0003238 0.0081397 small molecule metabolic process
GO:0001933 225 9 0.0003318 0.0082649 negative regulation of protein phosphorylation
GO:0031331 275 10 0.0003342 0.0082649 positive regulation of cellular catabolic process
GO:0051353 15 3 0.0003620 0.0088809 positive regulation of oxidoreductase activity
GO:0002520 331 11 0.0003658 0.0089029 immune system development
GO:1903047 505 14 0.0003824 0.0092316 mitotic cell cycle process
GO:0010975 231 9 0.0004020 0.0095691 regulation of neuron projection development
GO:0006310 140 7 0.0004088 0.0095691 DNA recombination
GO:0007173 140 7 0.0004088 0.0095691 epidermal growth factor receptor signaling pathway
GO:0045785 184 8 0.0004089 0.0095691 positive regulation of cell adhesion
GO:0016032 450 13 0.0004196 0.0097431 viral process
GO:0044764 452 13 0.0004375 0.0097455 multi-organism cellular process
GO:0072358 452 13 0.0004375 0.0097455 cardiovascular system development
GO:0072359 452 13 0.0004375 0.0097455 circulatory system development
GO:0009790 512 14 0.0004385 0.0097455 embryo development
GO:0045429 16 3 0.0004424 0.0097455 positive regulation of nitric oxide biosynthetic process
GO:1904407 16 3 0.0004424 0.0097455 positive regulation of nitric oxide metabolic process
GO:0042325 702 17 0.0004428 0.0097455 regulation of phosphorylation
GO:0038127 142 7 0.0004453 0.0097455 ERBB signaling pathway
GO:0042063 102 6 0.0004501 0.0097790 gliogenesis
GO:0006259 455 13 0.0004656 0.0100146 DNA metabolic process
GO:2000379 38 4 0.0004675 0.0100146 positive regulation of reactive oxygen species metabolic process
GO:0021915 103 6 0.0004741 0.0100861 neural tube development
GO:0048878 398 12 0.0004785 0.0101082 chemical homeostasis
GO:0055085 579 15 0.0004832 0.0101378 transmembrane transport
GO:0010506 190 8 0.0005060 0.0104178 regulation of autophagy
GO:0003333 39 4 0.0005170 0.0104178 amino acid transmembrane transport
GO:0009888 779 18 0.0005234 0.0104178 tissue development
GO:0006289 69 5 0.0005246 0.0104178 nucleotide-excision repair
GO:0019953 346 11 0.0005302 0.0104178 sexual reproduction
GO:0006297 17 3 0.0005334 0.0104178 nucleotide-excision repair, DNA gap filling
GO:0055081 17 3 0.0005334 0.0104178 anion homeostasis
GO:0007276 292 10 0.0005347 0.0104178 gamete generation
GO:0001710 4 2 0.0005411 0.0104178 mesodermal cell fate commitment
GO:0021514 4 2 0.0005411 0.0104178 ventral spinal cord interneuron differentiation
GO:0045792 4 2 0.0005411 0.0104178 negative regulation of cell size
GO:0060579 4 2 0.0005411 0.0104178 ventral spinal cord interneuron fate commitment
GO:0060581 4 2 0.0005411 0.0104178 cell fate commitment involved in pattern specification
GO:0038093 147 7 0.0005479 0.0104831 Fc receptor signaling pathway
GO:0010647 851 19 0.0005561 0.0105727 positive regulation of cell communication
GO:0007389 193 8 0.0005612 0.0105851 pattern specification process
GO:0030097 294 10 0.0005637 0.0105851 hemopoiesis
GO:0006811 589 15 0.0005766 0.0107504 ion transport
GO:0042326 243 9 0.0005796 0.0107504 negative regulation of phosphorylation
GO:0045934 720 17 0.0005887 0.0107628 negative regulation of nucleobase-containing compound metabolic process
GO:0001932 655 16 0.0005946 0.0107628 regulation of protein phosphorylation
GO:0008285 351 11 0.0005971 0.0107628 negative regulation of cell proliferation
GO:0032386 351 11 0.0005971 0.0107628 regulation of intracellular transport
GO:0042127 721 17 0.0005979 0.0107628 regulation of cell proliferation
GO:0048285 297 10 0.0006097 0.0109105 organelle fission
GO:0006284 41 4 0.0006272 0.0110919 base-excision repair
GO:0019985 41 4 0.0006272 0.0110919 translesion synthesis
GO:0032201 18 3 0.0006356 0.0111766 telomere maintenance via semi-conservative replication
GO:0036293 151 7 0.0006429 0.0112395 response to decreased oxygen levels
GO:2000377 73 5 0.0006798 0.0117804 regulation of reactive oxygen species metabolic process
GO:0044093 1006 21 0.0006816 0.0117804 positive regulation of molecular function
GO:0031344 302 10 0.0006933 0.0119156 regulation of cell projection organization
GO:0007167 538 14 0.0007128 0.0121716 enzyme linked receptor protein signaling pathway
GO:0010628 939 20 0.0007162 0.0121716 positive regulation of gene expression
GO:0008643 74 5 0.0007235 0.0121963 carbohydrate transport
GO:1901564 940 20 0.0007257 0.0121963 organonitrogen compound metabolic process
GO:0008543 112 6 0.0007390 0.0123518 fibroblast growth factor receptor signaling pathway
GO:0009896 306 10 0.0007668 0.0126532 positive regulation of catabolic process
GO:0048010 75 5 0.0007692 0.0126532 vascular endothelial growth factor receptor signaling pathway
GO:0033993 362 11 0.0007695 0.0126532 response to lipid
GO:0044403 481 13 0.0007800 0.0126880 symbiosis, encompassing mutualism through parasitism
GO:0044419 481 13 0.0007800 0.0126880 interspecies interaction between organisms
GO:0051241 483 13 0.0008102 0.0131097 negative regulation of multicellular organismal process
GO:0000122 424 12 0.0008331 0.0134090 negative regulation of transcription from RNA polymerase II promoter
GO:1903146 115 6 0.0008488 0.0135905 regulation of mitophagy
GO:0006790 206 8 0.0008590 0.0136791 sulfur compound metabolic process
GO:0030182 549 14 0.0008665 0.0136791 neuron differentiation
GO:0019220 814 18 0.0008689 0.0136791 regulation of phosphate metabolic process
GO:0010563 312 10 0.0008890 0.0136791 negative regulation of phosphorus metabolic process
GO:0045936 312 10 0.0008890 0.0136791 negative regulation of phosphate metabolic process
GO:0007422 45 4 0.0008956 0.0136791 peripheral nervous system development
GO:0048665 5 2 0.0008961 0.0136791 neuron fate specification
GO:0071636 5 2 0.0008961 0.0136791 positive regulation of transforming growth factor beta production
GO:1990822 5 2 0.0008961 0.0136791 basic amino acid transmembrane transport
GO:0010638 369 11 0.0008993 0.0136791 positive regulation of organelle organization
GO:0010001 78 5 0.0009194 0.0139139 glial cell differentiation
GO:0022604 314 10 0.0009331 0.0140343 regulation of cell morphogenesis
GO:0051962 260 9 0.0009365 0.0140343 positive regulation of nervous system development
GO:0007169 431 12 0.0009594 0.0143064 transmembrane receptor protein tyrosine kinase signaling pathway
GO:1903827 316 10 0.0009790 0.0145277 regulation of cellular protein localization
GO:0051174 824 18 0.0009979 0.0147360 regulation of phosphorus metabolic process
GO:1903428 21 3 0.0010143 0.0149060 positive regulation of reactive oxygen species biosynthetic process
GO:0051301 318 10 0.0010268 0.0150050 cell division
GO:0001894 80 5 0.0010309 0.0150050 tissue homeostasis
GO:0045596 319 10 0.0010513 0.0151255 negative regulation of cell differentiation
GO:0006301 47 4 0.0010563 0.0151255 postreplication repair
GO:0072527 47 4 0.0010563 0.0151255 pyrimidine-containing compound metabolic process
GO:0009725 436 12 0.0010591 0.0151255 response to hormone
GO:0008064 81 5 0.0010903 0.0154267 regulation of actin polymerization or depolymerization
GO:0046434 81 5 0.0010903 0.0154267 organophosphate catabolic process
GO:0006366 438 12 0.0011013 0.0155099 transcription from RNA polymerase II promoter
GO:0070482 166 7 0.0011210 0.0156976 response to oxygen levels
GO:0001838 82 5 0.0011522 0.0156976 embryonic epithelial tube formation
GO:0030832 82 5 0.0011522 0.0156976 regulation of actin filament length
GO:0072175 82 5 0.0011522 0.0156976 epithelial tube formation
GO:0044344 122 6 0.0011541 0.0156976 cellular response to fibroblast growth factor stimulus
GO:0043010 167 7 0.0011607 0.0156976 camera-type eye development
GO:0000722 22 3 0.0011662 0.0156976 telomere maintenance via recombination
GO:0006298 22 3 0.0011662 0.0156976 mismatch repair
GO:0042220 22 3 0.0011662 0.0156976 response to cocaine
GO:0043491 22 3 0.0011662 0.0156976 protein kinase B signaling
GO:0071774 123 6 0.0012038 0.0161240 response to fibroblast growth factor
GO:0031399 909 19 0.0012135 0.0161240 regulation of protein modification process
GO:1901137 383 11 0.0012138 0.0161240 carbohydrate derivative biosynthetic process
GO:0031400 384 11 0.0012394 0.0163918 negative regulation of protein modification process
GO:1903649 271 9 0.0012505 0.0164676 regulation of cytoplasmic transport
GO:0045184 842 18 0.0012717 0.0166749 establishment of protein localization
GO:0008361 84 5 0.0012838 0.0167606 regulation of cell size
GO:0051224 125 6 0.0013080 0.0170042 negative regulation of protein transport
GO:0014037 23 3 0.0013317 0.0170724 Schwann cell differentiation
GO:0055089 6 2 0.0013357 0.0170724 fatty acid homeostasis
GO:0097011 6 2 0.0013357 0.0170724 cellular response to granulocyte macrophage colony-stimulating factor stimulus
GO:0097012 6 2 0.0013357 0.0170724 response to granulocyte macrophage colony-stimulating factor
GO:0012501 641 15 0.0013495 0.0171563 programmed cell death
GO:0050870 85 5 0.0013536 0.0171563 positive regulation of T cell activation
GO:0000003 449 12 0.0013593 0.0171573 reproduction
GO:0031329 451 12 0.0014112 0.0177387 regulation of cellular catabolic process
GO:0015758 51 4 0.0014365 0.0179094 glucose transport
GO:0060359 51 4 0.0014365 0.0179094 response to ammonium ion
GO:0033365 334 10 0.0014816 0.0183961 protein localization to organelle
GO:0034112 87 5 0.0015015 0.0185380 positive regulation of homotypic cell-cell adhesion
GO:0046329 24 3 0.0015113 0.0185380 negative regulation of JNK cascade
GO:0050999 24 3 0.0015113 0.0185380 regulation of nitric-oxide synthase activity
GO:0071705 279 9 0.0015283 0.0185731 nitrogen compound transport
GO:0001704 52 4 0.0015447 0.0185731 formation of primary germ layer
GO:0006694 52 4 0.0015447 0.0185731 steroid biosynthetic process
GO:0008645 52 4 0.0015447 0.0185731 hexose transport
GO:0015749 52 4 0.0015447 0.0185731 monosaccharide transport
GO:1903039 88 5 0.0015797 0.0189195 positive regulation of leukocyte cell-cell adhesion
GO:0042981 722 16 0.0016430 0.0194332 regulation of apoptotic process
GO:0048584 1006 20 0.0016444 0.0194332 positive regulation of response to stimulus
GO:0010942 339 10 0.0016534 0.0194332 positive regulation of cell death
GO:0030278 89 5 0.0016610 0.0194332 regulation of ossification
GO:0098779 89 5 0.0016610 0.0194332 mitophagy in response to mitochondrial depolarization
GO:0098780 89 5 0.0016610 0.0194332 response to mitochondrial depolarisation
GO:0006271 25 3 0.0017054 0.0197252 DNA strand elongation involved in DNA replication
GO:0022616 25 3 0.0017054 0.0197252 DNA strand elongation
GO:0034405 25 3 0.0017054 0.0197252 response to fluid shear stress
GO:0015031 795 17 0.0017267 0.0198962 protein transport
GO:0043067 727 16 0.0017619 0.0202026 regulation of programmed cell death
GO:0010634 54 4 0.0017778 0.0202026 positive regulation of epithelial cell migration
GO:0007264 402 11 0.0017805 0.0202026 small GTPase mediated signal transduction
GO:0010959 180 7 0.0017849 0.0202026 regulation of metal ion transport
GO:0034613 728 16 0.0017865 0.0202026 cellular protein localization
GO:0035148 91 5 0.0018325 0.0204807 tube formation
GO:1903599 91 5 0.0018325 0.0204807 positive regulation of mitophagy
GO:0015802 7 2 0.0018582 0.0204807 basic amino acid transport
GO:0065005 7 2 0.0018582 0.0204807 protein-lipid complex assembly
GO:0070862 7 2 0.0018582 0.0204807 negative regulation of protein exit from endoplasmic reticulum
GO:0097062 7 2 0.0018582 0.0204807 dendritic spine maintenance
GO:1904153 7 2 0.0018582 0.0204807 negative regulation of retrograde protein transport, ER to cytosol
GO:0006469 134 6 0.0018650 0.0204817 negative regulation of protein kinase activity
GO:1900034 55 4 0.0019031 0.0208181 regulation of cellular response to heat
GO:0042769 26 3 0.0019143 0.0208181 DNA damage response, detection of DNA damage
GO:0010632 92 5 0.0019230 0.0208181 regulation of epithelial cell migration
GO:0016331 92 5 0.0019230 0.0208181 morphogenesis of embryonic epithelium
GO:0070727 734 16 0.0019404 0.0209318 cellular macromolecule localization
GO:0044248 877 18 0.0019901 0.0213694 cellular catabolic process
GO:1901135 600 14 0.0019950 0.0213694 carbohydrate derivative metabolic process
GO:0030203 94 5 0.0021138 0.0225618 glycosaminoglycan metabolic process
GO:0051649 1103 21 0.0021298 0.0225879 establishment of localization in cell
GO:0008219 672 15 0.0021333 0.0225879 cell death
GO:0032768 27 3 0.0021385 0.0225879 regulation of monooxygenase activity
GO:0051173 957 19 0.0021797 0.0229434 positive regulation of nitrogen compound metabolic process
GO:0016265 674 15 0.0021947 0.0230219 death
GO:0010769 187 7 0.0022148 0.0231522 regulation of cell morphogenesis involved in differentiation
GO:0016241 139 6 0.0022434 0.0233385 regulation of macroautophagy
GO:0071495 542 13 0.0022624 0.0233385 cellular response to endogenous stimulus
GO:0044703 415 11 0.0022805 0.0233385 multi-organism reproductive process
GO:0001654 188 7 0.0022822 0.0233385 eye development
GO:0044723 355 10 0.0023144 0.0233385 single-organism carbohydrate metabolic process
GO:0006023 58 4 0.0023153 0.0233385 aminoglycan biosynthetic process
GO:0006024 58 4 0.0023153 0.0233385 glycosaminoglycan biosynthetic process
GO:0009968 610 14 0.0023199 0.0233385 negative regulation of signal transduction
GO:0003002 140 6 0.0023256 0.0233385 regionalization
GO:0032103 189 7 0.0023511 0.0233385 positive regulation of response to external stimulus
GO:0051129 356 10 0.0023619 0.0233385 negative regulation of cellular component organization
GO:0051336 749 16 0.0023746 0.0233385 regulation of hydrolase activity
GO:0009262 28 3 0.0023784 0.0233385 deoxyribonucleotide metabolic process
GO:0010833 28 3 0.0023784 0.0233385 telomere maintenance via telomere lengthening
GO:0030279 28 3 0.0023784 0.0233385 negative regulation of ossification
GO:0032873 28 3 0.0023784 0.0233385 negative regulation of stress-activated MAPK cascade
GO:0043535 28 3 0.0023784 0.0233385 regulation of blood vessel endothelial cell migration
GO:0070303 28 3 0.0023784 0.0233385 negative regulation of stress-activated protein kinase signaling cascade
GO:1902475 28 3 0.0023784 0.0233385 L-alpha-amino acid transmembrane transport
GO:0040011 612 14 0.0023899 0.0233763 locomotion
GO:0048609 358 10 0.0024593 0.0234778 multicellular organismal reproductive process
GO:0009263 8 2 0.0024620 0.0234778 deoxyribonucleotide biosynthetic process
GO:0014067 8 2 0.0024620 0.0234778 negative regulation of phosphatidylinositol 3-kinase signaling
GO:0016559 8 2 0.0024620 0.0234778 peroxisome fission
GO:0032733 8 2 0.0024620 0.0234778 positive regulation of interleukin-10 production
GO:0060795 8 2 0.0024620 0.0234778 cell fate commitment involved in formation of primary germ layer
GO:1904152 8 2 0.0024620 0.0234778 regulation of retrograde protein transport, ER to cytosol
GO:1904293 8 2 0.0024620 0.0234778 negative regulation of ERAD pathway
GO:0060627 244 8 0.0025030 0.0237942 regulation of vesicle-mediated transport
GO:0006022 98 5 0.0025361 0.0239594 aminoglycan metabolic process
GO:0043409 98 5 0.0025361 0.0239594 negative regulation of MAPK cascade
GO:0006955 618 14 0.0026103 0.0245839 immune response
GO:0033673 144 6 0.0026770 0.0250566 negative regulation of kinase activity
GO:1901214 144 6 0.0026770 0.0250566 regulation of neuron death
GO:0002682 689 15 0.0027043 0.0252342 regulation of immune system process
GO:0030155 304 9 0.0027297 0.0253933 regulation of cell adhesion
GO:0022409 100 5 0.0027688 0.0256013 positive regulation of cell-cell adhesion
GO:0045765 100 5 0.0027688 0.0256013 regulation of angiogenesis
GO:0090317 61 4 0.0027851 0.0256740 negative regulation of intracellular protein transport
GO:0032504 366 10 0.0028814 0.0264814 multicellular organism reproduction
GO:0000725 62 4 0.0029552 0.0270778 recombinational repair
GO:0045087 494 12 0.0029896 0.0273101 innate immune response
GO:0043087 370 10 0.0031132 0.0283171 regulation of GTPase activity
GO:0051044 9 2 0.0031455 0.0283171 positive regulation of membrane protein ectodomain proteolysis
GO:0071243 9 2 0.0031455 0.0283171 cellular response to arsenic-containing substance
GO:0006915 631 14 0.0031458 0.0283171 apoptotic process
GO:0016239 103 5 0.0031463 0.0283171 positive regulation of macroautophagy
GO:0001666 149 6 0.0031706 0.0283973 response to hypoxia
GO:0098655 311 9 0.0031739 0.0283973 cation transmembrane transport
GO:0044702 498 12 0.0031899 0.0284217 single organism reproductive process
GO:0001707 31 3 0.0031953 0.0284217 mesoderm formation
GO:0010941 773 16 0.0032364 0.0287026 regulation of cell death
GO:0006979 201 7 0.0033106 0.0290739 response to oxidative stress
GO:0001843 64 4 0.0033165 0.0290739 neural tube closure
GO:0010594 64 4 0.0033165 0.0290739 regulation of endothelial cell migration
GO:0060606 64 4 0.0033165 0.0290739 tube closure
GO:1902532 256 8 0.0033552 0.0293290 negative regulation of intracellular signal transduction
GO:0032269 568 13 0.0033770 0.0293448 negative regulation of cellular protein metabolic process
GO:0032104 151 6 0.0033859 0.0293448 regulation of response to extracellular stimulus
GO:0032107 151 6 0.0033859 0.0293448 regulation of response to nutrient levels
GO:0032106 105 5 0.0034178 0.0294529 positive regulation of response to extracellular stimulus
GO:0032109 105 5 0.0034178 0.0294529 positive regulation of response to nutrient levels
GO:0050776 439 11 0.0035010 0.0297170 regulation of immune response
GO:0015807 32 3 0.0035012 0.0297170 L-amino acid transport
GO:0031294 32 3 0.0035012 0.0297170 lymphocyte costimulation
GO:0031295 32 3 0.0035012 0.0297170 T cell costimulation
GO:0071897 65 4 0.0035079 0.0297170 DNA biosynthetic process
GO:1903707 65 4 0.0035079 0.0297170 negative regulation of hemopoiesis
GO:0007423 258 8 0.0035168 0.0297170 sensory organ development
GO:0006508 640 14 0.0035670 0.0300575 proteolysis
GO:0032956 153 6 0.0036120 0.0303528 regulation of actin cytoskeleton organization
GO:0055114 574 13 0.0036892 0.0309159 oxidation-reduction process
GO:0016925 66 4 0.0037066 0.0309768 protein sumoylation
GO:0048332 33 3 0.0038245 0.0317414 mesoderm morphogenesis
GO:0009612 108 5 0.0038559 0.0317414 response to mechanical stimulus
GO:0043065 321 9 0.0039055 0.0317414 positive regulation of apoptotic process
GO:0009223 10 2 0.0039072 0.0317414 pyrimidine deoxyribonucleotide catabolic process
GO:0032653 10 2 0.0039072 0.0317414 regulation of interleukin-10 production
GO:0048333 10 2 0.0039072 0.0317414 mesodermal cell differentiation
GO:0048710 10 2 0.0039072 0.0317414 regulation of astrocyte differentiation
GO:0070861 10 2 0.0039072 0.0317414 regulation of protein exit from endoplasmic reticulum
GO:0014020 67 4 0.0039129 0.0317414 primary neural tube formation
GO:0036294 67 4 0.0039129 0.0317414 cellular response to decreased oxygen levels
GO:1903650 67 4 0.0039129 0.0317414 negative regulation of cytoplasmic transport
GO:1901342 109 5 0.0040105 0.0324468 regulation of vasculature development
GO:0030833 68 4 0.0041268 0.0332990 regulation of actin filament polymerization
GO:0043068 324 9 0.0041489 0.0333889 positive regulation of programmed cell death
GO:0071103 110 5 0.0041695 0.0334659 DNA conformation change
GO:0044802 450 11 0.0042128 0.0337243 single-organism membrane organization
GO:0032270 724 15 0.0042821 0.0341894 positive regulation of cellular protein metabolic process
GO:0016567 388 10 0.0043470 0.0345800 protein ubiquitination
GO:0043086 452 11 0.0043538 0.0345800 negative regulation of catalytic activity
GO:0007010 519 12 0.0044282 0.0350793 cytoskeleton organization
GO:0006367 160 6 0.0044922 0.0354943 transcription initiation from RNA polymerase II promoter
GO:0071345 269 8 0.0045164 0.0355608 cellular response to cytokine stimulus
GO:0002260 35 3 0.0045240 0.0355608 lymphocyte homeostasis
GO:0051090 213 7 0.0045437 0.0356236 regulation of sequence-specific DNA binding transcription factor activity
GO:0043549 457 11 0.0047228 0.0363616 regulation of kinase activity
GO:0006244 11 2 0.0047454 0.0363616 pyrimidine nucleotide catabolic process
GO:0009130 11 2 0.0047454 0.0363616 pyrimidine nucleoside monophosphate biosynthetic process
GO:0021513 11 2 0.0047454 0.0363616 spinal cord dorsal/ventral patterning
GO:0030261 11 2 0.0047454 0.0363616 chromosome condensation
GO:0044030 11 2 0.0047454 0.0363616 regulation of DNA methylation
GO:0045453 11 2 0.0047454 0.0363616 bone resorption
GO:0048009 11 2 0.0047454 0.0363616 insulin-like growth factor receptor signaling pathway
GO:0051043 11 2 0.0047454 0.0363616 regulation of membrane protein ectodomain proteolysis
GO:0043547 331 9 0.0047631 0.0364057 positive regulation of GTPase activity
GO:1903825 71 4 0.0048156 0.0367147 organic acid transmembrane transport
GO:0002088 36 3 0.0049008 0.0370855 lens development in camera-type eye
GO:0051341 36 3 0.0049008 0.0370855 regulation of oxidoreductase activity
GO:0071260 36 3 0.0049008 0.0370855 cellular response to mechanical stimulus
GO:0001101 163 6 0.0049142 0.0370946 response to acid chemical
GO:0005975 460 11 0.0049559 0.0373162 carbohydrate metabolic process
GO:0051924 115 5 0.0050324 0.0376742 regulation of calcium ion transport
GO:0010720 274 8 0.0050372 0.0376742 positive regulation of cell development
GO:0044092 596 13 0.0050406 0.0376742 negative regulation of molecular function
GO:1903510 72 4 0.0050614 0.0377370 mucopolysaccharide metabolic process
GO:0032880 529 12 0.0051401 0.0382302 regulation of protein localization
GO:1901700 668 14 0.0051812 0.0384417 response to oxygen-containing compound
GO:0051251 116 5 0.0052191 0.0386292 positive regulation of lymphocyte activation
GO:0010595 37 3 0.0052961 0.0390090 positive regulation of endothelial cell migration
GO:0014013 37 3 0.0052961 0.0390090 regulation of gliogenesis
GO:0071453 73 4 0.0053154 0.0390565 cellular response to oxygen levels
GO:0051249 166 6 0.0053647 0.0392727 regulation of lymphocyte activation
GO:0051345 532 12 0.0053706 0.0392727 positive regulation of hydrolase activity
GO:0034762 220 7 0.0054074 0.0393756 regulation of transmembrane transport
GO:0010508 117 5 0.0054107 0.0393756 positive regulation of autophagy
GO:0048468 890 17 0.0054235 0.0393756 cell development
GO:0000280 278 8 0.0054861 0.0397347 nuclear division
GO:0009129 12 2 0.0056587 0.0405271 pyrimidine nucleoside monophosphate metabolic process
GO:0043536 12 2 0.0056587 0.0405271 positive regulation of blood vessel endothelial cell migration
GO:0071498 12 2 0.0056587 0.0405271 cellular response to fluid shear stress
GO:0071634 12 2 0.0056587 0.0405271 regulation of transforming growth factor beta production
GO:0042493 222 7 0.0056754 0.0405271 response to drug
GO:0044772 222 7 0.0056754 0.0405271 mitotic cell cycle phase transition
GO:0001776 38 3 0.0057100 0.0405835 leukocyte homeostasis
GO:0006220 38 3 0.0057100 0.0405835 pyrimidine nucleotide metabolic process
GO:2001235 119 5 0.0058085 0.0411879 positive regulation of apoptotic signaling pathway
GO:0022407 169 6 0.0058447 0.0412800 regulation of cell-cell adhesion
GO:0001841 75 4 0.0058487 0.0412800 neural tube formation
GO:0051050 471 11 0.0058897 0.0414730 positive regulation of transport
GO:0051276 540 12 0.0060259 0.0423343 chromosome organization
GO:0051254 826 16 0.0060748 0.0425799 positive regulation of RNA metabolic process
GO:0044770 225 7 0.0060959 0.0426292 cell cycle phase transition
GO:0071300 39 3 0.0061427 0.0428582 cellular response to retinoic acid
GO:0050769 226 7 0.0062411 0.0434450 positive regulation of neurogenesis
GO:0051338 543 12 0.0062874 0.0436672 regulation of transferase activity
GO:0030100 122 5 0.0064434 0.0446488 regulation of endocytosis
GO:0002683 173 6 0.0065326 0.0450617 negative regulation of immune system process
GO:0071396 173 6 0.0065326 0.0450617 cellular response to lipid
GO:0044085 1218 21 0.0066446 0.0453403 cellular component biogenesis
GO:0009219 13 2 0.0066456 0.0453403 pyrimidine deoxyribonucleotide metabolic process
GO:0015949 13 2 0.0066456 0.0453403 nucleobase-containing small molecule interconversion
GO:0021511 13 2 0.0066456 0.0453403 spinal cord patterning
GO:0048870 413 10 0.0066677 0.0453403 cell motility
GO:0051674 413 10 0.0066677 0.0453403 localization of cell
GO:0009653 1140 20 0.0066806 0.0453403 anatomical structure morphogenesis
GO:0002768 229 7 0.0066922 0.0453403 immune response-regulating cell surface receptor signaling pathway
GO:0032387 78 4 0.0067136 0.0453842 negative regulation of intracellular transport
GO:0002764 288 8 0.0067418 0.0454449 immune response-regulating signaling pathway
GO:0016482 480 11 0.0067525 0.0454449 cytoplasmic transport
GO:0022414 549 12 0.0068373 0.0458838 reproductive process
GO:0031667 230 7 0.0068479 0.0458838 response to nutrient levels
GO:0050863 124 5 0.0068927 0.0460829 regulation of T cell activation
GO:0048666 482 11 0.0069571 0.0464109 neuron development
GO:0071496 176 6 0.0070858 0.0471664 cellular response to external stimulus
GO:0043414 125 5 0.0071254 0.0473266 macromolecule methylation
GO:0031328 918 17 0.0073053 0.0484157 positive regulation of cellular biosynthetic process
GO:0007067 233 7 0.0073310 0.0484800 mitotic nuclear division
GO:0009895 126 5 0.0073636 0.0485900 negative regulation of catabolic process
GO:0030030 626 13 0.0074971 0.0493639 cell projection organization
GO:0006283 42 3 0.0075562 0.0496460 transcription-coupled nucleotide-excision repair
GO:0000165 127 5 0.0076072 0.0497682 MAPK cascade
GO:0042177 81 4 0.0076593 0.0497682 negative regulation of protein catabolic process
GO:0030855 235 7 0.0076668 0.0497682 epithelial cell differentiation
GO:0030163 357 9 0.0076846 0.0497682 protein catabolic process
GO:0021522 14 2 0.0077046 0.0497682 spinal cord motor neuron differentiation
GO:0071825 14 2 0.0077046 0.0497682 protein-lipid complex subunit organization
GO:0097061 14 2 0.0077046 0.0497682 dendritic spine organization
GO:0045859 422 10 0.0077057 0.0497682 regulation of protein kinase activity
term_id proteins hits pvalue pvalue_fdr term_description
GO:0005783 966 25 0.0000225 0.0085946 endoplasmic reticulum
GO:0098588 1415 31 0.0000561 0.0102123 bounding membrane of organelle
GO:0044432 677 19 0.0000802 0.0102123 endoplasmic reticulum part
GO:0048471 429 14 0.0001556 0.0133113 perinuclear region of cytoplasm
GO:0044459 1098 25 0.0001742 0.0133113 plasma membrane part
GO:0045171 30 4 0.0002443 0.0155513 intercellular bridge
GO:0005789 577 16 0.0003385 0.0174051 endoplasmic reticulum membrane
GO:0042175 583 16 0.0003792 0.0174051 nuclear outer membrane-endoplasmic reticulum membrane network
GO:0042995 1028 23 0.0004101 0.0174051 cell projection
GO:0005635 273 10 0.0005636 0.0194581 nuclear envelope
GO:0044454 225 9 0.0005669 0.0194581 nuclear chromosome part
GO:0031226 671 17 0.0006192 0.0194581 intrinsic component of plasma membrane
GO:0043005 554 15 0.0006622 0.0194581 neuron projection
GO:0016607 144 7 0.0007497 0.0204556 nuclear speck
GO:0044427 400 12 0.0009576 0.0239731 chromosomal part
GO:0005887 641 16 0.0010440 0.0239731 integral component of plasma membrane
GO:0000228 246 9 0.0010669 0.0239731 nuclear chromosome
GO:0016604 252 9 0.0012617 0.0267751 nuclear body
GO:0005730 603 15 0.0015425 0.0310120 nucleolus
GO:0098796 546 14 0.0016645 0.0317918 membrane protein complex
GO:0097458 686 16 0.0020861 0.0379468 neuron part
GO:0005694 449 12 0.0025202 0.0437590 chromosome
term_id proteins hits pvalue pvalue_fdr term_description
GO:0003677 1361 37 0.0000000 0.0000001 DNA binding
GO:0016740 1373 36 0.0000000 0.0000003 transferase activity
GO:0019899 881 25 0.0000001 0.0000204 enzyme binding
GO:0032559 1054 27 0.0000003 0.0000308 adenyl ribonucleotide binding
GO:0030554 1059 27 0.0000003 0.0000308 adenyl nucleotide binding
GO:0016772 640 20 0.0000005 0.0000463 transferase activity, transferring phosphorus-containing groups
GO:0005524 1031 26 0.0000006 0.0000463 ATP binding
GO:0042802 597 19 0.0000008 0.0000483 identical protein binding
GO:0032555 1263 29 0.0000008 0.0000483 purine ribonucleotide binding
GO:0017076 1269 29 0.0000009 0.0000483 purine nucleotide binding
GO:0032553 1272 29 0.0000010 0.0000483 ribonucleotide binding
GO:0035639 1240 28 0.0000018 0.0000811 purine ribonucleoside triphosphate binding
GO:0032550 1248 28 0.0000021 0.0000811 purine ribonucleoside binding
GO:0001883 1251 28 0.0000022 0.0000811 purine nucleoside binding
GO:0032549 1252 28 0.0000022 0.0000811 ribonucleoside binding
GO:0001882 1256 28 0.0000023 0.0000811 nucleoside binding
GO:0046914 891 22 0.0000066 0.0002148 transition metal ion binding
GO:0097367 1419 29 0.0000082 0.0002532 carbohydrate derivative binding
GO:0015075 390 13 0.0000289 0.0008454 ion transmembrane transporter activity
GO:0022857 459 14 0.0000376 0.0010131 transmembrane transporter activity
GO:0016301 521 15 0.0000383 0.0010131 kinase activity
GO:0004674 300 11 0.0000516 0.0012563 protein serine/threonine kinase activity
GO:0016773 473 14 0.0000521 0.0012563 phosphotransferase activity, alcohol group as acceptor
GO:0004842 205 9 0.0000642 0.0014753 ubiquitin-protein transferase activity
GO:0022891 423 13 0.0000665 0.0014753 substrate-specific transmembrane transporter activity
GO:0000989 374 12 0.0000849 0.0018127 transcription factor activity, transcription factor binding
GO:0019787 214 9 0.0000893 0.0018152 ubiquitin-like protein transferase activity
GO:0000988 377 12 0.0000916 0.0018152 transcription factor activity, protein binding
GO:0008270 769 18 0.0000950 0.0018172 zinc ion binding
GO:0022892 510 14 0.0001157 0.0021404 substrate-specific transporter activity
GO:0001071 580 15 0.0001271 0.0022049 nucleic acid binding transcription factor activity
GO:0003700 580 15 0.0001271 0.0022049 transcription factor activity, sequence-specific DNA binding
GO:0004672 396 12 0.0001451 0.0024093 protein kinase activity
GO:0005088 94 6 0.0001476 0.0024093 Ras guanyl-nucleotide exchange factor activity
GO:0005215 597 15 0.0001741 0.0027299 transporter activity
GO:0019900 288 10 0.0001771 0.0027299 kinase binding
GO:0003712 356 11 0.0002327 0.0034908 transcription cofactor activity
GO:0015171 38 4 0.0002913 0.0042549 amino acid transmembrane transporter activity
GO:0098772 703 16 0.0003217 0.0045773 molecular function regulator
GO:0001047 71 5 0.0003386 0.0046979 core promoter binding
GO:0019901 260 9 0.0003819 0.0051692 protein kinase binding
GO:0003836 4 2 0.0004219 0.0055751 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity
GO:0061650 20 3 0.0006095 0.0078671 ubiquitin-like protein conjugating enzyme activity
GO:0015174 5 2 0.0006993 0.0088201 basic amino acid transmembrane transporter activity
GO:0003684 51 4 0.0009056 0.0111689 damaged DNA binding
GO:0042605 6 2 0.0010430 0.0125846 peptide antigen binding
GO:0003887 25 3 0.0011922 0.0137843 DNA-directed DNA polymerase activity
GO:0034061 25 3 0.0011922 0.0137843 DNA polymerase activity
GO:0044877 647 14 0.0012380 0.0138420 macromolecular complex binding
GO:0019904 248 8 0.0012656 0.0138420 protein domain specific binding
GO:0008324 308 9 0.0012720 0.0138420 cation transmembrane transporter activity
GO:0016788 439 11 0.0013187 0.0140741 hydrolase activity, acting on ester bonds
GO:0016787 1380 23 0.0013945 0.0146030 hydrolase activity
GO:0016874 314 9 0.0014530 0.0149333 ligase activity
GO:0015179 28 3 0.0016668 0.0168192 L-amino acid transmembrane transporter activity
GO:0046943 61 4 0.0017712 0.0175543 carboxylic acid transmembrane transporter activity
GO:0005342 62 4 0.0018811 0.0183156 organic acid transmembrane transporter activity
GO:0061630 108 5 0.0022564 0.0215913 ubiquitin protein ligase activity
GO:0061659 111 5 0.0025424 0.0239155 ubiquitin-like protein ligase activity
GO:0046332 36 3 0.0034574 0.0319806 SMAD binding
GO:0005085 122 5 0.0038182 0.0341793 guanyl-nucleotide exchange factor activity
GO:0008509 122 5 0.0038182 0.0341793 anion transmembrane transporter activity
GO:0003682 298 8 0.0039372 0.0346846 chromatin binding
GO:0030674 78 4 0.0043333 0.0375776 protein binding, bridging
GO:0031491 12 2 0.0044387 0.0378998 nucleosome binding
GO:0008514 79 4 0.0045348 0.0381333 organic anion transmembrane transporter activity
GO:0004536 40 3 0.0046675 0.0386640 deoxyribonuclease activity
GO:0008187 13 2 0.0052167 0.0410795 poly-pyrimidine tract binding
GO:0016628 13 2 0.0052167 0.0410795 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
GO:0005216 187 6 0.0052213 0.0410795 ion channel activity
GO:0030234 526 11 0.0052552 0.0410795 enzyme regulator activity
GO:0022838 190 6 0.0056347 0.0426682 substrate-specific channel activity
GO:0022890 252 7 0.0057248 0.0426682 inorganic cation transmembrane transporter activity
GO:0019200 14 2 0.0060525 0.0426682 carbohydrate kinase activity
GO:0015267 194 6 0.0062225 0.0426682 channel activity
GO:0022803 194 6 0.0062225 0.0426682 passive transmembrane transporter activity
GO:0060090 91 4 0.0074616 0.0426682 binding, bridging
GO:0003714 144 5 0.0076435 0.0426682 transcription corepressor activity
GO:0005057 93 4 0.0080464 0.0426682 receptor signaling protein activity
GO:0003777 49 3 0.0082351 0.0426682 microtubule motor activity
GO:0005200 49 3 0.0082351 0.0426682 structural constituent of cytoskeleton
GO:0001010 1 1 0.0084568 0.0426682 transcription factor activity, sequence-specific DNA binding transcription factor recruiting
GO:0003882 1 1 0.0084568 0.0426682 CDP-diacylglycerol-serine O-phosphatidyltransferase activity
GO:0004170 1 1 0.0084568 0.0426682 dUTP diphosphatase activity
GO:0004499 1 1 0.0084568 0.0426682 N,N-dimethylaniline monooxygenase activity
GO:0004632 1 1 0.0084568 0.0426682 phosphopantothenate–cysteine ligase activity
GO:0004748 1 1 0.0084568 0.0426682 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
GO:0004808 1 1 0.0084568 0.0426682 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GO:0008118 1 1 0.0084568 0.0426682 N-acetyllactosaminide alpha-2,3-sialyltransferase activity
GO:0008482 1 1 0.0084568 0.0426682 sulfite oxidase activity
GO:0015327 1 1 0.0084568 0.0426682 cystine:glutamate antiporter activity
GO:0015328 1 1 0.0084568 0.0426682 cystine secondary active transmembrane transporter activity
GO:0016728 1 1 0.0084568 0.0426682 oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor
GO:0030911 1 1 0.0084568 0.0426682 TPR domain binding
GO:0033328 1 1 0.0084568 0.0426682 peroxisome membrane targeting sequence binding
GO:0033858 1 1 0.0084568 0.0426682 N-acetylgalactosamine kinase activity
GO:0033867 1 1 0.0084568 0.0426682 Fas-activated serine/threonine kinase activity
GO:0033882 1 1 0.0084568 0.0426682 choloyl-CoA hydrolase activity
GO:0034647 1 1 0.0084568 0.0426682 histone demethylase activity (H3-trimethyl-K4 specific)
GO:0036105 1 1 0.0084568 0.0426682 peroxisome membrane class-1 targeting sequence binding
GO:0043199 1 1 0.0084568 0.0426682 sulfate binding
GO:0046811 1 1 0.0084568 0.0426682 histone deacetylase inhibitor activity
GO:0046977 1 1 0.0084568 0.0426682 TAP binding
GO:0047288 1 1 0.0084568 0.0426682 monosialoganglioside sialyltransferase activity
GO:0048408 1 1 0.0084568 0.0426682 epidermal growth factor binding
GO:0050613 1 1 0.0084568 0.0426682 delta14-sterol reductase activity
GO:0052815 1 1 0.0084568 0.0426682 medium-chain acyl-CoA hydrolase activity
GO:0061656 1 1 0.0084568 0.0426682 SUMO conjugating enzyme activity
GO:0061731 1 1 0.0084568 0.0426682 ribonucleoside-diphosphate reductase activity
GO:1901680 1 1 0.0084568 0.0426682 sulfur-containing amino acid secondary active transmembrane transporter activity
GO:0046873 208 6 0.0086337 0.0429156 metal ion transmembrane transporter activity
GO:0072509 95 4 0.0086605 0.0429156 divalent inorganic cation transmembrane transporter activity
GO:0042803 342 8 0.0087981 0.0432121 protein homodimerization activity
GO:0015035 17 2 0.0088964 0.0433114 protein disulfide oxidoreductase activity
GO:0003723 1073 17 0.0095983 0.0463224 RNA binding

Cluster the pathways with PathCluster. This takes a lot of time…. Eval==F to skip this when knitting.

qPCR results for ZNF189 (Fig. 2)

Fitted values extracted from DEXSeq, as DEXSeq identified DTU gene ZNF189

## [1] "extracting counts from the provided count object assuming it is a dex object"
## [1] "extracting counts from DEXSeq"
## [1] "extracting fitted couns from DEXSeq"
## [1] "extracting counts from the provided count object assuming it is a dex object"
## [1] "extracting counts from DEXSeq"
## [1] "extracting fitted couns from DEXSeq"
plots <- append(plots1,plots2)
# read qPCR results
znfLab <- read.csv(znfLabFile, sep = "\t") %>%
    dplyr::select(tx_id, perc, condition, tx_biotype, sample_id)
colnames(znfLab) <- c("transcript_id", "frac", "condition", "tx_biotype", "sample_id")
znfLab %<>% dplyr::mutate(tx_id_label = (paste0(transcript_id, "\nprotein_coding"))) %>%
        dplyr::mutate(countType = rep("qPCR", nrow(znfLab))) %>%
        dplyr::mutate(condition =  ifelse(condition == "CT", 0, 1)) 
# Extract counts from plot obj
dfs <- lapply(seq(1, length(plots)),function(i){
 subset(plots[[i]]$data, sample_id %in% unique(znfLab$sample_id)) %>%
     dplyr::select(transcript_id, sample_id, condition, frac, tx_id_label, countType)
})
# Filtered out transcript: "ENST00000496104" it is not expressed in replication
dfs[[1]] <- subset(dfs[[1]],transcript_id != "ENST00000496104")  
dfs[[2]] <- subset(dfs[[2]],transcript_id != "ENST00000496104")  
# Combine lab and insilico df 
df <- gdata::combine(dfs[[1]], dfs[[2]]) %>%
    dplyr::select(transcript_id, frac, condition, tx_id_label, countType)
znfLab %<>% dplyr::select(transcript_id, frac, condition, tx_id_label, countType)
df <- gdata::combine(df, znfLab, names=c("RNASeq","qPCR")) %>% dplyr::filter(!grepl("dge", countType))
# plot function 
makeLabPlot <-function(df, tool, tag, legend = F) {
 p <- ggplot(subset(df, countType == "qPCR" | countType == "observed_tx"),
         aes(x = condition, y = frac)) +
    geom_jitter(position = position_jitter(0.1), size = 1.5) + 
    stat_summary(fun.y = median, geom = "errorbar", aes(ymax = ..y.., ymin = ..y..,col="red"),
                 width = .75, linetype = "dashed") +
    stat_summary(fun.y = median, colour="red", geom="line", aes(group = 1)) +
    facet_grid(cols = vars(tx_id_label), rows = vars(source), scales = "free_y") +
    geom_boxplot(data = subset(df, countType == "fitted_tx") %>%
                    dplyr::group_by(condition, transcript_id) %>%
                dplyr::mutate(mean = median(frac)),
            aes(x = condition, y = mean, col = "blue"),
            inherit.aes = F, size = 0.2) + 
    labs(x = "Condition", y = "Relative abundance",
         title = "", tag = tag, col = "Median of: ") +
    theme_bw() +
    scale_x_discrete(labels = c("0" = "CT", "1" = "PD")) +
    scale_color_manual(values = c("red" = "red", "blue" = "blue"),
        labels = c("red" = "observed values\n (black points)",
           "blue" = paste0("fitted values - ", tool, " \n (points not displayed)"))) +
    theme(panel.spacing = unit(1, "lines")) +
    theme(strip.background = element_rect(fill = "black"))+
    theme(strip.text = element_text(color = "white", face = "bold"))  
 if (legend) {
  p <- p + theme(legend.position = "bottom")
 } else {
  p <- p + theme(legend.position = "none")
 }
 return(p)
}
# Make the plot 
znf <- makeLabPlot(df = df, tool = "DEXSeq", tag = "")    
znf

## png 
##   2

Differences in DTU genes due to cell correction with oligo and microglia estimates

## png 
##   2

Supplement tables for all dtu genes and events

tool tx_id gene_pvalueStageR tx_pvalueStageR nom_pval gene_id gene_name tx_biotype l2fc
DRIMSeq ENST00000464157 0.0009145 0.0000098 0.0000004 ENSG00000107331 ABCA2 processed_transcript 1.8203240
DRIMSeq ENST00000428549 0.0071572 0.0314952 0.0004393 ENSG00000141338 ABCA8 retained_intron 1.0576213
DRIMSeq ENST00000280560 0.0110404 0.0002220 0.0000023 ENSG00000150967 ABCB9 protein_coding -2.6782652
DRIMSeq ENST00000442687 0.0495117 0.0000000 0.0020474 ENSG00000239642 AC034228.7 transcribed_unprocessed_pseudogene -1.5713896
DRIMSeq ENST00000446743 0.0495117 0.0000000 0.0020474 ENSG00000239642 AC034228.7 processed_transcript 1.5713896
DRIMSeq ENST00000430844 0.0440606 0.0082266 0.0003443 ENSG00000228010 AC073343.13 antisense -1.0155638
DRIMSeq ENST00000497320 0.0199445 0.0065538 0.0002743 ENSG00000242474 AC093627.9 lincRNA -1.1730599
DRIMSeq ENST00000452171 0.0154020 0.0336502 0.0007041 ENSG00000060971 ACAA1 protein_coding -1.2643208
DRIMSeq ENST00000350303 0.0388816 0.0057169 0.0000797 ENSG00000072778 ACADVL protein_coding -1.3504959
DRIMSeq ENST00000379923 0.0240217 0.0023476 0.0000982 ENSG00000122729 ACO1 protein_coding -1.3784695
DRIMSeq ENST00000217455 0.0348237 0.0000000 0.0010323 ENSG00000101473 ACOT8 protein_coding -0.9326298
DRIMSeq ENST00000484975 0.0348237 0.0000000 0.0010323 ENSG00000101473 ACOT8 retained_intron 0.9326298
DRIMSeq ENST00000160382 0.0370298 0.0048993 0.0001025 ENSG00000077080 ACTL6B protein_coding -0.8918091
DRIMSeq ENST00000271836 0.0420729 0.0079299 0.0001659 ENSG00000143537 ADAM15 protein_coding -1.5311314
DRIMSeq ENST00000381312 0.0488893 0.0293910 0.0006150 ENSG00000185736 ADARB2 protein_coding -0.8717468
DRIMSeq ENST00000373443 0.0151134 0.0005682 0.0000079 ENSG00000142920 ADC protein_coding -1.8158726
DRIMSeq ENST00000285518 0.0496424 0.0000000 0.0020630 ENSG00000155189 AGPAT5 protein_coding -0.8790660
DRIMSeq ENST00000530716 0.0496424 0.0000000 0.0020630 ENSG00000155189 AGPAT5 processed_transcript 0.8790660
DRIMSeq ENST00000475985 0.0114150 0.0028440 0.0000595 ENSG00000117448 AKR1A1 processed_transcript 1.5196852
DRIMSeq ENST00000407796 0.0154087 0.0000000 0.0002420 ENSG00000142208 AKT1 protein_coding -1.1873011
DRIMSeq ENST00000555380 0.0154087 0.0000000 0.0002420 ENSG00000142208 AKT1 protein_coding 1.1873011
DRIMSeq ENST00000344175 0.0061001 0.0000332 0.0000005 ENSG00000204673 AKT1S1 protein_coding -1.8242347
DRIMSeq ENST00000394458 0.0232151 0.0000000 0.0004974 ENSG00000160117 ANKLE1 protein_coding 1.4685539
DRIMSeq ENST00000404085 0.0232151 0.0000000 0.0004974 ENSG00000160117 ANKLE1 protein_coding -1.4685539
DRIMSeq ENST00000307518 0.0277435 0.0190510 0.0007972 ENSG00000165887 ANKRD2 protein_coding 3.6848343
DRIMSeq ENST00000265748 0.0020017 0.0002783 0.0000116 ENSG00000011426 ANLN protein_coding -1.4866235
DRIMSeq ENST00000441696 0.0020017 0.0363081 0.0015194 ENSG00000011426 ANLN nonsense_mediated_decay 1.5410206
DRIMSeq ENST00000597643 0.0151134 0.0000000 0.0002282 ENSG00000074855 ANO8 nonsense_mediated_decay 1.2195595
DRIMSeq ENST00000159087 0.0151134 0.0000000 0.0002282 ENSG00000074855 ANO8 protein_coding -1.2195595
DRIMSeq ENST00000394295 0.0215993 0.0082736 0.0001731 ENSG00000196975 ANXA4 protein_coding -0.8072394
DRIMSeq ENST00000336418 0.0456265 0.0000000 0.0017366 ENSG00000157823 AP3S2 protein_coding 3.0522100
DRIMSeq ENST00000560940 0.0456265 0.0000000 0.0017366 ENSG00000157823 AP3S2 protein_coding -3.0522100
DRIMSeq ENST00000527830 0.0440348 0.0069459 0.0002907 ENSG00000149089 APIP processed_transcript -2.8756330
DRIMSeq ENST00000447138 0.0140365 0.0000000 0.0001987 ENSG00000101474 APMAP protein_coding -1.3020439
DRIMSeq ENST00000217456 0.0140365 0.0000000 0.0001987 ENSG00000101474 APMAP protein_coding 1.3020439
DRIMSeq ENST00000426324 0.0302169 0.0060117 0.0002516 ENSG00000198931 APRT protein_coding -1.1216256
DRIMSeq ENST00000426335 0.0154087 0.0000000 0.0002412 ENSG00000149182 ARFGAP2 protein_coding 1.0012903
DRIMSeq ENST00000524782 0.0154087 0.0000000 0.0002412 ENSG00000149182 ARFGAP2 protein_coding -1.0012903
DRIMSeq ENST00000582520 0.0232151 0.0115668 0.0001613 ENSG00000141522 ARHGDIA processed_transcript 2.0332131
DRIMSeq ENST00000452522 0.0337902 0.0096816 0.0004051 ENSG00000074964 ARHGEF10L protein_coding -1.0385160
DRIMSeq ENST00000541725 0.0396600 0.0221211 0.0003086 ENSG00000105676 ARMC6 protein_coding 1.9490360
DRIMSeq ENST00000494015 0.0388082 0.0050847 0.0002128 ENSG00000114098 ARMC8 retained_intron 1.7739126
DRIMSeq ENST00000374007 0.0240060 0.0000000 0.0005422 ENSG00000204147 ASAH2B protein_coding -0.9347490
DRIMSeq ENST00000185907 0.0240060 0.0000000 0.0005422 ENSG00000204147 ASAH2B protein_coding 0.9347490
DRIMSeq ENST00000380920 0.0471741 0.0105085 0.0004397 ENSG00000141505 ASGR1 protein_coding -1.5775702
DRIMSeq ENST00000554151 0.0130174 0.0023241 0.0000486 ENSG00000066739 ATG2B processed_transcript 0.9814713
DRIMSeq ENST00000359933 0.0130174 0.0100159 0.0002096 ENSG00000066739 ATG2B protein_coding -0.7504442
DRIMSeq ENST00000557311 0.0065356 0.0002934 0.0000041 ENSG00000066427 ATXN3 protein_coding -1.5790737
DRIMSeq ENST00000377526 0.0141822 0.0007264 0.0000304 ENSG00000115307 AUP1 protein_coding -1.1043431
DRIMSeq ENST00000570947 0.0005260 0.0000184 0.0000004 ENSG00000175711 B3GNTL1 processed_transcript 4.7808994
DRIMSeq ENST00000261499 0.0094813 0.0040775 0.0000569 ENSG00000108641 B9D1 protein_coding -1.0057055
DRIMSeq ENST00000369541 0.0456265 0.0000000 0.0017278 ENSG00000116752 BCAS2 protein_coding -0.9433829
DRIMSeq ENST00000485021 0.0456265 0.0000000 0.0017278 ENSG00000116752 BCAS2 processed_transcript 0.9433829
DRIMSeq ENST00000264381 0.0140365 0.0000000 0.0001977 ENSG00000114200 BCHE protein_coding -1.8140288
DRIMSeq ENST00000540653 0.0140365 0.0000000 0.0001977 ENSG00000114200 BCHE protein_coding 1.8140288
DRIMSeq ENST00000409400 0.0078481 0.0009747 0.0000136 ENSG00000136717 BIN1 protein_coding -1.2746670
DRIMSeq ENST00000423798 0.0391529 0.0117334 0.0002455 ENSG00000137274 BPHL protein_coding 1.7326422
DRIMSeq ENST00000583624 0.0186052 0.0129380 0.0002707 ENSG00000005379 BZRAP1 retained_intron 0.7665831
DRIMSeq ENST00000533472 0.0212969 0.0019594 0.0000820 ENSG00000182993 C12orf60 processed_transcript 1.0125358
DRIMSeq ENST00000342683 0.0170550 0.0028686 0.0001200 ENSG00000189227 C15orf61 protein_coding 1.1658347
DRIMSeq ENST00000338401 0.0017975 0.0000622 0.0000026 ENSG00000130731 C16orf13 protein_coding 1.2247350
DRIMSeq ENST00000397666 0.0017975 0.0299636 0.0012539 ENSG00000130731 C16orf13 protein_coding -0.8010465
DRIMSeq ENST00000459925 0.0470082 0.0000000 0.0018435 ENSG00000159761 C16orf86 retained_intron 1.5924318
DRIMSeq ENST00000403458 0.0470082 0.0000000 0.0018435 ENSG00000159761 C16orf86 protein_coding -1.5924318
DRIMSeq ENST00000565112 0.0372295 0.0075303 0.0003151 ENSG00000155330 C16orf87 protein_coding 1.0567511
DRIMSeq ENST00000588730 0.0286343 0.0017239 0.0000361 ENSG00000152242 C18orf25 protein_coding -1.6718541
DRIMSeq ENST00000294360 0.0008174 0.0000015 0.0000000 ENSG00000162384 C1orf123 protein_coding -1.0364800
DRIMSeq ENST00000493514 0.0010311 0.0000110 0.0000002 ENSG00000162642 C1orf52 processed_transcript -3.6963932
DRIMSeq ENST00000243189 0.0162533 0.0456796 0.0006372 ENSG00000117616 C1orf63 protein_coding 1.1304880
DRIMSeq ENST00000419612 0.0114729 0.0011603 0.0000243 ENSG00000197183 C20orf112 protein_coding 1.0574955
DRIMSeq ENST00000436325 0.0486374 0.0362970 0.0015189 ENSG00000188315 C3orf62 protein_coding 1.1134020
DRIMSeq ENST00000300900 0.0108473 0.0018686 0.0000261 ENSG00000167434 CA4 protein_coding -1.0491591
DRIMSeq ENST00000277549 0.0257168 0.0007590 0.0000079 ENSG00000148408 CACNA1B protein_coding -0.8841895
DRIMSeq ENST00000539935 0.0319243 0.0160198 0.0002235 ENSG00000182389 CACNB4 protein_coding -0.6497330
DRIMSeq ENST00000383710 0.0006675 0.0334416 0.0004665 ENSG00000163618 CADPS protein_coding -0.6596552
DRIMSeq ENST00000462768 0.0006675 0.0359395 0.0005013 ENSG00000163618 CADPS processed_transcript 0.8965756
DRIMSeq ENST00000550804 0.0006603 0.0000013 0.0000000 ENSG00000012822 CALCOCO1 protein_coding -0.9453936
DRIMSeq ENST00000333868 0.0407671 0.0209520 0.0004384 ENSG00000132906 CASP9 protein_coding -0.9396896
DRIMSeq ENST00000562719 0.0328170 0.0492656 0.0010308 ENSG00000129993 CBFA2T3 protein_coding 1.4338801
DRIMSeq ENST00000464832 0.0042411 0.0000162 0.0000002 ENSG00000128596 CCDC136 protein_coding -0.9917716
DRIMSeq ENST00000588821 0.0010311 0.0000379 0.0000008 ENSG00000183401 CCDC159 retained_intron 2.3549713
DRIMSeq ENST00000538586 0.0454731 0.0188191 0.0002625 ENSG00000123106 CCDC91 protein_coding 0.8028450
DRIMSeq ENST00000300415 0.0373939 0.0000000 0.0011541 ENSG00000101331 CCM2L protein_coding 2.2650169
DRIMSeq ENST00000452892 0.0373939 0.0000000 0.0011541 ENSG00000101331 CCM2L protein_coding -2.2650169
DRIMSeq ENST00000513102 0.0131100 0.0011948 0.0000500 ENSG00000134057 CCNB1 retained_intron 1.9251654
DRIMSeq ENST00000305596 0.0287317 0.0000000 0.0007519 ENSG00000169217 CD2BP2 protein_coding 1.1378188
DRIMSeq ENST00000569466 0.0287317 0.0000000 0.0007519 ENSG00000169217 CD2BP2 protein_coding -1.1378188
DRIMSeq ENST00000367041 0.0153421 0.0016072 0.0000336 ENSG00000117335 CD46 protein_coding -1.2505353
DRIMSeq ENST00000476153 0.0495117 0.0300290 0.0006283 ENSG00000117266 CDK18 retained_intron 1.0544479
DRIMSeq ENST00000346416 0.0099566 0.0008745 0.0000183 ENSG00000101391 CDK5RAP1 protein_coding -0.9271653
DRIMSeq ENST00000399837 0.0283962 0.0168402 0.0007047 ENSG00000093072 CECR1 protein_coding -1.9283406
DRIMSeq ENST00000514507 0.0068260 0.0002572 0.0000108 ENSG00000112877 CEP72 processed_transcript 1.0873366
DRIMSeq ENST00000262450 0.0039202 0.0000000 0.0000241 ENSG00000116254 CHD5 protein_coding 1.4686656
DRIMSeq ENST00000378021 0.0039202 0.0000000 0.0000241 ENSG00000116254 CHD5 protein_coding -1.4686656
DRIMSeq ENST00000255409 0.0168681 0.0010098 0.0000423 ENSG00000133048 CHI3L1 protein_coding -1.0521000
DRIMSeq ENST00000472064 0.0168681 0.0416564 0.0017432 ENSG00000133048 CHI3L1 retained_intron 1.0780159
DRIMSeq ENST00000325167 0.0036548 0.0000817 0.0000034 ENSG00000176108 CHMP6 protein_coding -1.3945507
DRIMSeq ENST00000258930 0.0328170 0.0000000 0.0009530 ENSG00000136425 CIB2 protein_coding -1.6091430
DRIMSeq ENST00000560618 0.0328170 0.0000000 0.0009530 ENSG00000136425 CIB2 protein_coding 1.6091430
DRIMSeq ENST00000424691 0.0456265 0.0037102 0.0000776 ENSG00000186162 CIDECP processed_transcript -0.8296886
DRIMSeq ENST00000216756 0.0031937 0.0001535 0.0000064 ENSG00000100865 CINP protein_coding -1.0206448
DRIMSeq ENST00000296951 0.0098169 0.0000000 0.0001010 ENSG00000113282 CLINT1 protein_coding 1.8890660
DRIMSeq ENST00000411809 0.0098169 0.0000000 0.0001010 ENSG00000113282 CLINT1 protein_coding -1.8890660
DRIMSeq ENST00000568865 0.0471741 0.0107545 0.0004500 ENSG00000064666 CNN2 protein_coding -1.6092766
DRIMSeq ENST00000517876 0.0257168 0.0000000 0.0006206 ENSG00000155508 CNOT8 protein_coding 1.0590803
DRIMSeq ENST00000285896 0.0257168 0.0000000 0.0006206 ENSG00000155508 CNOT8 protein_coding -1.0590803
DRIMSeq ENST00000548013 0.0391529 0.0085603 0.0001194 ENSG00000257727 CNPY2 retained_intron -0.7921687
DRIMSeq ENST00000459895 0.0071631 0.0212707 0.0004451 ENSG00000182871 COL18A1 processed_transcript -1.7248831
DRIMSeq ENST00000462604 0.0000001 0.0000000 0.0000000 ENSG00000144810 COL8A1 processed_transcript 8.3837880
DRIMSeq ENST00000444869 0.0196447 0.0071465 0.0001495 ENSG00000148444 COMMD3 protein_coding 2.5495677
DRIMSeq ENST00000267935 0.0011638 0.0004655 0.0000049 ENSG00000140365 COMMD4 protein_coding -1.1523673
DRIMSeq ENST00000567935 0.0011638 0.0358820 0.0003754 ENSG00000140365 COMMD4 retained_intron 0.9626023
DRIMSeq ENST00000249923 0.0398942 0.0000000 0.0013609 ENSG00000129083 COPB1 protein_coding 0.8482051
DRIMSeq ENST00000439561 0.0398942 0.0000000 0.0013609 ENSG00000129083 COPB1 protein_coding -0.8482051
DRIMSeq ENST00000251166 0.0313144 0.0047380 0.0001983 ENSG00000262246 CORO7 protein_coding -1.0169368
DRIMSeq ENST00000377049 0.0415266 0.0000000 0.0014864 ENSG00000241563 CORT protein_coding 1.7654900
DRIMSeq ENST00000320498 0.0415266 0.0000000 0.0014864 ENSG00000241563 CORT protein_coding -1.7654900
DRIMSeq ENST00000299335 0.0291518 0.0073175 0.0001531 ENSG00000166260 COX11 protein_coding -0.7270948
DRIMSeq ENST00000382395 0.0183958 0.0011899 0.0000249 ENSG00000137449 CPEB2 protein_coding -0.8246696
DRIMSeq ENST00000414664 0.0248575 0.0365076 0.0007639 ENSG00000214078 CPNE1 protein_coding -0.7967470
DRIMSeq ENST00000493411 0.0398035 0.0000000 0.0013418 ENSG00000124772 CPNE5 processed_transcript 0.9949214
DRIMSeq ENST00000244751 0.0398035 0.0000000 0.0013418 ENSG00000124772 CPNE5 protein_coding -0.9949214
DRIMSeq ENST00000435064 0.0406755 0.0075934 0.0003178 ENSG00000127054 CPSF3L protein_coding -0.8056608
DRIMSeq ENST00000332896 0.0188736 0.0038930 0.0000543 ENSG00000169372 CRADD protein_coding -1.1599359
DRIMSeq ENST00000452070 0.0036548 0.0330428 0.0004609 ENSG00000163703 CRELD1 protein_coding -1.2337124
DRIMSeq ENST00000589066 0.0143661 0.0000000 0.0002100 ENSG00000267011 CTB-50L17.16 lincRNA -2.0711939
DRIMSeq ENST00000591414 0.0143661 0.0000000 0.0002100 ENSG00000267011 CTB-50L17.16 lincRNA 2.0711939
DRIMSeq ENST00000412431 0.0475025 0.0000000 0.0019101 ENSG00000230551 CTB-89H12.4 processed_transcript -1.7884104
DRIMSeq ENST00000499521 0.0475025 0.0000000 0.0019101 ENSG00000230551 CTB-89H12.4 retained_intron 1.7884104
DRIMSeq ENST00000415461 0.0093571 0.0004165 0.0000174 ENSG00000085733 CTTN protein_coding 1.1090384
DRIMSeq ENST00000478630 0.0329283 0.0054399 0.0002276 ENSG00000044090 CUL7 processed_transcript 1.1090923
DRIMSeq ENST00000490926 0.0169822 0.0068615 0.0002871 ENSG00000114395 CYB561D2 processed_transcript 1.4042158
DRIMSeq ENST00000252945 0.0437751 0.0445079 0.0009313 ENSG00000130649 CYP2E1 protein_coding -1.2988260
DRIMSeq ENST00000368336 0.0036630 0.0000000 0.0000221 ENSG00000132676 DAP3 protein_coding -2.0827624
DRIMSeq ENST00000491777 0.0036630 0.0000000 0.0000221 ENSG00000132676 DAP3 protein_coding 2.0827624
DRIMSeq ENST00000301264 0.0226004 0.0043572 0.0001823 ENSG00000167657 DAPK3 protein_coding -0.7744343
DRIMSeq ENST00000233078 0.0049043 0.0001506 0.0000021 ENSG00000071626 DAZAP1 protein_coding -1.0834022
DRIMSeq ENST00000471767 0.0125518 0.0008924 0.0000373 ENSG00000113758 DBN1 retained_intron 1.3438272
DRIMSeq ENST00000220764 0.0002283 0.0000013 0.0000001 ENSG00000104325 DECR1 protein_coding -1.3752789
DRIMSeq ENST00000521668 0.0002283 0.0042333 0.0001772 ENSG00000104325 DECR1 processed_transcript 1.2559800
DRIMSeq ENST00000537639 0.0001595 0.0000005 0.0000000 ENSG00000146966 DENND2A protein_coding -3.3281245
DRIMSeq ENST00000485359 0.0111878 0.0029746 0.0001245 ENSG00000198837 DENND4B retained_intron 1.0039172
DRIMSeq ENST00000559656 0.0162533 0.0061220 0.0001281 ENSG00000140543 DET1 processed_transcript 2.4857970
DRIMSeq ENST00000409775 0.0000646 0.0000001 0.0000000 ENSG00000105928 DFNA5 protein_coding -1.7267904
DRIMSeq ENST00000331444 0.0098938 0.0005608 0.0000078 ENSG00000183628 DGCR6 protein_coding -1.1725661
DRIMSeq ENST00000497151 0.0077076 0.0020062 0.0000210 ENSG00000102796 DHRS12 processed_transcript 1.3640151
DRIMSeq ENST00000437541 0.0061001 0.0001099 0.0000023 ENSG00000231764 DLX6-AS1 antisense 1.7689443
DRIMSeq ENST00000592152 0.0078481 0.0036805 0.0000513 ENSG00000187775 DNAH17 processed_transcript -1.7930853
DRIMSeq ENST00000473051 0.0248575 0.0203178 0.0004251 ENSG00000148719 DNAJB12 retained_intron 0.9263625
DRIMSeq ENST00000379263 0.0169973 0.0473923 0.0004958 ENSG00000105821 DNAJC2 protein_coding -0.6414625
DRIMSeq ENST00000463668 0.0440348 0.0084165 0.0003522 ENSG00000142197 DOPEY2 retained_intron 0.7423597
DRIMSeq ENST00000561411 0.0003707 0.0051592 0.0000720 ENSG00000134146 DPH6 protein_coding -1.7862415
DRIMSeq ENST00000559585 0.0003707 0.0195683 0.0002730 ENSG00000134146 DPH6 processed_transcript -1.2947856
DRIMSeq ENST00000314392 0.0408566 0.0347709 0.0014551 ENSG00000136908 DPM2 protein_coding -0.8318632
DRIMSeq ENST00000360510 0.0066714 0.0001228 0.0000017 ENSG00000254986 DPP3 protein_coding -2.4786956
DRIMSeq ENST00000561350 0.0000060 0.0000000 0.0000000 ENSG00000128951 DUT processed_transcript 1.6823046
DRIMSeq ENST00000558813 0.0000060 0.0002405 0.0000101 ENSG00000128951 DUT protein_coding -0.8812886
DRIMSeq ENST00000379378 0.0378375 0.0067078 0.0002807 ENSG00000205250 E2F4 protein_coding -0.8668229
DRIMSeq ENST00000610011 0.0486374 0.0072775 0.0003045 ENSG00000249786 EAF1-AS1 antisense 2.7866400
DRIMSeq ENST00000342725 0.0000133 0.0000000 0.0000000 ENSG00000088881 EBF4 protein_coding -2.9289960
DRIMSeq ENST00000415912 0.0398035 0.0000000 0.0013495 ENSG00000117298 ECE1 protein_coding -1.1233416
DRIMSeq ENST00000470394 0.0398035 0.0000000 0.0013495 ENSG00000117298 ECE1 retained_intron 1.1233416
DRIMSeq ENST00000562238 0.0029802 0.0301363 0.0006306 ENSG00000167969 ECI1 protein_coding -0.9019361
DRIMSeq ENST00000565326 0.0221559 0.0019507 0.0000408 ENSG00000197774 EME2 retained_intron 2.4087661
DRIMSeq ENST00000562277 0.0066668 0.0001557 0.0000065 ENSG00000196678 ERI2 processed_transcript 3.9304830
DRIMSeq ENST00000468103 0.0019586 0.0000445 0.0000009 ENSG00000158220 ESYT3 retained_intron 0.9048475
DRIMSeq ENST00000306376 0.0348861 0.0000000 0.0010389 ENSG00000244405 ETV5 protein_coding -1.1139139
DRIMSeq ENST00000475484 0.0348861 0.0000000 0.0010389 ENSG00000244405 ETV5 retained_intron 1.1139139
DRIMSeq ENST00000512944 0.0392781 0.0000000 0.0012973 ENSG00000180104 EXOC3 protein_coding -2.1749415
DRIMSeq ENST00000315013 0.0392781 0.0000000 0.0012973 ENSG00000180104 EXOC3 protein_coding 2.1749415
DRIMSeq ENST00000374280 0.0026086 0.0000425 0.0000018 ENSG00000158008 EXTL1 protein_coding -1.0683296
DRIMSeq ENST00000470037 0.0026086 0.0026405 0.0001105 ENSG00000158008 EXTL1 processed_transcript 1.0021763
DRIMSeq ENST00000428826 0.0271797 0.0069012 0.0002888 ENSG00000108799 EZH1 protein_coding -0.7911486
DRIMSeq ENST00000586714 0.0271797 0.0343695 0.0014383 ENSG00000108799 EZH1 retained_intron 0.8162796
DRIMSeq ENST00000469631 0.0416977 0.0000000 0.0015088 ENSG00000106462 EZH2 retained_intron 1.4374563
DRIMSeq ENST00000483012 0.0416977 0.0000000 0.0015088 ENSG00000106462 EZH2 nonsense_mediated_decay -1.4374563
DRIMSeq ENST00000494172 0.0162533 0.0034118 0.0001428 ENSG00000168754 FAM178B retained_intron 1.8175405
DRIMSeq ENST00000520074 0.0162533 0.0499345 0.0020896 ENSG00000168754 FAM178B processed_transcript -1.3328915
DRIMSeq ENST00000491999 0.0272974 0.0061334 0.0002567 ENSG00000172366 FAM195A nonsense_mediated_decay -0.9111268
DRIMSeq ENST00000378557 0.0078481 0.0005022 0.0000070 ENSG00000005238 FAM214B protein_coding 3.4570075
DRIMSeq ENST00000548869 0.0384582 0.0212725 0.0004451 ENSG00000204856 FAM216A retained_intron 1.3419722
DRIMSeq ENST00000252530 0.0120253 0.0019652 0.0000274 ENSG00000130244 FAM98C protein_coding -1.2970493
DRIMSeq ENST00000467237 0.0398035 0.0425969 0.0008913 ENSG00000164896 FASTK retained_intron 0.9241629
DRIMSeq ENST00000289902 0.0169973 0.0019032 0.0000796 ENSG00000158869 FCER1G protein_coding -1.5696622
DRIMSeq ENST00000595713 0.0271797 0.0000000 0.0006749 ENSG00000090920 FCGBP processed_transcript 1.5920778
DRIMSeq ENST00000221347 0.0271797 0.0000000 0.0006749 ENSG00000090920 FCGBP protein_coding -1.5920778
DRIMSeq ENST00000345728 0.0398035 0.0157428 0.0001318 ENSG00000149781 FERMT3 protein_coding -1.4843458
DRIMSeq ENST00000586042 0.0195353 0.0019929 0.0000834 ENSG00000070388 FGF22 protein_coding -1.8427072
DRIMSeq ENST00000380991 0.0463093 0.0000000 0.0017997 ENSG00000119782 FKBP1B protein_coding 0.9043200
DRIMSeq ENST00000380986 0.0463093 0.0000000 0.0017997 ENSG00000119782 FKBP1B protein_coding -0.9043200
DRIMSeq ENST00000463443 0.0039202 0.0224129 0.0003126 ENSG00000122642 FKBP9 processed_transcript 1.1281675
DRIMSeq ENST00000330753 0.0098454 0.0001919 0.0000040 ENSG00000185070 FLRT2 protein_coding -0.7734551
DRIMSeq ENST00000570759 0.0138555 0.0005093 0.0000107 ENSG00000059122 FLYWCH1 processed_transcript 0.8153756
DRIMSeq ENST00000263578 0.0068715 0.0003491 0.0000073 ENSG00000110074 FOXRED1 protein_coding -1.1161403
DRIMSeq ENST00000479318 0.0000133 0.0000069 0.0000001 ENSG00000149531 FRG1B nonsense_mediated_decay 1.1325671
DRIMSeq ENST00000358464 0.0000133 0.0120715 0.0001684 ENSG00000149531 FRG1B protein_coding -0.7919398
DRIMSeq ENST00000439954 0.0000133 0.0365632 0.0005100 ENSG00000149531 FRG1B protein_coding -0.7661920
DRIMSeq ENST00000491130 0.0398035 0.0000000 0.0013437 ENSG00000170324 FRMPD2 retained_intron -2.9726224
DRIMSeq ENST00000486151 0.0398035 0.0000000 0.0013437 ENSG00000170324 FRMPD2 retained_intron 2.9726224
DRIMSeq ENST00000480823 0.0276992 0.0041309 0.0000864 ENSG00000163430 FSTL1 protein_coding -1.4761821
DRIMSeq ENST00000472006 0.0242750 0.0155143 0.0006492 ENSG00000107164 FUBP3 processed_transcript 0.9753220
DRIMSeq ENST00000349752 0.0471741 0.0389492 0.0005433 ENSG00000158089 GALNT14 protein_coding -1.3891135
DRIMSeq ENST00000389266 0.0287317 0.0000000 0.0007504 ENSG00000106105 GARS protein_coding -0.9835145
DRIMSeq ENST00000496643 0.0287317 0.0000000 0.0007504 ENSG00000106105 GARS retained_intron 0.9835145
DRIMSeq ENST00000268699 0.0458349 0.0219996 0.0004603 ENSG00000141013 GAS8 protein_coding -0.9257144
DRIMSeq ENST00000445230 0.0108017 0.0012498 0.0000523 ENSG00000239521 GATS processed_transcript 0.9204799
DRIMSeq ENST00000543273 0.0108017 0.0350759 0.0014678 ENSG00000239521 GATS processed_transcript -0.7630822
DRIMSeq ENST00000551549 0.0272974 0.0031164 0.0001304 ENSG00000089154 GCN1L1 retained_intron 0.7496507
DRIMSeq ENST00000591809 0.0498511 0.0096053 0.0004020 ENSG00000179168 GGN processed_transcript 1.6490569
DRIMSeq ENST00000487388 0.0328170 0.0000000 0.0009498 ENSG00000106560 GIMAP2 retained_intron 1.0594073
DRIMSeq ENST00000223293 0.0328170 0.0000000 0.0009498 ENSG00000106560 GIMAP2 protein_coding -1.0594073
DRIMSeq ENST00000413616 0.0263282 0.0000000 0.0006414 ENSG00000229894 GK3P processed_pseudogene -1.7180500
DRIMSeq ENST00000505354 0.0263282 0.0000000 0.0006414 ENSG00000229894 GK3P processed_pseudogene 1.7180500
DRIMSeq ENST00000377960 0.0095436 0.0008566 0.0000358 ENSG00000122694 GLIPR2 protein_coding -1.8208326
DRIMSeq ENST00000450791 0.0427593 0.0099006 0.0002072 ENSG00000090615 GOLGA3 protein_coding -0.6336461
DRIMSeq ENST00000264039 0.0221559 0.0000000 0.0004593 ENSG00000063660 GPC1 protein_coding -0.6498567
DRIMSeq ENST00000426280 0.0221559 0.0000000 0.0004593 ENSG00000063660 GPC1 protein_coding 0.6498567
DRIMSeq ENST00000397088 0.0456265 0.0039597 0.0000829 ENSG00000164850 GPER1 protein_coding -1.1971096
DRIMSeq ENST00000264126 0.0114729 0.0013986 0.0000293 ENSG00000121957 GPSM2 protein_coding -1.0249464
DRIMSeq ENST00000262895 0.0390499 0.0129424 0.0005416 ENSG00000105737 GRIK5 protein_coding -0.9642173
DRIMSeq ENST00000370963 0.0440348 0.0279542 0.0011698 ENSG00000170899 GSTA4 protein_coding -0.8130303
DRIMSeq ENST00000394730 0.0215993 0.0217317 0.0004547 ENSG00000138780 GSTCD protein_coding 1.9446981
DRIMSeq ENST00000515279 0.0215993 0.0280728 0.0005874 ENSG00000138780 GSTCD protein_coding -1.0478814
DRIMSeq ENST00000358406 0.0074888 0.0097645 0.0001362 ENSG00000197448 GSTK1 protein_coding -0.5488367
DRIMSeq ENST00000262903 0.0120253 0.0002114 0.0000029 ENSG00000085382 HACE1 protein_coding -1.1461413
DRIMSeq ENST00000206474 0.0232151 0.0276067 0.0001925 ENSG00000092036 HAUS4 protein_coding -2.2367704
DRIMSeq ENST00000498366 0.0232151 0.0124280 0.0002600 ENSG00000100429 HDAC10 processed_transcript -1.8389932
DRIMSeq ENST00000305264 0.0010624 0.0000064 0.0000001 ENSG00000171720 HDAC3 protein_coding -1.3820177
DRIMSeq ENST00000504994 0.0329283 0.0048199 0.0002017 ENSG00000138641 HERC3 processed_transcript 0.9366559
DRIMSeq ENST00000506842 0.0025089 0.0002613 0.0000055 ENSG00000138642 HERC6 retained_intron 1.1438326
DRIMSeq ENST00000264346 0.0025089 0.0007131 0.0000149 ENSG00000138642 HERC6 protein_coding -0.8447323
DRIMSeq ENST00000414928 0.0159208 0.0020979 0.0000878 ENSG00000198130 HIBCH nonsense_mediated_decay 1.5829753
DRIMSeq ENST00000377777 0.0220696 0.0000000 0.0004522 ENSG00000158373 HIST1H2BD protein_coding -0.9484472
DRIMSeq ENST00000289316 0.0220696 0.0000000 0.0004522 ENSG00000158373 HIST1H2BD protein_coding 0.9484472
DRIMSeq ENST00000278715 0.0302169 0.0146899 0.0006147 ENSG00000256269 HMBS protein_coding -2.2032844
DRIMSeq ENST00000374490 0.0036200 0.0001174 0.0000016 ENSG00000117305 HMGCL protein_coding -1.1073140
DRIMSeq ENST00000450735 0.0151744 0.0182778 0.0002550 ENSG00000103942 HOMER2 protein_coding -0.6645634
DRIMSeq ENST00000312239 0.0000716 0.0044433 0.0000620 ENSG00000127483 HP1BP3 protein_coding -0.7854513
DRIMSeq ENST00000508413 0.0007032 0.0000171 0.0000007 ENSG00000198189 HSD17B11 processed_transcript 1.8819957
DRIMSeq ENST00000358290 0.0007032 0.0023451 0.0000981 ENSG00000198189 HSD17B11 protein_coding -1.0319406
DRIMSeq ENST00000554643 0.0250609 0.0409762 0.0008574 ENSG00000025423 HSD17B6 protein_coding 1.7116236
DRIMSeq ENST00000380405 0.0014299 0.0001807 0.0000076 ENSG00000120694 HSPH1 protein_coding 1.9972896
DRIMSeq ENST00000320027 0.0014299 0.0002259 0.0000095 ENSG00000120694 HSPH1 protein_coding -1.5100934
DRIMSeq ENST00000438323 0.0098938 0.0024063 0.0000503 ENSG00000068079 IFI35 protein_coding -1.8035612
DRIMSeq ENST00000549628 0.0249355 0.0015050 0.0000315 ENSG00000167779 IGFBP6 processed_transcript 2.2795989
DRIMSeq ENST00000519735 0.0313144 0.0127904 0.0005352 ENSG00000104365 IKBKB protein_coding -0.8395687
DRIMSeq ENST00000589173 0.0114150 0.0054709 0.0002289 ENSG00000129351 ILF3 retained_intron 0.7791584
DRIMSeq ENST00000256108 0.0169973 0.0000000 0.0002969 ENSG00000133731 IMPA1 protein_coding -1.0263682
DRIMSeq ENST00000522997 0.0169973 0.0000000 0.0002969 ENSG00000133731 IMPA1 protein_coding 1.0263682
DRIMSeq ENST00000326739 0.0241927 0.0032665 0.0001367 ENSG00000178035 IMPDH2 protein_coding -0.8081971
DRIMSeq ENST00000243786 0.0397215 0.0000000 0.0013212 ENSG00000123999 INHA protein_coding -1.6758153
DRIMSeq ENST00000489456 0.0397215 0.0000000 0.0013212 ENSG00000123999 INHA processed_transcript 1.6758153
DRIMSeq ENST00000498104 0.0388082 0.0319763 0.0006691 ENSG00000173226 IQCB1 protein_coding 1.0429110
DRIMSeq ENST00000228799 0.0281745 0.0000000 0.0007199 ENSG00000111203 ITFG2 protein_coding -1.0595920
DRIMSeq ENST00000552005 0.0281745 0.0000000 0.0007199 ENSG00000111203 ITFG2 processed_transcript 1.0595920
DRIMSeq ENST00000356798 0.0416977 0.0000000 0.0015095 ENSG00000005844 ITGAL protein_coding -1.4890878
DRIMSeq ENST00000562020 0.0416977 0.0000000 0.0015095 ENSG00000005844 ITGAL retained_intron 1.4890878
DRIMSeq ENST00000397146 0.0036630 0.0442328 0.0006170 ENSG00000123243 ITIH5 protein_coding -1.6642891
DRIMSeq ENST00000366758 0.0415266 0.0076802 0.0003214 ENSG00000081692 JMJD4 protein_coding -1.5606634
DRIMSeq ENST00000397299 0.0181827 0.0014837 0.0000621 ENSG00000243789 JMJD7 protein_coding -1.2706256
DRIMSeq ENST00000240662 0.0398035 0.0000000 0.0013400 ENSG00000121361 KCNJ8 protein_coding -1.9991853
DRIMSeq ENST00000537950 0.0398035 0.0000000 0.0013400 ENSG00000121361 KCNJ8 protein_coding 1.9991853
DRIMSeq ENST00000472869 0.0139758 0.0018995 0.0000795 ENSG00000135750 KCNK1 processed_transcript 1.0871946
DRIMSeq ENST00000357249 0.0192964 0.0000000 0.0003582 ENSG00000075043 KCNQ2 protein_coding -0.9664944
DRIMSeq ENST00000482957 0.0192964 0.0000000 0.0003582 ENSG00000075043 KCNQ2 processed_transcript 0.9664944
DRIMSeq ENST00000298480 0.0215033 0.0008593 0.0000120 ENSG00000107147 KCNT1 protein_coding -1.2598015
DRIMSeq ENST00000470573 0.0169973 0.0009326 0.0000195 ENSG00000117139 KDM5B processed_transcript 0.9920578
DRIMSeq ENST00000484801 0.0494148 0.0117981 0.0004937 ENSG00000135314 KHDC1 processed_transcript 0.8777868
DRIMSeq ENST00000327300 0.0206276 0.0000000 0.0003973 ENSG00000121774 KHDRBS1 protein_coding -0.8538406
DRIMSeq ENST00000484270 0.0206276 0.0000000 0.0003973 ENSG00000121774 KHDRBS1 processed_transcript 0.8538406
DRIMSeq ENST00000425103 0.0463093 0.0070284 0.0002941 ENSG00000170871 KIAA0232 protein_coding -0.8978934
DRIMSeq ENST00000443149 0.0058570 0.0212210 0.0002960 ENSG00000183354 KIAA2026 processed_transcript 0.9813160
DRIMSeq ENST00000534023 0.0002283 0.0000173 0.0000004 ENSG00000174996 KLC2 retained_intron 1.5564606
DRIMSeq ENST00000347162 0.0120253 0.0000000 0.0001537 ENSG00000137171 KLC4 protein_coding -1.0187363
DRIMSeq ENST00000463168 0.0120253 0.0000000 0.0001537 ENSG00000137171 KLC4 retained_intron 1.0187363
DRIMSeq ENST00000554589 0.0319243 0.0054493 0.0001140 ENSG00000165516 KLHDC2 protein_coding -1.3062247
DRIMSeq ENST00000328879 0.0237692 0.0014938 0.0000313 ENSG00000099910 KLHL22 protein_coding -0.7030909
DRIMSeq ENST00000392647 0.0178093 0.0000000 0.0003152 ENSG00000213160 KLHL23 protein_coding 1.1899031
DRIMSeq ENST00000437875 0.0178093 0.0000000 0.0003152 ENSG00000213160 KLHL23 protein_coding -1.1899031
DRIMSeq ENST00000344442 0.0398035 0.0000000 0.0013394 ENSG00000174720 LARP7 protein_coding 0.8310427
DRIMSeq ENST00000324052 0.0398035 0.0000000 0.0013394 ENSG00000174720 LARP7 protein_coding -0.8310427
DRIMSeq ENST00000334869 0.0154020 0.0012476 0.0000522 ENSG00000100600 LGMN protein_coding -1.1501401
DRIMSeq ENST00000396595 0.0313642 0.0082521 0.0003453 ENSG00000064042 LIMCH1 protein_coding -0.8440741
DRIMSeq ENST00000221459 0.0078481 0.0000000 0.0000716 ENSG00000104863 LIN7B protein_coding -1.4942078
DRIMSeq ENST00000474252 0.0078481 0.0000000 0.0000716 ENSG00000104863 LIN7B retained_intron 1.4942078
DRIMSeq ENST00000510736 0.0168681 0.0058883 0.0001232 ENSG00000251372 LINC00499 lincRNA -1.1402876
DRIMSeq ENST00000502757 0.0168681 0.0093774 0.0001962 ENSG00000251372 LINC00499 lincRNA 0.9281199
DRIMSeq ENST00000555246 0.0452514 0.0000000 0.0016871 ENSG00000258700 LINC00871 lincRNA -1.1031793
DRIMSeq ENST00000556886 0.0452514 0.0000000 0.0016871 ENSG00000258700 LINC00871 lincRNA 1.1031793
DRIMSeq ENST00000429464 0.0133295 0.0011088 0.0000464 ENSG00000235597 LINC01102 lincRNA 1.1393503
DRIMSeq ENST00000449448 0.0125518 0.0099299 0.0001039 ENSG00000233723 LINC01122 lincRNA -2.8839416
DRIMSeq ENST00000262301 0.0187088 0.0026834 0.0000561 ENSG00000103227 LMF1 protein_coding -1.0928551
DRIMSeq ENST00000345941 0.0240234 0.0041130 0.0000574 ENSG00000139679 LPAR6 protein_coding -1.5231058
DRIMSeq ENST00000336356 0.0389363 0.0000000 0.0012619 ENSG00000121207 LRAT protein_coding -2.6677087
DRIMSeq ENST00000510733 0.0389363 0.0000000 0.0012619 ENSG00000121207 LRAT retained_intron 2.6677087
DRIMSeq ENST00000558799 0.0187451 0.0000000 0.0003436 ENSG00000137821 LRRC49 processed_transcript 1.1908249
DRIMSeq ENST00000260382 0.0187451 0.0000000 0.0003436 ENSG00000137821 LRRC49 protein_coding -1.1908249
DRIMSeq ENST00000397130 0.0169822 0.0018764 0.0000785 ENSG00000180979 LRRC57 protein_coding -1.1503256
DRIMSeq ENST00000323443 0.0169822 0.0106776 0.0004468 ENSG00000180979 LRRC57 protein_coding 1.2068703
DRIMSeq ENST00000440313 0.0471573 0.0054566 0.0000761 ENSG00000184154 LRTOMT protein_coding 1.4097454
DRIMSeq ENST00000396052 0.0406755 0.0040264 0.0000842 ENSG00000102897 LYRM1 protein_coding 0.9813317
DRIMSeq ENST00000478551 0.0241927 0.0030862 0.0001291 ENSG00000163818 LZTFL1 retained_intron 1.0888532
DRIMSeq ENST00000507385 0.0000716 0.0000003 0.0000000 ENSG00000161021 MAML1 retained_intron 2.1148540
DRIMSeq ENST00000292599 0.0000716 0.0254642 0.0005328 ENSG00000161021 MAML1 protein_coding -0.9514561
DRIMSeq ENST00000285599 0.0440348 0.0000000 0.0016202 ENSG00000013288 MAN2B2 protein_coding -0.8782643
DRIMSeq ENST00000505907 0.0440348 0.0000000 0.0016202 ENSG00000013288 MAN2B2 protein_coding 0.8782643
DRIMSeq ENST00000358935 0.0232151 0.0086004 0.0003599 ENSG00000198060 MARCH5 protein_coding -0.6771257
DRIMSeq ENST00000262027 0.0115249 0.0000000 0.0001416 ENSG00000166986 MARS protein_coding -1.0842761
DRIMSeq ENST00000548202 0.0115249 0.0000000 0.0001416 ENSG00000166986 MARS retained_intron 1.0842761
DRIMSeq ENST00000251472 0.0241681 0.0030528 0.0001278 ENSG00000105613 MAST1 protein_coding -0.7833693
DRIMSeq ENST00000310132 0.0407671 0.0259631 0.0005432 ENSG00000007264 MATK protein_coding 1.4769804
DRIMSeq ENST00000457839 0.0098454 0.0016106 0.0000674 ENSG00000141644 MBD1 protein_coding -0.8487705
DRIMSeq ENST00000586884 0.0098454 0.0241358 0.0010100 ENSG00000141644 MBD1 retained_intron 0.6725778
DRIMSeq ENST00000397865 0.0359426 0.0082221 0.0003441 ENSG00000197971 MBP protein_coding 0.9356743
DRIMSeq ENST00000263702 0.0099097 0.0006252 0.0000262 ENSG00000116353 MECR protein_coding -1.2668671
DRIMSeq ENST00000564661 0.0151134 0.0414936 0.0008682 ENSG00000103260 METRN retained_intron 0.8569623
DRIMSeq ENST00000301327 0.0207421 0.0025670 0.0001074 ENSG00000167700 MFSD3 protein_coding -0.9814941
DRIMSeq ENST00000296468 0.0248575 0.0000000 0.0005845 ENSG00000164073 MFSD8 protein_coding -1.0212083
DRIMSeq ENST00000503928 0.0248575 0.0000000 0.0005845 ENSG00000164073 MFSD8 processed_transcript 1.0212083
DRIMSeq ENST00000496253 0.0021572 0.0000275 0.0000011 ENSG00000135953 MFSD9 processed_transcript -3.6828703
DRIMSeq ENST00000333055 0.0386784 0.0046563 0.0000974 ENSG00000131446 MGAT1 protein_coding -1.0753636
DRIMSeq ENST00000341184 0.0248575 0.0026858 0.0001124 ENSG00000128268 MGAT3 protein_coding -0.7326571
DRIMSeq ENST00000597600 0.0445188 0.0000000 0.0016564 ENSG00000261857 MIA protein_coding -2.0785851
DRIMSeq ENST00000593317 0.0445188 0.0000000 0.0016564 ENSG00000261857 MIA retained_intron 2.0785851
DRIMSeq ENST00000290130 0.0250609 0.0000000 0.0005989 ENSG00000159055 MIS18A protein_coding -1.4702847
DRIMSeq ENST00000486363 0.0250609 0.0000000 0.0005989 ENSG00000159055 MIS18A processed_transcript 1.4702847
DRIMSeq ENST00000355630 0.0398035 0.0182712 0.0007646 ENSG00000196588 MKL1 protein_coding -0.6947315
DRIMSeq ENST00000591601 0.0001876 0.0000318 0.0000007 ENSG00000099875 MKNK2 protein_coding -1.3362476
DRIMSeq ENST00000309340 0.0001876 0.0001463 0.0000031 ENSG00000099875 MKNK2 protein_coding 1.4461172
DRIMSeq ENST00000566203 0.0386784 0.0063844 0.0002672 ENSG00000126005 MMP24-AS1 antisense 0.9106349
DRIMSeq ENST00000483013 0.0150745 0.0025381 0.0000354 ENSG00000204655 MOG protein_coding 2.1036125
DRIMSeq ENST00000376917 0.0150745 0.0407875 0.0005689 ENSG00000204655 MOG protein_coding -0.9537144
DRIMSeq ENST00000569021 0.0076054 0.0000000 0.0000653 ENSG00000135698 MPHOSPH6 protein_coding 0.9421147
DRIMSeq ENST00000258169 0.0076054 0.0000000 0.0000653 ENSG00000135698 MPHOSPH6 protein_coding -0.9421147
DRIMSeq ENST00000435114 0.0138555 0.0130005 0.0001813 ENSG00000115204 MPV17 protein_coding 1.8105675
DRIMSeq ENST00000380044 0.0138555 0.0164623 0.0002296 ENSG00000115204 MPV17 protein_coding -0.9580214
DRIMSeq ENST00000479638 0.0471741 0.0000000 0.0018864 ENSG00000112110 MRPL18 processed_transcript 0.8030617
DRIMSeq ENST00000367034 0.0471741 0.0000000 0.0018864 ENSG00000112110 MRPL18 protein_coding -0.8030617
DRIMSeq ENST00000418740 0.0459801 0.0000000 0.0017712 ENSG00000062582 MRPS24 nonsense_mediated_decay 0.6589720
DRIMSeq ENST00000317534 0.0459801 0.0000000 0.0017712 ENSG00000062582 MRPS24 protein_coding -0.6589720
DRIMSeq ENST00000609421 0.0388082 0.0068598 0.0002871 ENSG00000173171 MTX1 protein_coding -0.7560438
DRIMSeq ENST00000594784 0.0071631 0.0002766 0.0000039 ENSG00000141971 MVB12A protein_coding -2.6686215
DRIMSeq ENST00000398598 0.0097751 0.0004273 0.0000179 ENSG00000157601 MX1 protein_coding -0.9772560
DRIMSeq ENST00000484465 0.0097751 0.0072356 0.0003028 ENSG00000157601 MX1 retained_intron 0.8147220
DRIMSeq ENST00000409745 0.0142257 0.0000000 0.0002049 ENSG00000185105 MYADML2 protein_coding 2.4962177
DRIMSeq ENST00000330655 0.0142257 0.0000000 0.0002049 ENSG00000185105 MYADML2 protein_coding -2.4962177
DRIMSeq ENST00000303775 0.0212294 0.0069504 0.0002909 ENSG00000156239 N6AMT1 protein_coding -1.0417695
DRIMSeq ENST00000351429 0.0212294 0.0090333 0.0003780 ENSG00000156239 N6AMT1 protein_coding 1.1017655
DRIMSeq ENST00000342556 0.0104651 0.0011302 0.0000473 ENSG00000166886 NAB2 protein_coding 1.7373494
DRIMSeq ENST00000300131 0.0104651 0.0157505 0.0006591 ENSG00000166886 NAB2 protein_coding -1.3735670
DRIMSeq ENST00000341463 0.0456265 0.0085045 0.0003559 ENSG00000139579 NABP2 protein_coding -1.2160974
DRIMSeq ENST00000310701 0.0115249 0.0000000 0.0001417 ENSG00000122497 NBPF14 protein_coding 2.4292292
DRIMSeq ENST00000369219 0.0115249 0.0000000 0.0001417 ENSG00000122497 NBPF14 protein_coding -2.4292292
DRIMSeq ENST00000315579 0.0415266 0.0075328 0.0003152 ENSG00000010292 NCAPD2 protein_coding -1.1149720
DRIMSeq ENST00000420993 0.0050465 0.0002598 0.0000109 ENSG00000025770 NCAPH2 protein_coding -0.8220696
DRIMSeq ENST00000517331 0.0036062 0.0002331 0.0000098 ENSG00000104419 NDRG1 processed_transcript 1.4785722
DRIMSeq ENST00000323851 0.0036062 0.0410208 0.0017166 ENSG00000104419 NDRG1 protein_coding -0.6970293
DRIMSeq ENST00000268668 0.0381589 0.0000000 0.0011838 ENSG00000140990 NDUFB10 protein_coding -1.1272128
DRIMSeq ENST00000543683 0.0381589 0.0000000 0.0011838 ENSG00000140990 NDUFB10 protein_coding 1.1272128
DRIMSeq ENST00000392179 0.0066668 0.0012946 0.0000542 ENSG00000158864 NDUFS2 protein_coding 1.9491806
DRIMSeq ENST00000367993 0.0066668 0.0107253 0.0004488 ENSG00000158864 NDUFS2 protein_coding -1.1117745
DRIMSeq ENST00000375238 0.0150533 0.0016661 0.0000697 ENSG00000125967 NECAB3 protein_coding -1.2736157
DRIMSeq ENST00000436750 0.0078481 0.0000000 0.0000723 ENSG00000154328 NEIL2 protein_coding -0.9758516
DRIMSeq ENST00000284503 0.0078481 0.0000000 0.0000723 ENSG00000154328 NEIL2 protein_coding 0.9758516
DRIMSeq ENST00000233027 0.0475025 0.0294047 0.0012305 ENSG00000114904 NEK4 protein_coding -0.6494533
DRIMSeq ENST00000493199 0.0475025 0.0304847 0.0012757 ENSG00000114904 NEK4 retained_intron 0.6949319
DRIMSeq ENST00000404295 0.0312475 0.0035977 0.0000376 ENSG00000153406 NMRAL1 protein_coding -1.4254810
DRIMSeq ENST00000378165 0.0236176 0.0329240 0.0004593 ENSG00000152465 NMT2 protein_coding -0.5872966
DRIMSeq ENST00000496938 0.0236176 0.0024103 0.0000504 ENSG00000188976 NOC2L processed_transcript 1.7773365
DRIMSeq ENST00000362074 0.0077076 0.0067696 0.0001416 ENSG00000213240 NOTCH2NL protein_coding -1.3892162
DRIMSeq ENST00000468544 0.0232446 0.0060152 0.0002517 ENSG00000107833 NPM3 processed_transcript 2.9644529
DRIMSeq ENST00000425241 0.0115824 0.0013028 0.0000273 ENSG00000177463 NR2C2 protein_coding -0.9012020
DRIMSeq ENST00000352171 0.0215033 0.0000000 0.0004259 ENSG00000078618 NRD1 protein_coding -0.7807143
DRIMSeq ENST00000464385 0.0215033 0.0000000 0.0004259 ENSG00000078618 NRD1 processed_transcript 0.7807143
DRIMSeq ENST00000287437 0.0194115 0.0023848 0.0000499 ENSG00000156831 NSMCE2 protein_coding -1.0658239
DRIMSeq ENST00000252594 0.0005851 0.0003100 0.0000130 ENSG00000130305 NSUN5 protein_coding 2.1673125
DRIMSeq ENST00000438747 0.0005851 0.0003351 0.0000140 ENSG00000130305 NSUN5 protein_coding -1.6241298
DRIMSeq ENST00000562263 0.0196447 0.0138178 0.0005782 ENSG00000095906 NUBP2 protein_coding 1.7718911
DRIMSeq ENST00000279206 0.0496424 0.0140339 0.0001958 ENSG00000149761 NUDT22 protein_coding -0.7796945
DRIMSeq ENST00000552283 0.0249355 0.0000000 0.0005907 ENSG00000075188 NUP37 protein_coding -0.9763259
DRIMSeq ENST00000550459 0.0249355 0.0000000 0.0005907 ENSG00000075188 NUP37 protein_coding 0.9763259
DRIMSeq ENST00000462534 0.0114150 0.0270758 0.0005665 ENSG00000124006 OBSL1 retained_intron 0.8496862
DRIMSeq ENST00000374103 0.0414476 0.0000000 0.0014587 ENSG00000197444 OGDHL protein_coding -0.8005873
DRIMSeq ENST00000496884 0.0414476 0.0000000 0.0014587 ENSG00000197444 OGDHL processed_transcript 0.8005873
DRIMSeq ENST00000358603 0.0212161 0.0027399 0.0000573 ENSG00000162600 OMA1 protein_coding -2.0197874
DRIMSeq ENST00000338972 0.0396600 0.0311265 0.0013026 ENSG00000172239 PAIP1 protein_coding 1.1868890
DRIMSeq ENST00000455170 0.0304279 0.0162043 0.0006781 ENSG00000238197 PAXBP1-AS1 antisense -1.5482821
DRIMSeq ENST00000308824 0.0115249 0.0012746 0.0000267 ENSG00000203880 PCMTD2 protein_coding -0.7153863
DRIMSeq ENST00000355703 0.0359426 0.0000000 0.0010827 ENSG00000197136 PCNXL3 protein_coding -2.3042521
DRIMSeq ENST00000531045 0.0359426 0.0000000 0.0010827 ENSG00000197136 PCNXL3 processed_transcript 2.3042521
DRIMSeq ENST00000490749 0.0238427 0.0324560 0.0013582 ENSG00000186642 PDE2A retained_intron 0.8448294
DRIMSeq ENST00000334456 0.0238427 0.0350726 0.0014677 ENSG00000186642 PDE2A protein_coding -0.6481895
DRIMSeq ENST00000261799 0.0159637 0.0000000 0.0002544 ENSG00000113721 PDGFRB protein_coding -0.9589173
DRIMSeq ENST00000522466 0.0159637 0.0000000 0.0002544 ENSG00000113721 PDGFRB retained_intron 0.9589173
DRIMSeq ENST00000320740 0.0020177 0.0000887 0.0000037 ENSG00000174516 PELI3 protein_coding -1.4294002
DRIMSeq ENST00000528752 0.0020177 0.0431933 0.0018075 ENSG00000174516 PELI3 protein_coding 1.3820407
DRIMSeq ENST00000381125 0.0000060 0.0000000 0.0000000 ENSG00000067057 PFKP protein_coding -1.3319847
DRIMSeq ENST00000413079 0.0000060 0.0038419 0.0000804 ENSG00000067057 PFKP protein_coding 1.4105881
DRIMSeq ENST00000381072 0.0000060 0.0154356 0.0003230 ENSG00000067057 PFKP protein_coding 1.2092338
DRIMSeq ENST00000373418 0.0494148 0.0000000 0.0020327 ENSG00000134686 PHC2 protein_coding -0.7791115
DRIMSeq ENST00000473158 0.0494148 0.0000000 0.0020327 ENSG00000134686 PHC2 processed_transcript 0.7791115
DRIMSeq ENST00000263038 0.0475025 0.0000000 0.0019107 ENSG00000107537 PHYH protein_coding -1.0518197
DRIMSeq ENST00000396913 0.0475025 0.0000000 0.0019107 ENSG00000107537 PHYH protein_coding 1.0518197
DRIMSeq ENST00000356976 0.0162533 0.0011265 0.0000471 ENSG00000100151 PICK1 protein_coding -0.8216912
DRIMSeq ENST00000335312 0.0348237 0.0000000 0.0010344 ENSG00000186111 PIP5K1C protein_coding -0.9284241
DRIMSeq ENST00000592530 0.0348237 0.0000000 0.0010344 ENSG00000186111 PIP5K1C processed_transcript 0.9284241
DRIMSeq ENST00000415826 0.0495322 0.0174277 0.0003646 ENSG00000176485 PLA2G16 protein_coding -0.7533003
DRIMSeq ENST00000558505 0.0305121 0.0013332 0.0000139 ENSG00000137841 PLCB2 retained_intron 2.4198269
DRIMSeq ENST00000326631 0.0036062 0.0000432 0.0000009 ENSG00000104886 PLEKHJ1 protein_coding -0.8254397
DRIMSeq ENST00000246027 0.0280838 0.0086212 0.0003608 ENSG00000088970 PLK1S1 processed_transcript -0.8372696
DRIMSeq ENST00000441136 0.0280838 0.0150369 0.0006293 ENSG00000088970 PLK1S1 processed_transcript 0.9389383
DRIMSeq ENST00000282903 0.0002283 0.0000744 0.0000016 ENSG00000152952 PLOD2 protein_coding -1.3183890
DRIMSeq ENST00000360060 0.0002283 0.0001135 0.0000024 ENSG00000152952 PLOD2 protein_coding 1.1869520
DRIMSeq ENST00000383083 0.0005305 0.0000231 0.0000010 ENSG00000114698 PLSCR4 protein_coding 2.8372644
DRIMSeq ENST00000354952 0.0005305 0.0001952 0.0000082 ENSG00000114698 PLSCR4 protein_coding -1.5338732
DRIMSeq ENST00000368277 0.0337064 0.0048388 0.0002025 ENSG00000160783 PMF1 protein_coding -0.9042899
DRIMSeq ENST00000257694 0.0495117 0.0094672 0.0003962 ENSG00000135241 PNPLA8 protein_coding -0.8264476
DRIMSeq ENST00000601098 0.0080010 0.0089282 0.0001245 ENSG00000062822 POLD1 protein_coding -2.1238748
DRIMSeq ENST00000312419 0.0002283 0.0000004 0.0000000 ENSG00000175482 POLD4 protein_coding -1.3531897
DRIMSeq ENST00000441964 0.0099020 0.0000000 0.0001072 ENSG00000144647 POMGNT2 protein_coding -0.9882633
DRIMSeq ENST00000344697 0.0099020 0.0000000 0.0001072 ENSG00000144647 POMGNT2 protein_coding 0.9882633
DRIMSeq ENST00000455780 0.0092235 0.0002477 0.0000052 ENSG00000127125 PPCS protein_coding -1.3276938
DRIMSeq ENST00000263212 0.0291518 0.0000000 0.0007870 ENSG00000100034 PPM1F protein_coding -1.8458526
DRIMSeq ENST00000497072 0.0291518 0.0000000 0.0007870 ENSG00000100034 PPM1F processed_transcript 1.8458526
DRIMSeq ENST00000587515 0.0118089 0.0000000 0.0001480 ENSG00000167641 PPP1R14A protein_coding 1.3685234
DRIMSeq ENST00000301242 0.0118089 0.0000000 0.0001480 ENSG00000167641 PPP1R14A protein_coding -1.3685234
DRIMSeq ENST00000433473 0.0456265 0.0000000 0.0017491 ENSG00000131238 PPT1 protein_coding 1.0647880
DRIMSeq ENST00000529905 0.0456265 0.0000000 0.0017491 ENSG00000131238 PPT1 nonsense_mediated_decay -1.0647880
DRIMSeq ENST00000590895 0.0011704 0.0005744 0.0000120 ENSG00000122490 PQLC1 processed_transcript 1.1491573
DRIMSeq ENST00000397778 0.0011704 0.0300370 0.0006285 ENSG00000122490 PQLC1 protein_coding -0.6299372
DRIMSeq ENST00000375155 0.0314764 0.0142295 0.0005955 ENSG00000040487 PQLC2 protein_coding -0.8885630
DRIMSeq ENST00000547306 0.0196835 0.0017635 0.0000738 ENSG00000181929 PRKAG1 protein_coding -0.8260371
DRIMSeq ENST00000547125 0.0196835 0.0326367 0.0013658 ENSG00000181929 PRKAG1 protein_coding 0.6996628
DRIMSeq ENST00000592741 0.0207287 0.0148245 0.0002068 ENSG00000130175 PRKCSH protein_coding -0.7561416
DRIMSeq ENST00000382622 0.0077076 0.0015047 0.0000630 ENSG00000111218 PRMT8 protein_coding -1.1724152
DRIMSeq ENST00000452611 0.0077076 0.0023268 0.0000974 ENSG00000111218 PRMT8 protein_coding 1.3828282
DRIMSeq ENST00000334029 0.0388082 0.0032880 0.0000459 ENSG00000100033 PRODH protein_coding -1.4798192
DRIMSeq ENST00000337659 0.0296621 0.0133604 0.0002795 ENSG00000112739 PRPF4B protein_coding -0.8280113
DRIMSeq ENST00000324684 0.0388082 0.0021724 0.0000227 ENSG00000161542 PRPSAP1 protein_coding -0.8091046
DRIMSeq ENST00000375152 0.0114729 0.0051254 0.0002145 ENSG00000204314 PRRT1 protein_coding -1.6293289
DRIMSeq ENST00000591949 0.0398035 0.0064569 0.0002702 ENSG00000205155 PSENEN protein_coding 1.1716823
DRIMSeq ENST00000532358 0.0392027 0.0140341 0.0001958 ENSG00000230487 PSMG3-AS1 lincRNA 1.8498163
DRIMSeq ENST00000371625 0.0364431 0.0000000 0.0011050 ENSG00000107317 PTGDS protein_coding -1.4216030
DRIMSeq ENST00000467871 0.0364431 0.0000000 0.0011050 ENSG00000107317 PTGDS processed_transcript 1.4216030
DRIMSeq ENST00000497385 0.0319356 0.0050793 0.0002126 ENSG00000134247 PTGFRN processed_transcript 1.8693103
DRIMSeq ENST00000346049 0.0116080 0.0000000 0.0001446 ENSG00000120899 PTK2B protein_coding -1.1386662
DRIMSeq ENST00000521000 0.0116080 0.0000000 0.0001446 ENSG00000120899 PTK2B retained_intron 1.1386662
DRIMSeq ENST00000599732 0.0030661 0.0000547 0.0000023 ENSG00000104960 PTOV1 protein_coding -1.0554209
DRIMSeq ENST00000361574 0.0359426 0.0000000 0.0010810 ENSG00000198858 R3HDM4 protein_coding -1.0259227
DRIMSeq ENST00000590454 0.0359426 0.0000000 0.0010810 ENSG00000198858 R3HDM4 nonsense_mediated_decay 1.0259227
DRIMSeq ENST00000519348 0.0021685 0.0004886 0.0000102 ENSG00000197275 RAD54B processed_transcript 2.0624137
DRIMSeq ENST00000372047 0.0221380 0.0277857 0.0005814 ENSG00000160271 RALGDS protein_coding -1.1785559
DRIMSeq ENST00000522647 0.0493315 0.0091317 0.0001911 ENSG00000184672 RALYL protein_coding 1.0012023
DRIMSeq ENST00000296604 0.0143308 0.0067476 0.0002824 ENSG00000164188 RANBP3L protein_coding -0.6649506
DRIMSeq ENST00000515759 0.0143308 0.0078462 0.0003283 ENSG00000164188 RANBP3L protein_coding 0.9602182
DRIMSeq ENST00000430128 0.0265730 0.0043100 0.0001804 ENSG00000228016 RAPGEF4-AS1 antisense 1.7806003
DRIMSeq ENST00000493269 0.0236176 0.0067456 0.0001411 ENSG00000146282 RARS2 processed_transcript 1.2740397
DRIMSeq ENST00000582139 0.0236176 0.0045683 0.0001912 ENSG00000167281 RBFOX3 protein_coding 0.7743415
DRIMSeq ENST00000415831 0.0236176 0.0238805 0.0009993 ENSG00000167281 RBFOX3 protein_coding -0.6428233
DRIMSeq ENST00000270645 0.0168681 0.0000000 0.0002861 ENSG00000142552 RCN3 protein_coding -2.3697554
DRIMSeq ENST00000597801 0.0168681 0.0000000 0.0002861 ENSG00000142552 RCN3 protein_coding 2.3697554
DRIMSeq ENST00000381346 0.0414958 0.0000000 0.0014639 ENSG00000072042 RDH11 protein_coding 1.5702818
DRIMSeq ENST00000557331 0.0414958 0.0000000 0.0014639 ENSG00000072042 RDH11 nonsense_mediated_decay -1.5702818
DRIMSeq ENST00000317905 0.0016073 0.0034109 0.0000476 ENSG00000108469 RECQL5 protein_coding -1.3152913
DRIMSeq ENST00000579274 0.0016073 0.0052680 0.0000735 ENSG00000108469 RECQL5 processed_transcript 1.6897934
DRIMSeq ENST00000406246 0.0286343 0.0039963 0.0000836 ENSG00000173039 RELA protein_coding -1.0431225
DRIMSeq ENST00000392324 0.0066714 0.0002107 0.0000044 ENSG00000064490 RFXANK protein_coding -1.5535016
DRIMSeq ENST00000379359 0.0232151 0.0000000 0.0004904 ENSG00000102760 RGCC protein_coding -0.9493842
DRIMSeq ENST00000487837 0.0232151 0.0000000 0.0004904 ENSG00000102760 RGCC processed_transcript 0.9493842
DRIMSeq ENST00000332298 0.0386784 0.0145657 0.0006095 ENSG00000171700 RGS19 protein_coding -1.6558987
DRIMSeq ENST00000366285 0.0233756 0.0104892 0.0004389 ENSG00000171792 RHNO1 protein_coding 0.9650345
DRIMSeq ENST00000592247 0.0142257 0.0124079 0.0002596 ENSG00000131941 RHPN2 retained_intron -2.3739926
DRIMSeq ENST00000377885 0.0066714 0.0060482 0.0001265 ENSG00000137075 RNF38 protein_coding -0.9779660
DRIMSeq ENST00000259605 0.0066714 0.0319327 0.0006681 ENSG00000137075 RNF38 protein_coding 1.4323774
DRIMSeq ENST00000552502 0.0144000 0.0200157 0.0004188 ENSG00000257433 RP1-197B17.3 lincRNA -1.8039113
DRIMSeq ENST00000552133 0.0144000 0.0488663 0.0010225 ENSG00000257433 RP1-197B17.3 lincRNA 1.9876267
DRIMSeq ENST00000557551 0.0415266 0.0000000 0.0014807 ENSG00000258959 RP11-1017G21.4 antisense -1.0938003
DRIMSeq ENST00000557242 0.0415266 0.0000000 0.0014807 ENSG00000258959 RP11-1017G21.4 antisense 1.0938003
DRIMSeq ENST00000589510 0.0188026 0.0000000 0.0003461 ENSG00000267193 RP11-116O18.3 antisense 1.5891559
DRIMSeq ENST00000586213 0.0188026 0.0000000 0.0003461 ENSG00000267193 RP11-116O18.3 antisense -1.5891559
DRIMSeq ENST00000520237 0.0088046 0.0010875 0.0000228 ENSG00000174093 RP11-1407O15.2 protein_coding 0.9259373
DRIMSeq ENST00000564775 0.0228504 0.0000000 0.0004772 ENSG00000261840 RP11-146F11.1 antisense 1.4635917
DRIMSeq ENST00000568500 0.0228504 0.0000000 0.0004772 ENSG00000261840 RP11-146F11.1 antisense -1.4635917
DRIMSeq ENST00000560872 0.0460462 0.0095808 0.0001336 ENSG00000259234 RP11-17L5.4 lincRNA -0.9062493
DRIMSeq ENST00000305709 0.0291098 0.0000000 0.0007723 ENSG00000170161 RP11-262H14.4 lincRNA 2.9438677
DRIMSeq ENST00000467494 0.0291098 0.0000000 0.0007723 ENSG00000170161 RP11-262H14.4 lincRNA -2.9438677
DRIMSeq ENST00000517833 0.0140792 0.0017417 0.0000364 ENSG00000247317 RP11-273G15.2 lincRNA -0.8052428
DRIMSeq ENST00000303154 0.0337902 0.0054346 0.0001137 ENSG00000170089 RP11-423H2.1 transcribed_unprocessed_pseudogene -2.1101522
DRIMSeq ENST00000524167 0.0366161 0.0000000 0.0011147 ENSG00000253452 RP11-473J6.1 lincRNA 2.4356947
DRIMSeq ENST00000523748 0.0366161 0.0000000 0.0011147 ENSG00000253452 RP11-473J6.1 lincRNA -2.4356947
DRIMSeq ENST00000436905 0.0415266 0.0000000 0.0014824 ENSG00000237457 RP11-547I7.2 lincRNA 1.0051112
DRIMSeq ENST00000424735 0.0415266 0.0000000 0.0014824 ENSG00000237457 RP11-547I7.2 lincRNA -1.0051112
DRIMSeq ENST00000424308 0.0066668 0.0000000 0.0000498 ENSG00000230812 RP4-794H19.4 lincRNA 3.5843726
DRIMSeq ENST00000438195 0.0066668 0.0000000 0.0000498 ENSG00000230812 RP4-794H19.4 lincRNA -3.5843726
DRIMSeq ENST00000401447 0.0152497 0.0015232 0.0000212 ENSG00000106399 RPA3 protein_coding 2.0998392
DRIMSeq ENST00000391752 0.0168681 0.0039199 0.0001640 ENSG00000170889 RPS9 protein_coding 2.5631658
DRIMSeq ENST00000300738 0.0413406 0.0372409 0.0005195 ENSG00000167325 RRM1 protein_coding -1.0745055
DRIMSeq ENST00000429751 0.0114729 0.0005985 0.0000250 ENSG00000085721 RRN3 protein_coding 1.4966680
DRIMSeq ENST00000198767 0.0114729 0.0412806 0.0017275 ENSG00000085721 RRN3 protein_coding -0.8323631
DRIMSeq ENST00000323013 0.0399994 0.0207690 0.0008691 ENSG00000189306 RRP7A protein_coding -0.7115918
DRIMSeq ENST00000454950 0.0444097 0.0361915 0.0005048 ENSG00000204130 RUFY2 protein_coding -0.7072990
DRIMSeq ENST00000382298 0.0277868 0.0000000 0.0007028 ENSG00000151835 SACS protein_coding -1.2660676
DRIMSeq ENST00000476776 0.0277868 0.0000000 0.0007028 ENSG00000151835 SACS processed_transcript 1.2660676
DRIMSeq ENST00000270225 0.0196835 0.0018423 0.0000771 ENSG00000142230 SAE1 protein_coding -0.9956594
DRIMSeq ENST00000515816 0.0000270 0.0000062 0.0000001 ENSG00000167100 SAMD14 retained_intron 1.7959728
DRIMSeq ENST00000285206 0.0000270 0.0005107 0.0000107 ENSG00000167100 SAMD14 protein_coding -1.0788741
DRIMSeq ENST00000003834 0.0438669 0.0368209 0.0005136 ENSG00000004139 SARM1 retained_intron -0.9758894
DRIMSeq ENST00000229903 0.0350099 0.0071477 0.0002991 ENSG00000112167 SAYSD1 protein_coding 0.9540670
DRIMSeq ENST00000316097 0.0319243 0.0413737 0.0005771 ENSG00000227500 SCAMP4 protein_coding -0.7358693
DRIMSeq ENST00000397174 0.0008174 0.0000035 0.0000001 ENSG00000010803 SCMH1 protein_coding 3.0784708
DRIMSeq ENST00000357398 0.0456265 0.0108184 0.0004527 ENSG00000136531 SCN2A protein_coding 1.9057232
DRIMSeq ENST00000467651 0.0291518 0.0017500 0.0000244 ENSG00000162572 SCNN1D processed_transcript -3.5553000
DRIMSeq ENST00000264932 0.0178093 0.0019146 0.0000801 ENSG00000073578 SDHA protein_coding -1.0140144
DRIMSeq ENST00000505555 0.0178093 0.0304470 0.0012741 ENSG00000073578 SDHA retained_intron 1.1132052
DRIMSeq ENST00000399395 0.0488144 0.0110835 0.0004638 ENSG00000100445 SDR39U1 protein_coding -1.1251030
DRIMSeq ENST00000423034 0.0262051 0.0000000 0.0006345 ENSG00000184640 SEPT9 protein_coding 1.0114978
DRIMSeq ENST00000541152 0.0262051 0.0000000 0.0006345 ENSG00000184640 SEPT9 protein_coding -1.0114978
DRIMSeq ENST00000518437 0.0002232 0.0000003 0.0000000 ENSG00000206573 SETD5-AS1 antisense -1.5847008
DRIMSeq ENST00000400358 0.0064726 0.0004640 0.0000194 ENSG00000167037 SGSM1 protein_coding -0.9120369
DRIMSeq ENST00000470591 0.0064726 0.0012050 0.0000504 ENSG00000167037 SGSM1 processed_transcript 0.8896612
DRIMSeq ENST00000503071 0.0302169 0.0117517 0.0001229 ENSG00000169247 SH3TC2 processed_transcript 2.3312414
DRIMSeq ENST00000602239 0.0236176 0.0056567 0.0000592 ENSG00000160410 SHKBP1 retained_intron 2.5226967
DRIMSeq ENST00000378536 0.0018212 0.0000580 0.0000024 ENSG00000157933 SKI protein_coding -0.9287711
DRIMSeq ENST00000508416 0.0018212 0.0010707 0.0000448 ENSG00000157933 SKI processed_transcript 0.8883680
DRIMSeq ENST00000461616 0.0386784 0.0110564 0.0004627 ENSG00000221955 SLC12A8 processed_transcript -1.3056753
DRIMSeq ENST00000369626 0.0388082 0.0000000 0.0012464 ENSG00000155380 SLC16A1 protein_coding -1.0164828
DRIMSeq ENST00000478835 0.0388082 0.0000000 0.0012464 ENSG00000155380 SLC16A1 processed_transcript 1.0164828
DRIMSeq ENST00000345044 0.0140365 0.0035501 0.0000743 ENSG00000133460 SLC2A11 protein_coding -0.6717411
DRIMSeq ENST00000473157 0.0159637 0.0006532 0.0000091 ENSG00000125520 SLC2A4RG processed_transcript -2.2959060
DRIMSeq ENST00000371899 0.0030661 0.0001313 0.0000055 ENSG00000160326 SLC2A6 protein_coding -1.2282921
DRIMSeq ENST00000371897 0.0030661 0.0063975 0.0002677 ENSG00000160326 SLC2A6 protein_coding 1.1262030
DRIMSeq ENST00000343605 0.0470486 0.0000000 0.0018524 ENSG00000100036 SLC35E4 protein_coding -1.5092256
DRIMSeq ENST00000406566 0.0470486 0.0000000 0.0018524 ENSG00000100036 SLC35E4 protein_coding 1.5092256
DRIMSeq ENST00000495257 0.0392781 0.0000000 0.0012966 ENSG00000157800 SLC37A3 processed_transcript 0.8088996
DRIMSeq ENST00000326232 0.0392781 0.0000000 0.0012966 ENSG00000157800 SLC37A3 protein_coding -0.8088996
DRIMSeq ENST00000377369 0.0271797 0.0045191 0.0001891 ENSG00000148482 SLC39A12 protein_coding -0.9446863
DRIMSeq ENST00000377374 0.0271797 0.0200354 0.0008384 ENSG00000148482 SLC39A12 protein_coding 0.8230377
DRIMSeq ENST00000535347 0.0010311 0.0011647 0.0000244 ENSG00000111181 SLC6A12 protein_coding -1.5004534
DRIMSeq ENST00000280612 0.0010311 0.0000000 0.0000030 ENSG00000151012 SLC7A11 protein_coding -1.6516229
DRIMSeq ENST00000509248 0.0010311 0.0000000 0.0000030 ENSG00000151012 SLC7A11 nonsense_mediated_decay 1.6516229
DRIMSeq ENST00000555678 0.0026086 0.0015033 0.0000629 ENSG00000155465 SLC7A7 retained_intron 2.1411421
DRIMSeq ENST00000555702 0.0026086 0.0327648 0.0013711 ENSG00000155465 SLC7A7 protein_coding -1.7206978
DRIMSeq ENST00000452078 0.0388082 0.0000000 0.0012318 ENSG00000084453 SLCO1A2 protein_coding -0.8256880
DRIMSeq ENST00000463718 0.0388082 0.0000000 0.0012318 ENSG00000084453 SLCO1A2 retained_intron 0.8256880
DRIMSeq ENST00000506626 0.0019586 0.0002126 0.0000044 ENSG00000170365 SMAD1 processed_transcript 1.6353926
DRIMSeq ENST00000591914 0.0066714 0.0032406 0.0000452 ENSG00000141646 SMAD4 protein_coding -2.4271076
DRIMSeq ENST00000244520 0.0305452 0.0000000 0.0008506 ENSG00000124562 SNRPC protein_coding -1.8447219
DRIMSeq ENST00000374018 0.0305452 0.0000000 0.0008506 ENSG00000124562 SNRPC protein_coding 1.8447219
DRIMSeq ENST00000418788 0.0291518 0.0000000 0.0007829 ENSG00000224543 SNRPGP15 processed_pseudogene 2.8223554
DRIMSeq ENST00000600149 0.0291518 0.0000000 0.0007829 ENSG00000224543 SNRPGP15 processed_pseudogene -2.8223554
DRIMSeq ENST00000308342 0.0414099 0.0051414 0.0000717 ENSG00000172803 SNX32 protein_coding -0.9020106
DRIMSeq ENST00000308527 0.0089180 0.0000000 0.0000869 ENSG00000173548 SNX33 protein_coding 1.7959373
DRIMSeq ENST00000569152 0.0089180 0.0000000 0.0000869 ENSG00000173548 SNX33 protein_coding -1.7959373
DRIMSeq ENST00000206020 0.0471741 0.0000000 0.0018757 ENSG00000091640 SPAG7 protein_coding -0.7181095
DRIMSeq ENST00000571023 0.0471741 0.0000000 0.0018757 ENSG00000091640 SPAG7 processed_transcript 0.7181095
DRIMSeq ENST00000261866 0.0414958 0.0000000 0.0014701 ENSG00000104133 SPG11 protein_coding -0.7917938
DRIMSeq ENST00000560299 0.0414958 0.0000000 0.0014701 ENSG00000104133 SPG11 retained_intron 0.7917938
DRIMSeq ENST00000476377 0.0215993 0.0011817 0.0000247 ENSG00000133104 SPG20 processed_transcript 1.1341163
DRIMSeq ENST00000264659 0.0000042 0.0000138 0.0000003 ENSG00000017373 SRCIN1 protein_coding -0.8398709
DRIMSeq ENST00000581656 0.0000042 0.0001111 0.0000023 ENSG00000017373 SRCIN1 processed_transcript 0.9756534
DRIMSeq ENST00000586778 0.0343528 0.0078837 0.0001650 ENSG00000161547 SRSF2 retained_intron 1.2327994
DRIMSeq ENST00000557154 0.0000716 0.0000002 0.0000000 ENSG00000100650 SRSF5 protein_coding -2.0792415
DRIMSeq ENST00000348495 0.0287317 0.0474948 0.0019875 ENSG00000130511 SSBP4 protein_coding -1.2930314
DRIMSeq ENST00000437941 0.0370208 0.0117848 0.0004932 ENSG00000117155 SSX2IP protein_coding 1.0788515
DRIMSeq ENST00000361392 0.0013799 0.0000000 0.0000047 ENSG00000126091 ST3GAL3 protein_coding -2.1251239
DRIMSeq ENST00000361400 0.0013799 0.0000000 0.0000047 ENSG00000126091 ST3GAL3 protein_coding 2.1251239
DRIMSeq ENST00000444328 0.0366161 0.0293689 0.0012290 ENSG00000110080 ST3GAL4 protein_coding -1.0943350
DRIMSeq ENST00000393808 0.0236176 0.0018300 0.0000766 ENSG00000115525 ST3GAL5 protein_coding -0.9599002
DRIMSeq ENST00000492674 0.0005305 0.0000767 0.0000016 ENSG00000066923 STAG3 retained_intron 3.8836173
DRIMSeq ENST00000595181 0.0454731 0.0000000 0.0017095 ENSG00000076944 STXBP2 retained_intron 1.5092740
DRIMSeq ENST00000221283 0.0454731 0.0000000 0.0017095 ENSG00000076944 STXBP2 protein_coding -1.5092740
DRIMSeq ENST00000547586 0.0011638 0.0000155 0.0000002 ENSG00000139531 SUOX protein_coding 3.4056396
DRIMSeq ENST00000512997 0.0220696 0.0009303 0.0000195 ENSG00000204176 SYT15 protein_coding -1.3271994
DRIMSeq ENST00000276692 0.0032530 0.0002685 0.0000112 ENSG00000147687 TATDN1 protein_coding -1.4711635
DRIMSeq ENST00000520321 0.0032530 0.0242503 0.0010148 ENSG00000147687 TATDN1 nonsense_mediated_decay 1.7025512
DRIMSeq ENST00000258770 0.0066714 0.0003527 0.0000074 ENSG00000136270 TBRG4 protein_coding -1.6002542
DRIMSeq ENST00000325318 0.0014299 0.0025990 0.0000544 ENSG00000213123 TCTEX1D2 protein_coding -0.8966589
DRIMSeq ENST00000491186 0.0014299 0.0281887 0.0005898 ENSG00000213123 TCTEX1D2 processed_transcript 0.9343922
DRIMSeq ENST00000314250 0.0066668 0.0016963 0.0000355 ENSG00000111077 TENC1 protein_coding -0.7142071
DRIMSeq ENST00000552403 0.0066668 0.0277562 0.0005808 ENSG00000111077 TENC1 retained_intron 0.6986491
DRIMSeq ENST00000272438 0.0196835 0.0031051 0.0000650 ENSG00000144043 TEX261 protein_coding -1.0349599
DRIMSeq ENST00000374990 0.0187088 0.0020337 0.0000851 ENSG00000106799 TGFBR1 protein_coding 2.0244563
DRIMSeq ENST00000377627 0.0278433 0.0033315 0.0001394 ENSG00000041988 THAP3 protein_coding 1.7556276
DRIMSeq ENST00000368817 0.0187088 0.0000000 0.0003407 ENSG00000196407 THEM5 protein_coding -1.7436471
DRIMSeq ENST00000453881 0.0187088 0.0000000 0.0003407 ENSG00000196407 THEM5 protein_coding 1.7436471
DRIMSeq ENST00000354618 0.0463093 0.0130776 0.0002736 ENSG00000054118 THRAP3 protein_coding -0.6071240
DRIMSeq ENST00000452837 0.0256188 0.0096438 0.0001345 ENSG00000134077 THUMPD3 protein_coding -1.2211168
DRIMSeq ENST00000279263 0.0028413 0.0000073 0.0000001 ENSG00000149809 TM7SF2 protein_coding -1.7648473
DRIMSeq ENST00000258412 0.0454731 0.0000000 0.0017050 ENSG00000135926 TMBIM1 protein_coding -0.9466802
DRIMSeq ENST00000420341 0.0454731 0.0000000 0.0017050 ENSG00000135926 TMBIM1 protein_coding 0.9466802
DRIMSeq ENST00000481238 0.0415266 0.0128918 0.0005395 ENSG00000158604 TMED4 protein_coding 0.7377957
DRIMSeq ENST00000457408 0.0415266 0.0247698 0.0010365 ENSG00000158604 TMED4 protein_coding -0.6207155
DRIMSeq ENST00000549288 0.0021568 0.0001096 0.0000023 ENSG00000134291 TMEM106C protein_coding 3.0384602
DRIMSeq ENST00000382753 0.0098622 0.0007583 0.0000159 ENSG00000132406 TMEM128 protein_coding -1.1500210
DRIMSeq ENST00000382936 0.0132006 0.0082240 0.0001721 ENSG00000168936 TMEM129 protein_coding -0.7335287
DRIMSeq ENST00000480360 0.0132006 0.0430151 0.0009000 ENSG00000168936 TMEM129 nonsense_mediated_decay 1.0522273
DRIMSeq ENST00000537110 0.0228954 0.0047596 0.0001992 ENSG00000006118 TMEM132A processed_transcript 0.9809477
DRIMSeq ENST00000597370 0.0078481 0.0037711 0.0000395 ENSG00000161558 TMEM143 nonsense_mediated_decay 2.5173348
DRIMSeq ENST00000565468 0.0139758 0.0000000 0.0001929 ENSG00000261115 TMEM178B protein_coding -0.9101858
DRIMSeq ENST00000563442 0.0139758 0.0000000 0.0001929 ENSG00000261115 TMEM178B retained_intron 0.9101858
DRIMSeq ENST00000281017 0.0120253 0.0000000 0.0001544 ENSG00000151353 TMEM18 protein_coding 1.4723032
DRIMSeq ENST00000355654 0.0120253 0.0000000 0.0001544 ENSG00000151353 TMEM18 protein_coding -1.4723032
DRIMSeq ENST00000361906 0.0002232 0.0000023 0.0000000 ENSG00000198792 TMEM184B protein_coding -1.2219824
DRIMSeq ENST00000361684 0.0002232 0.0001137 0.0000024 ENSG00000198792 TMEM184B protein_coding 1.0403654
DRIMSeq ENST00000238788 0.0498511 0.0131848 0.0005517 ENSG00000119777 TMEM214 protein_coding -1.0458130
DRIMSeq ENST00000608611 0.0186052 0.0018722 0.0000783 ENSG00000186501 TMEM222 protein_coding -1.4103617
DRIMSeq ENST00000379299 0.0479198 0.0000000 0.0019386 ENSG00000089063 TMEM230 protein_coding 0.9318278
DRIMSeq ENST00000202834 0.0479198 0.0000000 0.0019386 ENSG00000089063 TMEM230 protein_coding -0.9318278
DRIMSeq ENST00000321196 0.0460462 0.0139210 0.0001942 ENSG00000179104 TMTC2 protein_coding -0.7965878
DRIMSeq ENST00000413971 0.0164430 0.0106157 0.0004442 ENSG00000077097 TOP2B nonsense_mediated_decay 1.2946108
DRIMSeq ENST00000272424 0.0077076 0.0010946 0.0000115 ENSG00000144034 TPRKB protein_coding -0.9399244
DRIMSeq ENST00000453386 0.0486374 0.0092188 0.0001929 ENSG00000136527 TRA2B protein_coding -0.8696028
DRIMSeq ENST00000558880 0.0151134 0.0042599 0.0000891 ENSG00000131323 TRAF3 retained_intron 0.8300841
DRIMSeq ENST00000412615 0.0079227 0.0002046 0.0000029 ENSG00000135148 TRAFD1 protein_coding -1.3175199
DRIMSeq ENST00000567312 0.0162533 0.0019006 0.0000265 ENSG00000167515 TRAPPC2L protein_coding -1.2429326
DRIMSeq ENST00000577426 0.0456265 0.0229534 0.0009605 ENSG00000153339 TRAPPC8 processed_transcript 0.6144598
DRIMSeq ENST00000441818 0.0263282 0.0026845 0.0000562 ENSG00000100416 TRMU nonsense_mediated_decay -0.8133667
DRIMSeq ENST00000485138 0.0008174 0.0000290 0.0000012 ENSG00000165125 TRPV6 retained_intron 1.7100676
DRIMSeq ENST00000463646 0.0008174 0.0001194 0.0000050 ENSG00000165125 TRPV6 retained_intron -1.2476065
DRIMSeq ENST00000463601 0.0061001 0.0001461 0.0000061 ENSG00000103197 TSC2 retained_intron 1.0686425
DRIMSeq ENST00000498097 0.0470082 0.0395465 0.0008275 ENSG00000135951 TSGA10 processed_transcript 0.7852308
DRIMSeq ENST00000373290 0.0013922 0.0000000 0.0000048 ENSG00000099282 TSPAN15 protein_coding -2.3248674
DRIMSeq ENST00000475069 0.0013922 0.0000000 0.0000048 ENSG00000099282 TSPAN15 retained_intron 2.3248674
DRIMSeq ENST00000508164 0.0098938 0.0004523 0.0000095 ENSG00000048140 TSPAN17 protein_coding -1.1291852
DRIMSeq ENST00000529221 0.0287317 0.0077394 0.0001619 ENSG00000149292 TTC12 protein_coding -1.7069887
DRIMSeq ENST00000472527 0.0319243 0.0031098 0.0000434 ENSG00000135912 TTLL4 retained_intron -1.2496065
DRIMSeq ENST00000258796 0.0011638 0.0000166 0.0000007 ENSG00000136295 TTYH3 protein_coding -1.1028939
DRIMSeq ENST00000400376 0.0011638 0.0011137 0.0000466 ENSG00000136295 TTYH3 protein_coding 1.0520785
DRIMSeq ENST00000248846 0.0383261 0.0047162 0.0000658 ENSG00000128159 TUBGCP6 protein_coding -0.9276863
DRIMSeq ENST00000503506 0.0000370 0.0000194 0.0000004 ENSG00000198431 TXNRD1 protein_coding -1.4125311
DRIMSeq ENST00000291552 0.0026182 0.0000219 0.0000002 ENSG00000160201 U2AF1 protein_coding -0.8800037
DRIMSeq ENST00000380276 0.0026182 0.0075896 0.0000794 ENSG00000160201 U2AF1 protein_coding 0.7824498
DRIMSeq ENST00000494576 0.0008174 0.0000553 0.0000012 ENSG00000134882 UBAC2 processed_transcript -1.4136709
DRIMSeq ENST00000460562 0.0008174 0.0145230 0.0003039 ENSG00000134882 UBAC2 processed_transcript 1.0985174
DRIMSeq ENST00000373910 0.0306250 0.0125094 0.0005235 ENSG00000072401 UBE2D1 protein_coding -0.8828690
DRIMSeq ENST00000345496 0.0162533 0.0004982 0.0000104 ENSG00000184787 UBE2G2 protein_coding -0.7187891
DRIMSeq ENST00000488418 0.0059902 0.0001874 0.0000026 ENSG00000160087 UBE2J2 protein_coding 1.3446713
DRIMSeq ENST00000360943 0.0286343 0.0029357 0.0000614 ENSG00000159202 UBE2Z protein_coding -0.7159087
DRIMSeq ENST00000354216 0.0042341 0.0007627 0.0000106 ENSG00000198276 UCKL1 protein_coding -1.0273157
DRIMSeq ENST00000509180 0.0026086 0.0244057 0.0005107 ENSG00000109775 UFSP2 protein_coding 1.2215603
DRIMSeq ENST00000335765 0.0091476 0.0001937 0.0000027 ENSG00000109103 UNC119 protein_coding -1.3518379
DRIMSeq ENST00000524574 0.0241927 0.0182382 0.0003816 ENSG00000134215 VAV3 processed_transcript 1.8195147
DRIMSeq ENST00000493786 0.0215033 0.0089651 0.0001876 ENSG00000112715 VEGFA retained_intron 1.1353827
DRIMSeq ENST00000283713 0.0120824 0.0078641 0.0001097 ENSG00000136059 VILL protein_coding 1.9796336
DRIMSeq ENST00000573314 0.0108017 0.0005497 0.0000077 ENSG00000138614 VWA9 nonsense_mediated_decay -1.6979060
DRIMSeq ENST00000261405 0.0479132 0.0000000 0.0019346 ENSG00000110799 VWF protein_coding 1.3836518
DRIMSeq ENST00000538635 0.0479132 0.0000000 0.0019346 ENSG00000110799 VWF processed_transcript -1.3836518
DRIMSeq ENST00000527986 0.0237692 0.0000000 0.0005301 ENSG00000254635 WAC-AS1 antisense -1.0432511
DRIMSeq ENST00000528337 0.0237692 0.0000000 0.0005301 ENSG00000254635 WAC-AS1 antisense 1.0432511
DRIMSeq ENST00000251289 0.0131100 0.0017262 0.0000361 ENSG00000065268 WDR18 protein_coding -0.9719241
DRIMSeq ENST00000395474 0.0066842 0.0000000 0.0000538 ENSG00000178252 WDR6 protein_coding 1.4013180
DRIMSeq ENST00000608424 0.0066842 0.0000000 0.0000538 ENSG00000178252 WDR6 protein_coding -1.4013180
DRIMSeq ENST00000375128 0.0026182 0.0000232 0.0000005 ENSG00000136936 XPA protein_coding -1.1472541
DRIMSeq ENST00000223273 0.0015758 0.0000196 0.0000008 ENSG00000241127 YAE1D1 protein_coding -1.0797949
DRIMSeq ENST00000469737 0.0015758 0.0161816 0.0006772 ENSG00000241127 YAE1D1 processed_transcript 0.9303155
DRIMSeq ENST00000376901 0.0281745 0.0050312 0.0001053 ENSG00000174851 YIF1A protein_coding -0.8383225
DRIMSeq ENST00000335953 0.0238427 0.0000000 0.0005367 ENSG00000109906 ZBTB16 protein_coding -0.8821190
DRIMSeq ENST00000545851 0.0238427 0.0000000 0.0005367 ENSG00000109906 ZBTB16 processed_transcript 0.8821190
DRIMSeq ENST00000262577 0.0438669 0.0000000 0.0016084 ENSG00000014164 ZC3H3 protein_coding -1.0340202
DRIMSeq ENST00000528401 0.0438669 0.0000000 0.0016084 ENSG00000014164 ZC3H3 protein_coding 1.0340202
DRIMSeq ENST00000370854 0.0000912 0.0000001 0.0000000 ENSG00000171307 ZDHHC16 protein_coding -2.1139856
DRIMSeq ENST00000299173 0.0105091 0.0088130 0.0001844 ENSG00000166140 ZFYVE19 protein_coding -0.9601799
DRIMSeq ENST00000357182 0.0289255 0.0037440 0.0001567 ENSG00000163867 ZMYM6 protein_coding -0.9407909
DRIMSeq ENST00000592529 0.0065328 0.0092090 0.0001285 ENSG00000167384 ZNF180 protein_coding -2.4128359
DRIMSeq ENST00000601993 0.0140365 0.0003465 0.0000073 ENSG00000160321 ZNF208 protein_coding 1.1290895
DRIMSeq ENST00000588312 0.0248575 0.0035570 0.0000744 ENSG00000090612 ZNF268 nonsense_mediated_decay 3.7756738
DRIMSeq ENST00000426813 0.0407671 0.0072000 0.0001004 ENSG00000168661 ZNF30 protein_coding -3.1193600
DRIMSeq ENST00000243643 0.0060303 0.0003722 0.0000078 ENSG00000170954 ZNF415 protein_coding -1.8529764
DRIMSeq ENST00000594012 0.0131100 0.0012025 0.0000503 ENSG00000198521 ZNF43 protein_coding -0.7952437
DRIMSeq ENST00000598288 0.0131100 0.0071325 0.0002985 ENSG00000198521 ZNF43 protein_coding 0.6377372
DRIMSeq ENST00000361807 0.0017975 0.0000000 0.0000070 ENSG00000198298 ZNF485 protein_coding -5.2613535
DRIMSeq ENST00000374435 0.0017975 0.0000000 0.0000070 ENSG00000198298 ZNF485 protein_coding 5.2613535
DRIMSeq ENST00000416136 0.0277868 0.0230956 0.0009665 ENSG00000249709 ZNF564 protein_coding 0.8884477
DRIMSeq ENST00000339282 0.0277868 0.0239762 0.0010033 ENSG00000249709 ZNF564 protein_coding -0.8055145
DRIMSeq ENST00000458270 0.0168681 0.0303595 0.0012705 ENSG00000183309 ZNF623 protein_coding 1.1627759
DRIMSeq ENST00000526926 0.0168681 0.0354094 0.0014818 ENSG00000183309 ZNF623 protein_coding -0.7313531
DRIMSeq ENST00000395219 0.0471741 0.0055435 0.0001160 ENSG00000229809 ZNF688 protein_coding -2.4200696
DRIMSeq ENST00000372507 0.0218151 0.0240719 0.0005037 ENSG00000164011 ZNF691 protein_coding 2.0047473
DRIMSeq ENST00000566625 0.0300421 0.0080767 0.0001690 ENSG00000179965 ZNF771 protein_coding 1.3272284
DRIMSeq ENST00000601857 0.0399994 0.0156517 0.0006550 ENSG00000213799 ZNF845 protein_coding 1.9246294
DEXSeq ENST00000464157 0.0147533 0.0007509 0.0000149 ENSG00000107331 ABCA2 processed_transcript 1.9741477
DEXSeq ENST00000420774 0.0276992 0.0068092 0.0000677 ENSG00000214870 AC004540.5 lincRNA 1.0622446
DEXSeq ENST00000417692 0.0280259 0.0036188 0.0000719 ENSG00000233230 AC079807.2 antisense 0.9072559
DEXSeq ENST00000497320 0.0438258 0.0097413 0.0001937 ENSG00000242474 AC093627.9 lincRNA -1.2075558
DEXSeq ENST00000217455 0.0319560 0.0000000 0.0000962 ENSG00000101473 ACOT8 protein_coding -1.0375808
DEXSeq ENST00000484975 0.0319560 0.0000000 0.0001476 ENSG00000101473 ACOT8 retained_intron 1.0380847
DEXSeq ENST00000373443 0.0311231 0.0133315 0.0000883 ENSG00000142920 ADC protein_coding -2.2437724
DEXSeq ENST00000407796 0.0454843 0.0000000 0.0002448 ENSG00000142208 AKT1 protein_coding -1.2131889
DEXSeq ENST00000555380 0.0454843 0.0000000 0.0003540 ENSG00000142208 AKT1 protein_coding 1.2138617
DEXSeq ENST00000344175 0.0462169 0.0390858 0.0002590 ENSG00000204673 AKT1S1 protein_coding -2.4560781
DEXSeq ENST00000358531 0.0161775 0.0020887 0.0000208 ENSG00000213390 ARHGAP19 protein_coding -1.5122782
DEXSeq ENST00000452522 0.0451945 0.0118982 0.0002365 ENSG00000074964 ARHGEF10L protein_coding -1.0469238
DEXSeq ENST00000536481 0.0427481 0.0185787 0.0001847 ENSG00000110237 ARHGEF17 retained_intron 0.8786830
DEXSeq ENST00000310256 0.0426548 0.0000000 0.0001832 ENSG00000173409 ARV1 protein_coding -0.8314768
DEXSeq ENST00000435927 0.0426548 0.0000000 0.0002814 ENSG00000173409 ARV1 protein_coding 0.8317807
DEXSeq ENST00000185907 0.0155398 0.0000000 0.0000161 ENSG00000204147 ASAH2B protein_coding 0.9648858
DEXSeq ENST00000374007 0.0155398 0.0000000 0.0000180 ENSG00000204147 ASAH2B protein_coding -0.9648062
DEXSeq ENST00000562396 0.0335650 0.0176287 0.0001168 ENSG00000166669 ATF7IP2 retained_intron 0.8761298
DEXSeq ENST00000359933 0.0322056 0.0103166 0.0001025 ENSG00000066739 ATG2B protein_coding -0.7748979
DEXSeq ENST00000257861 0.0383663 0.0238673 0.0001582 ENSG00000135407 AVIL protein_coding 0.7689175
DEXSeq ENST00000484002 0.0451139 0.0120450 0.0002394 ENSG00000121753 BAI2 processed_transcript 0.7017394
DEXSeq ENST00000369541 0.0451038 0.0000000 0.0002383 ENSG00000116752 BCAS2 protein_coding -0.9916882
DEXSeq ENST00000485021 0.0451038 0.0000000 0.0003410 ENSG00000116752 BCAS2 processed_transcript 0.9909855
DEXSeq ENST00000264381 0.0348028 0.0000000 0.0001263 ENSG00000114200 BCHE protein_coding -1.7751168
DEXSeq ENST00000540653 0.0348028 0.0000000 0.0002521 ENSG00000114200 BCHE protein_coding 1.7866598
DEXSeq ENST00000489183 0.0243025 0.0026552 0.0000528 ENSG00000119866 BCL11A processed_transcript 0.8457082
DEXSeq ENST00000409400 0.0458399 0.0392793 0.0002603 ENSG00000136717 BIN1 protein_coding -1.6101648
DEXSeq ENST00000533472 0.0487176 0.0148232 0.0002947 ENSG00000182993 C12orf60 processed_transcript 1.0527724
DEXSeq ENST00000397666 0.0320526 0.0043776 0.0000870 ENSG00000130731 C16orf13 protein_coding -0.8231392
DEXSeq ENST00000338401 0.0320526 0.0117331 0.0002332 ENSG00000130731 C16orf13 protein_coding 1.2854601
DEXSeq ENST00000565112 0.0133203 0.0005788 0.0000115 ENSG00000155330 C16orf87 protein_coding 1.1033509
DEXSeq ENST00000595077 0.0237181 0.0073322 0.0000486 ENSG00000006015 C19orf60 retained_intron 1.1632569
DEXSeq ENST00000294360 0.0449668 0.0319957 0.0002120 ENSG00000162384 C1orf123 protein_coding -1.0728009
DEXSeq ENST00000419612 0.0317633 0.0097016 0.0000964 ENSG00000197183 C20orf112 protein_coding 1.0859042
DEXSeq ENST00000359676 0.0317633 0.0203846 0.0002026 ENSG00000197183 C20orf112 protein_coding -0.5653623
DEXSeq ENST00000586876 0.0275420 0.0100533 0.0000666 ENSG00000167434 CA4 nonsense_mediated_decay 1.3687153
DEXSeq ENST00000277549 0.0000513 0.0000013 0.0000000 ENSG00000148408 CACNA1B protein_coding -0.9496141
DEXSeq ENST00000550804 0.0053229 0.0004956 0.0000033 ENSG00000012822 CALCOCO1 protein_coding -0.9834393
DEXSeq ENST00000237177 0.0429533 0.0188813 0.0001877 ENSG00000118412 CASP8AP2 processed_transcript -0.4755215
DEXSeq ENST00000588821 0.0172753 0.0025737 0.0000256 ENSG00000183401 CCDC159 retained_intron 3.1232820
DEXSeq ENST00000263102 0.0446211 0.0000000 0.0002170 ENSG00000108091 CCDC6 protein_coding -0.7380949
DEXSeq ENST00000518638 0.0446211 0.0000000 0.0003733 ENSG00000108091 CCDC6 retained_intron 0.7390301
DEXSeq ENST00000517487 0.0355748 0.0210700 0.0001396 ENSG00000175305 CCNE2 retained_intron 1.0277556
DEXSeq ENST00000310833 0.0455649 0.0117127 0.0002328 ENSG00000174059 CD34 protein_coding -0.8495901
DEXSeq ENST00000367041 0.0317647 0.0087554 0.0000870 ENSG00000117335 CD46 protein_coding -1.2859714
DEXSeq ENST00000476153 0.0451255 0.0215178 0.0002139 ENSG00000117266 CDK18 retained_intron 1.0863797
DEXSeq ENST00000514507 0.0263735 0.0030779 0.0000612 ENSG00000112877 CEP72 processed_transcript 1.1060809
DEXSeq ENST00000264935 0.0263735 0.0202279 0.0004021 ENSG00000112877 CEP72 protein_coding -0.7868682
DEXSeq ENST00000325167 0.0324662 0.0047566 0.0000946 ENSG00000176108 CHMP6 protein_coding -1.4373372
DEXSeq ENST00000572778 0.0324662 0.0294184 0.0005848 ENSG00000176108 CHMP6 protein_coding 1.1397841
DEXSeq ENST00000258930 0.0433468 0.0000000 0.0001980 ENSG00000136425 CIB2 protein_coding -1.5956416
DEXSeq ENST00000560618 0.0433468 0.0000000 0.0005258 ENSG00000136425 CIB2 protein_coding 1.6032493
DEXSeq ENST00000539413 0.0473317 0.0138134 0.0002746 ENSG00000122966 CIT processed_transcript 0.3665215
DEXSeq ENST00000488090 0.0348232 0.0126255 0.0001255 ENSG00000119946 CNNM1 processed_transcript 0.7862042
DEXSeq ENST00000462604 0.0004131 0.0000062 0.0000001 ENSG00000144810 COL8A1 processed_transcript 5.8725189
DEXSeq ENST00000267935 0.0136353 0.0024376 0.0000121 ENSG00000140365 COMMD4 protein_coding -1.2711630
DEXSeq ENST00000382395 0.0249714 0.0056425 0.0000561 ENSG00000137449 CPEB2 protein_coding -0.8510152
DEXSeq ENST00000550030 0.0344089 0.0185847 0.0001232 ENSG00000169372 CRADD processed_transcript 1.1836891
DEXSeq ENST00000332896 0.0344089 0.0477301 0.0003163 ENSG00000169372 CRADD protein_coding -1.1626318
DEXSeq ENST00000468839 0.0364583 0.0145767 0.0001449 ENSG00000007545 CRAMP1L retained_intron 1.0440394
DEXSeq ENST00000482691 0.0357863 0.0209287 0.0001387 ENSG00000163703 CRELD1 retained_intron 1.0035662
DEXSeq ENST00000513708 0.0486718 0.0147488 0.0002932 ENSG00000230561 CTC-228N24.1 lincRNA 0.9456918
DEXSeq ENST00000415461 0.0161189 0.0010606 0.0000211 ENSG00000085733 CTTN protein_coding 1.1305303
DEXSeq ENST00000577830 0.0451452 0.0223123 0.0002218 ENSG00000180891 CUEDC1 protein_coding -0.7587885
DEXSeq ENST00000490926 0.0141497 0.0007027 0.0000140 ENSG00000114395 CYB561D2 processed_transcript 1.4195431
DEXSeq ENST00000573984 0.0384621 0.0078801 0.0001567 ENSG00000167740 CYB5D2 protein_coding 0.8769765
DEXSeq ENST00000491083 0.0479358 0.0141088 0.0002805 ENSG00000146122 DAAM2 processed_transcript 0.9889428
DEXSeq ENST00000261891 0.0450867 0.0221714 0.0002204 ENSG00000035664 DAPK2 protein_coding -1.2278918
DEXSeq ENST00000446987 0.0453143 0.0337627 0.0002237 ENSG00000136271 DDX56 nonsense_mediated_decay -0.8393622
DEXSeq ENST00000220764 0.0282515 0.0036830 0.0000732 ENSG00000104325 DECR1 protein_coding -1.4658881
DEXSeq ENST00000521668 0.0282515 0.0071674 0.0001425 ENSG00000104325 DECR1 processed_transcript 1.3245404
DEXSeq ENST00000537639 0.0159772 0.0009124 0.0000181 ENSG00000146966 DENND2A protein_coding -5.1299661
DEXSeq ENST00000485359 0.0179888 0.0013846 0.0000275 ENSG00000198837 DENND4B retained_intron 1.0291223
DEXSeq ENST00000409775 0.0463127 0.0265714 0.0002641 ENSG00000105928 DFNA5 protein_coding -1.7725712
DEXSeq ENST00000332324 0.0458997 0.0127111 0.0002527 ENSG00000185000 DGAT1 protein_coding -0.7997587
DEXSeq ENST00000431497 0.0452008 0.0236873 0.0002354 ENSG00000231764 DLX6-AS1 antisense -0.9415012
DEXSeq ENST00000592152 0.0199632 0.0051304 0.0000340 ENSG00000187775 DNAH17 processed_transcript -1.9314506
DEXSeq ENST00000473051 0.0129596 0.0010297 0.0000102 ENSG00000148719 DNAJB12 retained_intron 0.9811873
DEXSeq ENST00000220496 0.0435310 0.0197841 0.0001966 ENSG00000104129 DNAJC17 protein_coding -0.8251132
DEXSeq ENST00000553645 0.0356380 0.0070801 0.0001407 ENSG00000119661 DNAL1 protein_coding -0.4892015
DEXSeq ENST00000555919 0.0356380 0.0329027 0.0006541 ENSG00000119661 DNAL1 protein_coding 0.6231266
DEXSeq ENST00000559585 0.0178800 0.0041954 0.0000278 ENSG00000134146 DPH6 processed_transcript -1.4653917
DEXSeq ENST00000394389 0.0450704 0.0108577 0.0002158 ENSG00000161326 DUSP14 protein_coding -1.0344867
DEXSeq ENST00000558813 0.0014534 0.0000180 0.0000004 ENSG00000128951 DUT protein_coding -0.8777551
DEXSeq ENST00000561350 0.0014534 0.0000224 0.0000004 ENSG00000128951 DUT processed_transcript 1.6189405
DEXSeq ENST00000342725 0.0043285 0.0002364 0.0000024 ENSG00000088881 EBF4 protein_coding -3.3065357
DEXSeq ENST00000521662 0.0423790 0.0182077 0.0001810 ENSG00000120533 ENY2 protein_coding -0.5334053
DEXSeq ENST00000460133 0.0160975 0.0018786 0.0000187 ENSG00000158220 ESYT3 processed_transcript -0.7557857
DEXSeq ENST00000468103 0.0160975 0.0054225 0.0000539 ENSG00000158220 ESYT3 retained_intron 0.9019386
DEXSeq ENST00000374280 0.0277868 0.0033464 0.0000665 ENSG00000158008 EXTL1 protein_coding -1.1324178
DEXSeq ENST00000470037 0.0277868 0.0216676 0.0004307 ENSG00000158008 EXTL1 processed_transcript 1.0337283
DEXSeq ENST00000588067 0.0161643 0.0010837 0.0000215 ENSG00000161682 FAM171A2 nonsense_mediated_decay 0.9247354
DEXSeq ENST00000293443 0.0161643 0.0428283 0.0008514 ENSG00000161682 FAM171A2 protein_coding -0.6997977
DEXSeq ENST00000494172 0.0335643 0.0055427 0.0001102 ENSG00000168754 FAM178B retained_intron 1.8965394
DEXSeq ENST00000520074 0.0335643 0.0129999 0.0002584 ENSG00000168754 FAM178B processed_transcript -1.2536785
DEXSeq ENST00000564424 0.0294168 0.0116143 0.0000770 ENSG00000172775 FAM192A protein_coding 1.1892810
DEXSeq ENST00000310542 0.0441600 0.0101996 0.0002028 ENSG00000173295 FAM86B3P processed_transcript -0.9547738
DEXSeq ENST00000252530 0.0333460 0.0177621 0.0001177 ENSG00000130244 FAM98C protein_coding -1.3485450
DEXSeq ENST00000467237 0.0498514 0.0318231 0.0003163 ENSG00000164896 FASTK retained_intron 0.9460292
DEXSeq ENST00000444207 0.0352425 0.0199542 0.0001322 ENSG00000100225 FBXO7 protein_coding 0.8202126
DEXSeq ENST00000586042 0.0316303 0.0043984 0.0000874 ENSG00000070388 FGF22 protein_coding -2.0481687
DEXSeq ENST00000602661 0.0334832 0.0112249 0.0001116 ENSG00000106692 FKTN protein_coding -1.0359112
DEXSeq ENST00000330753 0.0454147 0.0228969 0.0002276 ENSG00000185070 FLRT2 protein_coding -0.8054658
DEXSeq ENST00000570759 0.0014971 0.0000335 0.0000003 ENSG00000059122 FLYWCH1 processed_transcript 0.7968922
DEXSeq ENST00000478432 0.0453622 0.0351508 0.0002329 ENSG00000131781 FMO5 processed_transcript -0.7960449
DEXSeq ENST00000479318 0.0028476 0.0001803 0.0000012 ENSG00000149531 FRG1B nonsense_mediated_decay 1.1282478
DEXSeq ENST00000358464 0.0028476 0.0231283 0.0001533 ENSG00000149531 FRG1B protein_coding -0.8542483
DEXSeq ENST00000439954 0.0028476 0.0293734 0.0001946 ENSG00000149531 FRG1B protein_coding -0.7579418
DEXSeq ENST00000254108 0.0456188 0.0498530 0.0002478 ENSG00000089280 FUS protein_coding -0.7212387
DEXSeq ENST00000559095 0.0490621 0.0154766 0.0003077 ENSG00000156958 GALK2 processed_transcript 0.6609706
DEXSeq ENST00000473184 0.0353521 0.0204113 0.0001353 ENSG00000167491 GATAD2A processed_transcript 0.9279694
DEXSeq ENST00000377960 0.0495136 0.0153731 0.0003056 ENSG00000122694 GLIPR2 protein_coding -1.9226815
DEXSeq ENST00000246802 0.0384642 0.0000000 0.0001576 ENSG00000105373 GLTSCR2 protein_coding -0.5802323
DEXSeq ENST00000599253 0.0384642 0.0000000 0.0001904 ENSG00000105373 GLTSCR2 processed_transcript 0.5800481
DEXSeq ENST00000264039 0.0139983 0.0000000 0.0000131 ENSG00000063660 GPC1 protein_coding -0.6569467
DEXSeq ENST00000426280 0.0139983 0.0000000 0.0000145 ENSG00000063660 GPC1 protein_coding 0.6569540
DEXSeq ENST00000397088 0.0139404 0.0012807 0.0000127 ENSG00000164850 GPER1 protein_coding -1.3135895
DEXSeq ENST00000489654 0.0330692 0.0168755 0.0001118 ENSG00000197448 GSTK1 retained_intron 0.5678089
DEXSeq ENST00000448539 0.0313834 0.0088061 0.0000875 ENSG00000119041 GTF3C3 nonsense_mediated_decay 1.0713327
DEXSeq ENST00000484971 0.0098012 0.0006814 0.0000068 ENSG00000100226 GTPBP1 nonsense_mediated_decay 1.3730799
DEXSeq ENST00000506842 0.0022340 0.0000887 0.0000009 ENSG00000138642 HERC6 retained_intron 1.1783772
DEXSeq ENST00000376809 0.0000000 0.0000000 0.0000000 ENSG00000206503 HLA-A protein_coding 1.1780353
DEXSeq ENST00000376802 0.0000000 0.0000000 0.0000000 ENSG00000206503 HLA-A protein_coding -1.1781719
DEXSeq ENST00000450735 0.0453722 0.0346513 0.0002296 ENSG00000103942 HOMER2 protein_coding -0.6753980
DEXSeq ENST00000560374 0.0453722 0.0364129 0.0002413 ENSG00000103942 HOMER2 processed_transcript 0.5987107
DEXSeq ENST00000438032 0.0234422 0.0073342 0.0000486 ENSG00000127483 HP1BP3 protein_coding 0.8346948
DEXSeq ENST00000487117 0.0234422 0.0180726 0.0001198 ENSG00000127483 HP1BP3 processed_transcript 0.9082637
DEXSeq ENST00000358290 0.0008015 0.0000070 0.0000001 ENSG00000198189 HSD17B11 protein_coding -1.0658488
DEXSeq ENST00000508413 0.0008015 0.0000157 0.0000003 ENSG00000198189 HSD17B11 processed_transcript 2.1147787
DEXSeq ENST00000519735 0.0182641 0.0014512 0.0000288 ENSG00000104365 IKBKB protein_coding -0.8334304
DEXSeq ENST00000256108 0.0134361 0.0000000 0.0000113 ENSG00000133731 IMPA1 protein_coding -1.0413753
DEXSeq ENST00000522997 0.0134361 0.0000000 0.0000214 ENSG00000133731 IMPA1 protein_coding 1.0426950
DEXSeq ENST00000562918 0.0440552 0.0205696 0.0002045 ENSG00000140678 ITGAX processed_transcript 1.2090699
DEXSeq ENST00000366758 0.0441987 0.0104281 0.0002073 ENSG00000081692 JMJD4 protein_coding -1.8522198
DEXSeq ENST00000472869 0.0450975 0.0113124 0.0002249 ENSG00000135750 KCNK1 processed_transcript 1.1831023
DEXSeq ENST00000366621 0.0450975 0.0278237 0.0005531 ENSG00000135750 KCNK1 protein_coding -0.5723548
DEXSeq ENST00000479179 0.0202088 0.0032616 0.0000324 ENSG00000168301 KCTD6 protein_coding 0.6912096
DEXSeq ENST00000470573 0.0242224 0.0051124 0.0000508 ENSG00000117139 KDM5B processed_transcript 1.0050487
DEXSeq ENST00000327300 0.0320988 0.0000000 0.0000959 ENSG00000121774 KHDRBS1 protein_coding -0.8688409
DEXSeq ENST00000484270 0.0320988 0.0000000 0.0001197 ENSG00000121774 KHDRBS1 processed_transcript 0.8689331
DEXSeq ENST00000460881 0.0453839 0.0365206 0.0002420 ENSG00000149633 KIAA1755 retained_intron 0.7490998
DEXSeq ENST00000443149 0.0208149 0.0061245 0.0000406 ENSG00000183354 KIAA2026 processed_transcript 1.0242627
DEXSeq ENST00000436015 0.0208149 0.0067970 0.0000450 ENSG00000183354 KIAA2026 nonsense_mediated_decay 0.8340028
DEXSeq ENST00000534023 0.0485810 0.0296840 0.0002950 ENSG00000174996 KLC2 retained_intron 1.7323931
DEXSeq ENST00000347162 0.0352255 0.0000000 0.0001304 ENSG00000137171 KLC4 protein_coding -1.0111739
DEXSeq ENST00000463168 0.0352255 0.0000000 0.0001609 ENSG00000137171 KLC4 retained_intron 1.0115485
DEXSeq ENST00000497048 0.0452318 0.0112899 0.0002244 ENSG00000136826 KLF4 retained_intron 1.7661708
DEXSeq ENST00000392647 0.0239556 0.0000000 0.0000514 ENSG00000213160 KLHL23 protein_coding 1.2762743
DEXSeq ENST00000437875 0.0239556 0.0000000 0.0000892 ENSG00000213160 KLHL23 protein_coding -1.2798298
DEXSeq ENST00000304613 0.0466166 0.0000000 0.0002681 ENSG00000171798 KNDC1 protein_coding -0.7465795
DEXSeq ENST00000368571 0.0466166 0.0000000 0.0003490 ENSG00000171798 KNDC1 protein_coding 0.7463763
DEXSeq ENST00000418974 0.0262216 0.0060553 0.0000602 ENSG00000235398 LINC00623 lincRNA 1.9251008
DEXSeq ENST00000429464 0.0157759 0.0009401 0.0000187 ENSG00000235597 LINC01102 lincRNA 1.1466160
DEXSeq ENST00000478551 0.0336186 0.0055934 0.0001112 ENSG00000163818 LZTFL1 retained_intron 1.1061921
DEXSeq ENST00000292599 0.0277925 0.0069702 0.0000693 ENSG00000161021 MAML1 protein_coding -0.9090478
DEXSeq ENST00000507385 0.0277925 0.0194896 0.0001937 ENSG00000161021 MAML1 retained_intron 2.5778328
DEXSeq ENST00000330651 0.0281408 0.0000000 0.0000715 ENSG00000185386 MAPK11 protein_coding -0.7526864
DEXSeq ENST00000449719 0.0281408 0.0000000 0.0001592 ENSG00000185386 MAPK11 protein_coding 0.7496687
DEXSeq ENST00000358935 0.0029482 0.0000732 0.0000015 ENSG00000198060 MARCH5 protein_coding -0.7024309
DEXSeq ENST00000251472 0.0324437 0.0051159 0.0001017 ENSG00000105613 MAST1 protein_coding -0.7824267
DEXSeq ENST00000586884 0.0264680 0.0031218 0.0000621 ENSG00000141644 MBD1 retained_intron 0.6789477
DEXSeq ENST00000457839 0.0264680 0.0038012 0.0000756 ENSG00000141644 MBD1 protein_coding -0.8624020
DEXSeq ENST00000301327 0.0314482 0.0042169 0.0000838 ENSG00000167700 MFSD3 protein_coding -0.9590045
DEXSeq ENST00000591673 0.0463866 0.0130188 0.0002588 ENSG00000102858 MGRN1 processed_transcript 0.7631349
DEXSeq ENST00000309340 0.0446905 0.0217545 0.0002162 ENSG00000099875 MKNK2 protein_coding 1.4989768
DEXSeq ENST00000591601 0.0446905 0.0410381 0.0004079 ENSG00000099875 MKNK2 protein_coding -1.4612855
DEXSeq ENST00000566203 0.0202601 0.0017607 0.0000350 ENSG00000126005 MMP24-AS1 antisense 0.9306040
DEXSeq ENST00000258169 0.0437149 0.0000000 0.0001942 ENSG00000135698 MPHOSPH6 protein_coding -0.9663268
DEXSeq ENST00000569021 0.0437149 0.0000000 0.0002069 ENSG00000135698 MPHOSPH6 protein_coding 0.9663316
DEXSeq ENST00000367034 0.0477476 0.0000000 0.0002806 ENSG00000112110 MRPL18 protein_coding -0.7958483
DEXSeq ENST00000479638 0.0477476 0.0000000 0.0003559 ENSG00000112110 MRPL18 processed_transcript 0.7956226
DEXSeq ENST00000594784 0.0488168 0.0441963 0.0002929 ENSG00000141971 MVB12A protein_coding -4.0292650
DEXSeq ENST00000351429 0.0474423 0.0137867 0.0002741 ENSG00000156239 N6AMT1 protein_coding 1.1323961
DEXSeq ENST00000534548 0.0433072 0.0197899 0.0001967 ENSG00000151503 NCAPD3 protein_coding -0.9300633
DEXSeq ENST00000420993 0.0196601 0.0016353 0.0000325 ENSG00000025770 NCAPH2 protein_coding -0.8335836
DEXSeq ENST00000522048 0.0196601 0.0088839 0.0001766 ENSG00000025770 NCAPH2 retained_intron 0.5340252
DEXSeq ENST00000395698 0.0196601 0.0391744 0.0007788 ENSG00000025770 NCAPH2 protein_coding 0.8629591
DEXSeq ENST00000436750 0.0333409 0.0000000 0.0001144 ENSG00000154328 NEIL2 protein_coding -0.9867391
DEXSeq ENST00000284503 0.0333409 0.0000000 0.0001307 ENSG00000154328 NEIL2 protein_coding 0.9867589
DEXSeq ENST00000559571 0.0251406 0.0055559 0.0000552 ENSG00000140157 NIPA2 processed_transcript 1.0207247
DEXSeq ENST00000572559 0.0314928 0.0170480 0.0000847 ENSG00000153406 NMRAL1 processed_transcript 1.0505946
DEXSeq ENST00000404295 0.0314928 0.0462607 0.0002299 ENSG00000153406 NMRAL1 protein_coding -1.5998567
DEXSeq ENST00000464284 0.0330017 0.0056546 0.0001124 ENSG00000198929 NOS1AP protein_coding 0.5826599
DEXSeq ENST00000425241 0.0325846 0.0094669 0.0000941 ENSG00000177463 NR2C2 protein_coding -0.9041961
DEXSeq ENST00000352171 0.0455288 0.0000000 0.0002439 ENSG00000078618 NRD1 protein_coding -0.7837824
DEXSeq ENST00000464385 0.0455288 0.0000000 0.0002797 ENSG00000078618 NRD1 processed_transcript 0.7838598
DEXSeq ENST00000252594 0.0156008 0.0009878 0.0000196 ENSG00000130305 NSUN5 protein_coding 2.3993739
DEXSeq ENST00000438747 0.0156008 0.0029327 0.0000583 ENSG00000130305 NSUN5 protein_coding -1.7201404
DEXSeq ENST00000279206 0.0363936 0.0219619 0.0001455 ENSG00000149761 NUDT22 protein_coding -0.8085654
DEXSeq ENST00000550459 0.0464329 0.0000000 0.0002659 ENSG00000075188 NUP37 protein_coding 1.0369605
DEXSeq ENST00000552283 0.0464329 0.0000000 0.0003255 ENSG00000075188 NUP37 protein_coding -1.0374196
DEXSeq ENST00000379123 0.0435576 0.0195798 0.0001946 ENSG00000007372 PAX6 protein_coding 0.8657646
DEXSeq ENST00000440052 0.0422229 0.0089654 0.0001782 ENSG00000238197 PAXBP1-AS1 antisense 1.0411781
DEXSeq ENST00000498822 0.0495940 0.0314123 0.0003122 ENSG00000090097 PCBP4 retained_intron 1.0956257
DEXSeq ENST00000308824 0.0353701 0.0132631 0.0001318 ENSG00000203880 PCMTD2 protein_coding -0.7405277
DEXSeq ENST00000490749 0.0492048 0.0151549 0.0003013 ENSG00000186642 PDE2A retained_intron 0.8716561
DEXSeq ENST00000334456 0.0492048 0.0188396 0.0003745 ENSG00000186642 PDE2A protein_coding -0.6705194
DEXSeq ENST00000494559 0.0199293 0.0016330 0.0000325 ENSG00000121440 PDZRN3 protein_coding -0.5018944
DEXSeq ENST00000488858 0.0000000 0.0000000 0.0000000 ENSG00000162734 PEA15 processed_transcript 0.3807076
DEXSeq ENST00000360472 0.0000000 0.0000000 0.5342639 ENSG00000162734 PEA15 protein_coding 0.2550591
DEXSeq ENST00000472750 0.0494666 0.0462597 0.0003065 ENSG00000162735 PEX19 nonsense_mediated_decay 0.8011748
DEXSeq ENST00000413079 0.0014836 0.0000295 0.0000003 ENSG00000067057 PFKP protein_coding 1.5842582
DEXSeq ENST00000381072 0.0014836 0.0005299 0.0000053 ENSG00000067057 PFKP protein_coding 1.3274107
DEXSeq ENST00000381125 0.0014836 0.0010914 0.0000108 ENSG00000067057 PFKP protein_coding -1.3933861
DEXSeq ENST00000480008 0.0317302 0.0000000 0.0000979 ENSG00000130024 PHF10 retained_intron -0.6118879
DEXSeq ENST00000366780 0.0317302 0.0000000 0.0001148 ENSG00000130024 PHF10 protein_coding 0.6121189
DEXSeq ENST00000356976 0.0322408 0.0050438 0.0001003 ENSG00000100151 PICK1 protein_coding -0.8539558
DEXSeq ENST00000263967 0.0152479 0.0008140 0.0000162 ENSG00000121879 PIK3CA protein_coding -0.5358963
DEXSeq ENST00000465571 0.0313468 0.0044369 0.0000882 ENSG00000124181 PLCG1 processed_transcript 0.6278127
DEXSeq ENST00000326631 0.0164628 0.0022482 0.0000223 ENSG00000104886 PLEKHJ1 protein_coding -0.8360952
DEXSeq ENST00000282903 0.0229056 0.0046638 0.0000464 ENSG00000152952 PLOD2 protein_coding -1.4489120
DEXSeq ENST00000360060 0.0229056 0.0162240 0.0001613 ENSG00000152952 PLOD2 protein_coding 1.1973909
DEXSeq ENST00000483373 0.0460593 0.0260827 0.0002593 ENSG00000120756 PLS1 protein_coding 1.4641630
DEXSeq ENST00000354952 0.0194754 0.0016441 0.0000327 ENSG00000114698 PLSCR4 protein_coding -1.7585001
DEXSeq ENST00000593887 0.0201333 0.0056240 0.0000373 ENSG00000062822 POLD1 protein_coding 1.9595978
DEXSeq ENST00000312419 0.0199802 0.0054324 0.0000360 ENSG00000175482 POLD4 protein_coding -1.4902752
DEXSeq ENST00000503371 0.0349325 0.0192580 0.0001276 ENSG00000130997 POLN processed_transcript 0.7577688
DEXSeq ENST00000344697 0.0494364 0.0000000 0.0003125 ENSG00000144647 POMGNT2 protein_coding 1.0213761
DEXSeq ENST00000441964 0.0494364 0.0000000 0.0003264 ENSG00000144647 POMGNT2 protein_coding -1.0214010
DEXSeq ENST00000455780 0.0169233 0.0024372 0.0000242 ENSG00000127125 PPCS protein_coding -1.4520503
DEXSeq ENST00000301242 0.0462977 0.0000000 0.0002560 ENSG00000167641 PPP1R14A protein_coding -1.5910586
DEXSeq ENST00000587515 0.0462977 0.0000000 0.0003908 ENSG00000167641 PPP1R14A protein_coding 1.5893270
DEXSeq ENST00000590895 0.0175258 0.0025675 0.0000255 ENSG00000122490 PQLC1 processed_transcript 1.1736204
DEXSeq ENST00000375155 0.0478142 0.0141918 0.0002821 ENSG00000040487 PQLC2 protein_coding -0.9252251
DEXSeq ENST00000592741 0.0126947 0.0014184 0.0000094 ENSG00000130175 PRKCSH protein_coding -0.8235793
DEXSeq ENST00000548436 0.0343604 0.0122870 0.0001221 ENSG00000110844 PRPF40B retained_intron 0.8471639
DEXSeq ENST00000591949 0.0376767 0.0076724 0.0001525 ENSG00000205155 PSENEN protein_coding 1.2248354
DEXSeq ENST00000338910 0.0268600 0.0064028 0.0000636 ENSG00000121390 PSPC1 protein_coding -0.6958642
DEXSeq ENST00000492741 0.0268600 0.0468112 0.0004653 ENSG00000121390 PSPC1 nonsense_mediated_decay 0.5017319
DEXSeq ENST00000308020 0.0457097 0.0350795 0.0002325 ENSG00000174915 PTDSS2 protein_coding -0.8358544
DEXSeq ENST00000346049 0.0332889 0.0000000 0.0001117 ENSG00000120899 PTK2B protein_coding -1.2428583
DEXSeq ENST00000521000 0.0332889 0.0000000 0.0001274 ENSG00000120899 PTK2B retained_intron 1.2431292
DEXSeq ENST00000598632 0.0395959 0.0082600 0.0001642 ENSG00000104960 PTOV1 retained_intron 0.8287403
DEXSeq ENST00000599732 0.0395959 0.0209965 0.0004174 ENSG00000104960 PTOV1 protein_coding -1.0939320
DEXSeq ENST00000597793 0.0395959 0.0242355 0.0004818 ENSG00000104960 PTOV1 retained_intron 0.8343388
DEXSeq ENST00000555256 0.0435727 0.0196948 0.0001958 ENSG00000139998 RAB15 retained_intron 0.8054068
DEXSeq ENST00000297592 0.0357553 0.0140292 0.0001394 ENSG00000197275 RAD54B protein_coding -1.0629807
DEXSeq ENST00000296604 0.0199981 0.0018373 0.0000365 ENSG00000164188 RANBP3L protein_coding -0.6729579
DEXSeq ENST00000515759 0.0199981 0.0093508 0.0001859 ENSG00000164188 RANBP3L protein_coding 0.9884384
DEXSeq ENST00000430128 0.0442653 0.0102789 0.0002043 ENSG00000228016 RAPGEF4-AS1 antisense 2.0183340
DEXSeq ENST00000486790 0.0352640 0.0202291 0.0001340 ENSG00000180198 RCC1 protein_coding 2.3069718
DEXSeq ENST00000317905 0.0022132 0.0001154 0.0000008 ENSG00000108469 RECQL5 protein_coding -1.2920213
DEXSeq ENST00000392324 0.0023813 0.0000887 0.0000009 ENSG00000064490 RFXANK protein_coding -1.6020062
DEXSeq ENST00000366285 0.0239893 0.0025614 0.0000509 ENSG00000171792 RHNO1 protein_coding 0.9507221
DEXSeq ENST00000591292 0.0154944 0.0018851 0.0000187 ENSG00000067836 ROGDI retained_intron 1.0774540
DEXSeq ENST00000520237 0.0060789 0.0003924 0.0000039 ENSG00000174093 RP11-1407O15.2 protein_coding 0.9274266
DEXSeq ENST00000529127 0.0323076 0.0048136 0.0000957 ENSG00000254746 RP11-958J22.1 retained_intron 0.6497546
DEXSeq ENST00000401447 0.0044390 0.0003802 0.0000025 ENSG00000106399 RPA3 protein_coding 2.2442945
DEXSeq ENST00000506581 0.0000000 0.0000000 0.0000000 ENSG00000163682 RPL9 protein_coding -2.7999395
DEXSeq ENST00000295955 0.0000000 0.0000000 0.0000000 ENSG00000163682 RPL9 protein_coding 2.7997195
DEXSeq ENST00000300738 0.0295711 0.0117854 0.0000781 ENSG00000167325 RRM1 protein_coding -1.1121224
DEXSeq ENST00000454950 0.0028913 0.0001938 0.0000013 ENSG00000204130 RUFY2 protein_coding -0.7371014
DEXSeq ENST00000515816 0.0151888 0.0018857 0.0000187 ENSG00000167100 SAMD14 retained_intron 1.8680468
DEXSeq ENST00000285206 0.0151888 0.0079494 0.0000790 ENSG00000167100 SAMD14 protein_coding -1.0811342
DEXSeq ENST00000460767 0.0168103 0.0035687 0.0000236 ENSG00000227500 SCAMP4 processed_transcript 0.9720335
DEXSeq ENST00000397174 0.0420357 0.0179557 0.0001785 ENSG00000010803 SCMH1 protein_coding 3.1137296
DEXSeq ENST00000400358 0.0494487 0.0154758 0.0003076 ENSG00000167037 SGSM1 protein_coding -0.9642964
DEXSeq ENST00000470591 0.0494487 0.0281381 0.0005594 ENSG00000167037 SGSM1 processed_transcript 0.9012776
DEXSeq ENST00000558583 0.0278738 0.0000000 0.0000688 ENSG00000237515 SHISA9 protein_coding -0.7594214
DEXSeq ENST00000423335 0.0278738 0.0000000 0.0001307 ENSG00000237515 SHISA9 protein_coding 0.7580920
DEXSeq ENST00000378536 0.0123341 0.0004747 0.0000094 ENSG00000157933 SKI protein_coding -0.9396948
DEXSeq ENST00000508416 0.0123341 0.0220655 0.0004386 ENSG00000157933 SKI processed_transcript 0.9253961
DEXSeq ENST00000483348 0.0404366 0.0085358 0.0001697 ENSG00000163950 SLBP protein_coding -1.4227994
DEXSeq ENST00000535347 0.0429193 0.0189730 0.0001886 ENSG00000111181 SLC6A12 protein_coding -1.5441100
DEXSeq ENST00000280612 0.0228782 0.0000000 0.0000457 ENSG00000151012 SLC7A11 protein_coding -1.6838039
DEXSeq ENST00000509248 0.0228782 0.0000000 0.0000621 ENSG00000151012 SLC7A11 nonsense_mediated_decay 1.6834652
DEXSeq ENST00000555678 0.0000037 0.0000000 0.0000000 ENSG00000155465 SLC7A7 retained_intron 2.3905072
DEXSeq ENST00000506626 0.0011370 0.0000367 0.0000004 ENSG00000170365 SMAD1 processed_transcript 1.7191008
DEXSeq ENST00000221448 0.0035053 0.0003655 0.0000018 ENSG00000104852 SNRNP70 protein_coding -0.6158515
DEXSeq ENST00000308527 0.0335654 0.0000000 0.0001094 ENSG00000173548 SNX33 protein_coding 2.0169757
DEXSeq ENST00000569152 0.0335654 0.0000000 0.0002290 ENSG00000173548 SNX33 protein_coding -2.0347800
DEXSeq ENST00000585725 0.0488837 0.0440747 0.0002921 ENSG00000005206 SPPL2B processed_transcript 0.5945806
DEXSeq ENST00000581656 0.0030594 0.0001443 0.0000014 ENSG00000017373 SRCIN1 processed_transcript 1.0084271
DEXSeq ENST00000264659 0.0030594 0.0001804 0.0000018 ENSG00000017373 SRCIN1 protein_coding -0.8672747
DEXSeq ENST00000579954 0.0200768 0.0053839 0.0000357 ENSG00000141298 SSH2 protein_coding 0.8244015
DEXSeq ENST00000361392 0.0486388 0.0000000 0.0002894 ENSG00000126091 ST3GAL3 protein_coding -2.3079525
DEXSeq ENST00000361400 0.0486388 0.0000000 0.0003570 ENSG00000126091 ST3GAL3 protein_coding 2.3104406
DEXSeq ENST00000528605 0.0460386 0.0130927 0.0002603 ENSG00000110080 ST3GAL4 retained_intron 1.2554520
DEXSeq ENST00000461054 0.0323084 0.0102693 0.0001021 ENSG00000143093 STRIP1 processed_transcript 0.9756518
DEXSeq ENST00000369902 0.0492358 0.0152256 0.0003027 ENSG00000107882 SUFU protein_coding -0.8908526
DEXSeq ENST00000471000 0.0492358 0.0203802 0.0004051 ENSG00000107882 SUFU processed_transcript 1.0738196
DEXSeq ENST00000547586 0.0352934 0.0268192 0.0001333 ENSG00000139531 SUOX protein_coding 4.9233435
DEXSeq ENST00000532433 0.0452667 0.0344020 0.0002280 ENSG00000203705 TATDN3 retained_intron 1.0016411
DEXSeq ENST00000476978 0.0250586 0.0028622 0.0000569 ENSG00000204219 TCEA3 protein_coding 1.1565087
DEXSeq ENST00000491186 0.0458096 0.0249170 0.0002477 ENSG00000213123 TCTEX1D2 processed_transcript 1.0182622
DEXSeq ENST00000552403 0.0334403 0.0117918 0.0001172 ENSG00000111077 TENC1 retained_intron 0.7131749
DEXSeq ENST00000314250 0.0334403 0.0238267 0.0002368 ENSG00000111077 TENC1 protein_coding -0.7314882
DEXSeq ENST00000527851 0.0199044 0.0077100 0.0000383 ENSG00000149809 TM7SF2 retained_intron 1.3804889
DEXSeq ENST00000503148 0.0448667 0.0217288 0.0002160 ENSG00000198498 TMA16 retained_intron 1.3047104
DEXSeq ENST00000437139 0.0339230 0.0054755 0.0001088 ENSG00000179029 TMEM107 protein_coding -1.0936620
DEXSeq ENST00000480360 0.0452149 0.0216728 0.0002154 ENSG00000168936 TMEM129 nonsense_mediated_decay 1.0847372
DEXSeq ENST00000597370 0.0198987 0.0076090 0.0000378 ENSG00000161558 TMEM143 nonsense_mediated_decay 3.0577247
DEXSeq ENST00000565468 0.0459439 0.0000000 0.0002518 ENSG00000261115 TMEM178B protein_coding -0.9755069
DEXSeq ENST00000563442 0.0459439 0.0000000 0.0002819 ENSG00000261115 TMEM178B retained_intron 0.9756545
DEXSeq ENST00000361906 0.0338015 0.0109958 0.0001093 ENSG00000198792 TMEM184B protein_coding -1.3119099
DEXSeq ENST00000361684 0.0338015 0.0118871 0.0001182 ENSG00000198792 TMEM184B protein_coding 1.0682281
DEXSeq ENST00000598660 0.0394813 0.0165702 0.0001647 ENSG00000105696 TMEM59L retained_intron 0.8458150
DEXSeq ENST00000321196 0.0492546 0.0464287 0.0003077 ENSG00000179104 TMTC2 protein_coding -0.8001813
DEXSeq ENST00000375887 0.0281199 0.0071222 0.0000708 ENSG00000102524 TNFSF13B protein_coding -0.9180277
DEXSeq ENST00000441818 0.0362586 0.0146770 0.0001459 ENSG00000100416 TRMU nonsense_mediated_decay -0.8367554
DEXSeq ENST00000463646 0.0131232 0.0005376 0.0000107 ENSG00000165125 TRPV6 retained_intron -1.2879529
DEXSeq ENST00000485138 0.0131232 0.0012983 0.0000258 ENSG00000165125 TRPV6 retained_intron 1.7171188
DEXSeq ENST00000463601 0.0201771 0.0017785 0.0000354 ENSG00000103197 TSC2 retained_intron 1.1114886
DEXSeq ENST00000498097 0.0322999 0.0095446 0.0000949 ENSG00000135951 TSGA10 processed_transcript 0.7930141
DEXSeq ENST00000373290 0.0161307 0.0000000 0.0000175 ENSG00000099282 TSPAN15 protein_coding -2.6575264
DEXSeq ENST00000475069 0.0161307 0.0000000 0.0000272 ENSG00000099282 TSPAN15 retained_intron 2.6601275
DEXSeq ENST00000258796 0.0160997 0.0008994 0.0000179 ENSG00000136295 TTYH3 protein_coding -1.1483685
DEXSeq ENST00000400376 0.0160997 0.0022908 0.0000455 ENSG00000136295 TTYH3 protein_coding 1.0650193
DEXSeq ENST00000503506 0.0137322 0.0013298 0.0000132 ENSG00000198431 TXNRD1 protein_coding -1.6591122
DEXSeq ENST00000354940 0.0137322 0.0163981 0.0001630 ENSG00000198431 TXNRD1 protein_coding 1.0612903
DEXSeq ENST00000460562 0.0046301 0.0002759 0.0000027 ENSG00000134882 UBAC2 processed_transcript 1.0422158
DEXSeq ENST00000494576 0.0046301 0.0258230 0.0002567 ENSG00000134882 UBAC2 processed_transcript -1.5950497
DEXSeq ENST00000345496 0.0491443 0.0301504 0.0002997 ENSG00000184787 UBE2G2 protein_coding -0.7539220
DEXSeq ENST00000397514 0.0355049 0.0000000 0.0001367 ENSG00000103275 UBE2I protein_coding -0.5250603
DEXSeq ENST00000406620 0.0355049 0.0000000 0.0002082 ENSG00000103275 UBE2I protein_coding 0.5253241
DEXSeq ENST00000488418 0.0089759 0.0009026 0.0000060 ENSG00000160087 UBE2J2 protein_coding 1.3163608
DEXSeq ENST00000369908 0.0441286 0.0310703 0.0002059 ENSG00000198276 UCKL1 protein_coding 0.8754907
DEXSeq ENST00000279907 0.0450306 0.0119109 0.0002368 ENSG00000111647 UHRF1BP1L protein_coding -0.5430137
DEXSeq ENST00000484980 0.0318335 0.0147031 0.0000974 ENSG00000109103 UNC119 protein_coding 0.8847405
DEXSeq ENST00000283713 0.0452593 0.0354084 0.0002346 ENSG00000136059 VILL protein_coding 2.1991012
DEXSeq ENST00000573314 0.0249875 0.0083762 0.0000555 ENSG00000138614 VWA9 nonsense_mediated_decay -1.8103804
DEXSeq ENST00000375128 0.0215763 0.0042860 0.0000426 ENSG00000136936 XPA protein_coding -1.1807830
DEXSeq ENST00000223273 0.0012262 0.0000183 0.0000004 ENSG00000241127 YAE1D1 protein_coding -1.1181848
DEXSeq ENST00000469737 0.0012262 0.0117934 0.0002344 ENSG00000241127 YAE1D1 processed_transcript 0.9670990
DEXSeq ENST00000474392 0.0012262 0.0240464 0.0004780 ENSG00000241127 YAE1D1 retained_intron 0.9716046
DEXSeq ENST00000335953 0.0181612 0.0000000 0.0000273 ENSG00000109906 ZBTB16 protein_coding -0.8864832
DEXSeq ENST00000545851 0.0181612 0.0000000 0.0000342 ENSG00000109906 ZBTB16 processed_transcript 0.8865920
DEXSeq ENST00000370854 0.0337987 0.0176255 0.0001168 ENSG00000171307 ZDHHC16 protein_coding -2.3737700
DEXSeq ENST00000533216 0.0163053 0.0011336 0.0000225 ENSG00000162300 ZFPL1 retained_intron 1.3161995
DEXSeq ENST00000357182 0.0456652 0.0125326 0.0002491 ENSG00000163867 ZMYM6 protein_coding -1.0265644
DEXSeq ENST00000259395 0.0199776 0.0018850 0.0000375 ENSG00000136870 ZNF189 protein_coding 0.7442631
DEXSeq ENST00000594012 0.0013311 0.0000182 0.0000004 ENSG00000198521 ZNF43 protein_coding -0.8022288
DEXSeq ENST00000598288 0.0013311 0.0003298 0.0000066 ENSG00000198521 ZNF43 protein_coding 0.6428067
DEXSeq ENST00000361807 0.0309112 0.0000000 0.0000885 ENSG00000198298 ZNF485 protein_coding -4.1677474
DEXSeq ENST00000374435 0.0309112 0.0000000 0.0002572 ENSG00000198298 ZNF485 protein_coding 4.1527983
DEXSeq ENST00000458270 0.0430037 0.0093983 0.0001868 ENSG00000183309 ZNF623 protein_coding 1.1258107
DEXSeq ENST00000601935 0.0454195 0.0471526 0.0002343 ENSG00000197372 ZNF675 protein_coding 0.5916161
DEXSeq ENST00000566625 0.0098260 0.0007075 0.0000070 ENSG00000179965 ZNF771 protein_coding 1.3342531
DEXSeq ENST00000563508 0.0352521 0.0065219 0.0001297 ENSG00000140265 ZSCAN29 processed_transcript -0.7129352
DEXSeq ENST00000561661 0.0352521 0.0381311 0.0007580 ENSG00000140265 ZSCAN29 protein_coding 0.4546207